Molecular investigation of the Pfmdr1 gene of Plasmodium falciparum isolates in Henan Province imported from Africa

Parasitology ◽  
2018 ◽  
Vol 146 (3) ◽  
pp. 372-379 ◽  
Author(s):  
Chengyun Yang ◽  
Ruimin Zhou ◽  
Ying Liu ◽  
Suhua Li ◽  
Dan Qian ◽  
...  
Keyword(s):  
South Africa ◽  
West Africa ◽  
East Africa ◽  
North Africa ◽  
Migrant Workers ◽  
Central Africa ◽  
Henan Province ◽  
Pfmdr1 Gene ◽  
Antimalarial Resistance ◽  
African Migrant

AbstractEfficacious antimalarial drugs are important for malaria control and elimination, and continuous monitoring of their efficacy is essential. The prevalence and distribution of Pfmdr1 were evaluated in African migrant workers in Henan Province. Among 632 isolates, 13 haplotypes were identified, NYSND (39.87%, 252/632), YYSND (2.85%, 18/632), NFSND (31.01%, 196/632), NYSNY (0.47%, 3/632), YFSND (13.77%, 87/632), NFSNY (0.32%, 2/632), YYSNY (2.06%, 13/632), YFSNY (0.16%, 1/632), N/Y YSND (1.90%, 12/632), N Y/F SND (6.17%, 39/632), N/Y Y/F SND (0.47%, 3/632), YYSN D/Y (0.16%, 1/632) and N/Y FSND (0.79%, 5/632). The highest frequency of NYSND was observed in individuals from North Africa (63.64%, 7/11), followed by South Africa (61.33%, 111/181), Central Africa (33.33%, 56/168), West Africa (28.94%, 68/235) and East Africa (27.03%, 10/37) (χ2 = 54.605, P < 0.05). The highest frequency of NFSND was observed in East Africa (48.65%, 18/37), followed by West Africa (39.14%, 92/235), Central Africa (26.79%, 45/168), South Africa (22.65%, 41/181) and North Africa (9.09%, 1/11) (χ2 = 22.368 P < 0.05). The mutant prevalence of codons 86 and 184 decreased. These data may provide complementary information on antimalarial resistance that may be utilized in the development of a treatment regimen for Henan Province.

Introduction

2018 ◽  
Author(s):  
Marina Sharpe
Keyword(s):  
West Africa ◽  
Great Lakes ◽  
East Africa ◽  
North Africa ◽  
Southern Africa ◽  
Theoretical Approach ◽  
Central Africa ◽  
Horn Of Africa ◽  
Refugee Protection

This introductory chapter begins by presenting the book’s structure in section A. Section B then delineates the book’s contours, outlining four aspects of refugee protection in Africa that are not addressed. Section C provides context, with a contemporary overview of the state of refugee protection in Africa. It also looks at the major aspects of the refugee situations in each of Africa’s principal geographic sub-regions: East Africa (including the Horn of Africa), Central Africa and the Great Lakes, West Africa, Southern Africa, and North Africa. Section D then concludes with an outline of the theoretical approach to regime relationships employed throughout the book.

scholarly journals Regional African stock markets indices

2002 ◽  
Vol 33 (1) ◽  
pp. 11-19
Author(s):  
T. Fish ◽  
N. Biekpe
Keyword(s):  
West Africa ◽  
East Africa ◽  
North Africa ◽  
Stock Markets ◽  
African Continent ◽  
The Subject ◽  
Market Trends ◽  
Market Capitalisation

This paper presents an overview of the construction of regional indices for three of the four regions within Africa. The three indices are the EASDEX (for East Africa), the NADEX (for North Africa) and the WADEX (for West Africa). The SADC region has been excluded, as it has recently been concluded as the subject of study, in which the index, the SADIX was constructed (Tyandela, 2001). The weekly market capitalisation data collected for the construction of these indices was further used to construct an All-Africa index. These indices could in future assist investors both locally and internationally to determine the movement of indices as a way of assessing market trends and opportunities for investment on the African continent.

The early history of West African highlife music

Popular Music ◽  
1989 ◽  
Vol 8 (3) ◽  
pp. 221-230 ◽  
Author(s):  
John Collins
Keyword(s):  
South Africa ◽  
North Africa ◽  
Central Africa ◽  
West African ◽  
Early History ◽  
Dance Music ◽  
East African ◽  
East African Coast ◽  
African Coast ◽  
History Of

Highlife is one of the myriad varieties of acculturated popular dance-music styles that have been emerging from Africa this century and which fuse African with Western (i.e. European and American) and islamic influences. Besides highlife, other examples include kwela, township jive and mbaqanga from South Africa, chimurenga from Zimbabwe, the benga beat from Kenya, taraab music from the East African coast, Congo jazz (soukous) from Central Africa, rai music from North Africa, juju and apala music from western Nigeria, makossa from the Cameroons and mbalax from Senegal.

scholarly journals Polish Jews in Africa in the interwar period

2016 ◽  
Vol 6 (1) ◽  
pp. 65-73
Author(s):  
Jacek Knopek
Keyword(s):  
South Africa ◽  
East Africa ◽  
Jewish Community ◽  
Interwar Period ◽  
North Africa ◽  
Important Place ◽  
Political Activities ◽  
Polish Jews ◽  
Hired Labor ◽  
The Individual

Abstract The article presents the emigration of Polish Jewish community to the individual regions in Africa in the years 1918-1939. It is stated in it that Africa was not really popular among Polish immigrants. Before 1939 only about 4200 people who had Polish citizenship lived on this large continent. Polish Jews occupied an important place among the population. Relatively the largest colonies of Polish Jews were then in North Africa (Egypt and the Maghreb) and in South Africa. Smaller ones were created in West, Central and East Africa. The wealthiest group of Polish Jews lived in Egypt and South Africa, where they were engaged in trade. In other regions, that group dealt with craft, had small shops or livied on hired labor. Polish Jews were involved in the development of Polish and of Polish origin association life in Africa. They contributed also to establishing business contacts between Poland and African lands. Individuals received satisfactory material status and a good professional position or were engaged in political activities.

scholarly journals The Life-history of the Native Mine Labourer in the Transvaal

1906 ◽  
Vol 6 (2) ◽  
pp. 149-174 ◽  
Author(s):  
L. G. Irvine ◽  
D. Macaulay
Keyword(s):  
South Africa ◽  
Life History ◽  
West Africa ◽  
East Coast ◽  
Central Africa ◽  
Gold Mines ◽  
Mining Areas ◽  
South West ◽  
History Of ◽  
South West Africa

In the month of June, 1905, no fewer than 99,518 natives were employed on mines and works in the labour districts of the Witwatersrand, and the neighbouring mining areas of Klerksdorp, Heidelberg, and Vereeniging. In addition to these there were also working on the gold mines over 45,000 Chinese labourers. This vast industrial army is recruited from many and in great measure from very distant sources. Of the natives employed during the year ending June, 1905, the whole of British South Africa furnished only just over 32%: less than 2% came from British Central Africa: 60% were drawn from the Southern Portuguese East Coast provinces; and 3.6% from the Portuguese provinces north of latitude 22°. German South-West Africa contributed under 1%, but this area has latterly ceased to be a source of supply.

scholarly journals Why are East African Players Absent in European Football? Localizing African Football Migration Along Structural Constraints, Colonial Legacies and Voluntary Immobility

2020 ◽  
Vol 44 (5) ◽  
pp. 397-420 ◽  
Author(s):  
Christian Ungruhe ◽  
Mads Backer Schmidt
Keyword(s):  
West Africa ◽  
East Africa ◽  
North Africa ◽  
Structural Constraints ◽  
African Continent ◽  
East African ◽  
Massive Influx ◽  
Colonial Legacies ◽  
European Football ◽  
Scholarly Attention

While studies on transnational African football migration have increasingly attracted scholarly attention, little is known about the continent’s regional particularities. However, in contrast to the massive influx of footballers from West and North Africa, squads of European professional clubs seldom include players from East Africa. Yet, the concentration on West Africa in academic studies runs the risk of overgeneralizing certain practices on the African continent and, hence, of reproducing Africa’s standing as the homogeneous peripheral other. By analyzing the various historical, structural, and socio-cultural reasons for the general absence of migrant footballers from East Africa, we aim at contributing to a more nuanced picture of African football migration and further discuss the ambivalent consequences of players’ spatial immobility for East Africa’s football development.

Vernacular Text-Books in South African Native Schools

Africa ◽  
1935 ◽  
Vol 8 (2) ◽  
pp. 183-209 ◽  
Author(s):  
Clement M. Doke
Keyword(s):  
South Africa ◽  
West Africa ◽  
East Africa ◽  
South African ◽  
Literary Language ◽  
South West ◽  
Northern Sotho ◽  
South West Africa ◽  
Opening Paragraph

Opening ParagraphIn this survey of vernacular text-books I am confining my attention to the Union of South Africa and the three High Commission Territories of Basutoland, Bechuanaland, and Swaziland. In this area we have five important literary language forms in use, viz. Xhosa and Zulu (belonging to the Nguni cluster of Bantu), and Southern Sotho, Tšwana, and Northern Sotho (belonging to the Sotho cluster). Reference will be made to two other languages spoken in the northern and eastern Transvaal, Venda and Tonga (commonly written as Thonga, and belonging to the cluster of languages spoken in Portuguese East Africa from Delagoa Bay northwards). I do not intend to deal with the languages spoken in the Mandated Territory of South-west Africa, nor with such intrusions as that of Kalanga into the Bechuanaland Protectorate.

scholarly journals Phylogenetic and Evolutionary Relationships among Yellow Fever Virus Isolates in Africa

2001 ◽  
Vol 75 (15) ◽  
pp. 6999-7008 ◽  
Author(s):  
John-Paul Mutebi ◽  
Heiman Wang ◽  
Li Li ◽  
Juliet E. Bryant ◽  
Alan D. T. Barrett
Keyword(s):  
Amino Acid ◽  
West Africa ◽  
East Africa ◽  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Amino Acid Level ◽  
Central Africa ◽  
The Other ◽  
Genotype I ◽  
East Central

ABSTRACT Previous studies with a limited number of strains have indicated that there are two genotypes of yellow fever (YF) virus in Africa, one in west Africa and the other in east and central Africa. We have examined the prM/M and a portion of the E protein for a panel of 38 wild strains of YF virus from Africa representing different countries and times of isolation. Examination of the strains revealed a more complex genetic relationship than previously reported. Overall, nucleotide substitutions varied from 0 to 25.8% and amino acid substitutions varied from 0 to 9.1%. Phylogenetic analysis using parsimony and neighbor-joining algorithms identified five distinct genotypes: central/east Africa, east Africa, Angola, west Africa I, and west Africa II. Extensive variation within genotypes was observed. Members of west African genotype II and central/east African genotype differed by 2.8% or less, while west Africa genotype I varied up to 6.8% at the nucleotide level. We speculate that the former two genotypes exist in enzootic transmission cycles, while the latter is genetically more heterogeneous due to regular human epidemics. The nucleotide sequence of the Angola genotype diverged from the others by 15.7 to 23.0% but only 0.4 to 5.6% at the amino acid level, suggesting that this genotype most likely diverged from a progenitor YF virus in east/central Africa many years ago, prior to the separation of the other east/central African strains analyzed in this study, and has evolved independently. These data demonstrate that there are multiple genotypes of YF virus in Africa and suggest independent evolution of YF virus in different areas of Africa.

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