Teenage motherhood and risk of premature death: long-term follow-up in the ONS Longitudinal Study

2011 ◽  
Vol 41 (9) ◽  
pp. 1867-1877 ◽  
Author(s):  
R. T. Webb ◽  
C. E. Marshall ◽  
K. M. Abel

BackgroundTeenage motherhood is relatively common in the UK, but little is known about related health inequalities in this population. We estimated cause-specific mortality risks over three decades in a nationally representative cohort.MethodWe examined premature mortality in a 1.1% sample of all women who were teenagers in England and Wales during the 1970s, 1980s and 1990s using data from the Office for National Statistics Longitudinal Study (ONS LS). Our primary outcome was suicide. Long-term follow-up to 31 December 2006, to a potential maximum age of 49 years, was achieved through near-complete routine linkage to national mortality records. We created a time-dependent exposure variable, with relative risks estimated according to age when women first experienced motherhood versus a reference group of those currently without children.ResultsWomen who were teenage mothers were around 30% more likely to die prematurely by any cause and almost 60% more likely to die unnaturally, whereas first-time motherhood at mature age conferred lower risk compared to women without children. Teenage motherhood was associated with a more than doubled risk of suicide [mortality rate ratio (MRR) 2.23, 95% confidence interval (CI) 1.30–3.83], and elevated risks of fatal cancer of the cervix and lung were also found. Changing the reference category to first-time mothers at 20 years and above also revealed a significant elevation in risk of accidental death.ConclusionsThe complex psychosocial needs of these women require greater attention from clinicians, public health professionals, social services and policymakers. Their elevated risk of poor health outcomes may persist well beyond the actual teenage motherhood years.

2014 ◽  
Vol 7 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Luigi C. Clauser ◽  
Giuseppe Consorti ◽  
Giovanni Elia ◽  
Manlio Galié ◽  
Riccardo Tieghi

The use of adipose tissue transfer for correction of maxillofacial defects was reported for the first time at the end of the 19th century. Structural fat grafting (SFG) was introduced as a way to improve facial esthetics and in recent years has evolved into applications in craniomaxillofacial reconstructive surgery. Several techniques have been proposed for harvesting and grafting the fat. However, owing to the damage of many adipocytes during these maneuvers, the results have not been satisfactory and have required several fat injection procedures for small corrections. The author's (L.C.) overview the application of SFG in the management of volumetric deficit in the craniomaxillofacial in patients treated with a long-term follow-up.


Author(s):  
Marie Noëlle Falewee ◽  
Christophe Hebert ◽  
Karen Benezery ◽  
Alexandre Bozec ◽  
Joël Guigay ◽  
...  

<p class="abstract"><strong>Background:</strong> Dysphagia is a serious sequel of head and neck cancer (HNC) and its treatment. This dysfunction is frequent and likely underreported by clinical exam. It seems necessary to assess its global burden during the pre, per and post treatment periods (up to 18 months), regardless of the treatment received.</p><p class="abstract"><strong>Methods:</strong> This was a prospective cohort study assessing the rate of dysphagia in first-time treated HNC patients, using the deglutition handicap index questionnaire (DHI) and the clinician reporting. Time to occurrence, severity and length of the dysfunction were recorded. The benefit of an evaluation by the patient himself was investigated.  </p><p class="abstract"><strong>Results:</strong> Of 134 evaluable patients: 22 were treated by surgery alone (16.4%), 16 by radiotherapy (RT) alone (11.9%), 3 by chemotherapy (CT) alone (2.2%), 28 by RTCT (20.9%), 31 by induction chemotherapy followed by RTCT (23.1%), 11 by surgery+RT (8.2%) and 23 by surgery+RTCT (17.2%). Patients completed 87.9% of the expected DHI. The dysphagia frequency reported was 92.2% by patient-reporting and 80.9% by clinicians-reporting, whatever the intensity. Self-perceived moderate to severe dysphagia was reported in 69.8% of patients.</p><p class="abstract"><strong>Conclusions:</strong> Given the strong impact of dysphagia on the quality of life and prognosis of HNC patients, it appears essential to perform screening and systematic monitoring. Using a simple and well accepted questionnaire, such as DHI, which is also well correlated with clinical evaluation, we demonstrated a significant frequency of dysphagia. The use of real-time patient-reported outcomes for its early detection would be an asset, particularly during long-term follow-up.</p><p class="abstract">Registered under ClinicalTrials.gov Identifier no. NCT03068559.</p>


2007 ◽  
Vol 65 (3b) ◽  
pp. 758-763 ◽  
Author(s):  
Daniel Benzecry Almeida ◽  
Paola Hesse Poletto ◽  
Jerônimo Buzetti Milano ◽  
André Giacomelli Leal ◽  
Ricardo Ramina

Lumbar disc herniation (LDH) is a common cause of back and sciatic pain. When clinical treatment fails, surgery may be indicated in selected patients. Although surgery is effective in most cases, some of these patients may have a poor outcome. Different factors may influence these results and poor adaptation at work is one well-known cause of treatment failure. This study examines 350 patients on long-term follow-up after surgery for first-time LDH. The relationship was analyzed between occupation before surgery and outcome (maintenance of lumbar and leg pain, satisfaction with the surgical treatment and return to work). The preoperative occupation (employed in public or private services, autonomous, unemployed, housewife, retired or student) and the exertion at work were analyzed as prognostic factors for different clinical outcomes. Although unemployed people had higher numerical analog scale for lumbar pain and retired patients had a higher leg pain, this difference was not statistically significant. Retired people were significantly less satisfied with the surgical result. Higher exertion at work showed a statistically insignificant higher level of pain and lower degree of satisfaction. The authors conclude that preoperative occupation was not a statistically significant factor in this series of patients.


1980 ◽  
Vol 136 (2) ◽  
pp. 181-190 ◽  
Author(s):  
Gavin Tennent ◽  
Elizabeth Parker ◽  
Patrick G. McGrath ◽  
David Street

SummaryThe social, criminal and psychiatric backgrounds of 878 male patients admitted for the first time to the three English Special Hospitals during the years 1961–1965 are examined and the implications of differences between them for research discussed. It is noted that only 35 per cent of the admission group have been discharged within a four year period. The need for long term follow-up studies is stressed.


Genes ◽  
2020 ◽  
Vol 11 (11) ◽  
pp. 1356
Author(s):  
Jee Myung Yang ◽  
Beom Hee Lee ◽  
Gi-Byoung Nam ◽  
June-Gone Kim ◽  
Joo Yong Lee

Background: Peripheral pigmentary changes are common amongst women with Danon disease; however, there is currently a lack of longitudinal observational studies of the retinal changes in this condition, and the long-term visual prognosis is not well understood. Methods and Results: In this report, we present long-term follow-up data (12 years of follow-up) regarding peripheral retinopathy in an Asian woman and her mother who were both diagnosed with Danon disease. Both patients showed a novel nonsense mutation of the LAMP2 gene (c.123 of exon 2). During the follow-up period, no evident extension of peripheral pigmented lesions or visual field progression was observed. Conclusions: We report, for the first time, the long-term longitudinal follow-up of Danon disease-related retinopathy in an Asian patient featuring an indolent macular-sparing peripheral lesion.


2016 ◽  
Vol 5 (1) ◽  
pp. 24-30 ◽  
Author(s):  
Harriet M. Gunn ◽  
Hanna Emilsson ◽  
Melissa Gabriel ◽  
Ann M. Maguire ◽  
Katharine S. Steinbeck

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