Identifying groups of airborne particles by ordination

Author(s):  
M. Shlepr ◽  
C. M. Vicroy

The microelectronics industry is heavily tasked with minimizing contaminates at all steps of the manufacturing process. Particles are generated by physical and/or chemical fragmentation from a mothersource. The tools and macrovolumes of chemicals used for processing, the environment surrounding the process, and the circuits themselves are all potential particle sources. A first step in eliminating these contaminants is to identify their source. Elemental analysis of the particles often proves useful toward this goal, and energy dispersive spectroscopy (EDS) is a commonly used technique. However, the large variety of source materials and process induced changes in the particles often make it difficult to discern if the particles are from a common source.Ordination is commonly used in ecology to understand community relationships. This technique usespair-wise measures of similarity. Separation of the data set is based on discrimination functions. Theend product is a spatial representation of the data with the distance between points equaling the degree of dissimilarity.

Machines ◽  
2018 ◽  
Vol 6 (4) ◽  
pp. 63 ◽  
Author(s):  
Xavier Escaler ◽  
Toufik Mebarki

A sample of healthy wind turbines from the same wind farm with identical sizes and designs was investigated to determine the average vibrational signatures of the drive train components during normal operation. The units were variable-speed machines with three blades. The rotor was supported by two bearings, and the drive train connected to an intermediate three-stage planetary/helical gearbox. The nominal 2 MW output power was regulated using blade pitch adjustment. Vibrations were measured in exactly the same positions using the same type of sensors over a six-month period covering the entire range of operating conditions. The data set was preliminary validated to remove outliers based on the theoretical power curves. The most relevant frequency peaks in the rotor, gearbox, and generator vibrations were detected and identified based on averaged power spectra. The amplitudes of the peaks induced by a common source of excitation were compared in different measurement positions. A wind speed dependency of broadband vibration amplitudes was also observed. Finally, a fault detection case is presented showing the change of vibration signature induced by a damage in the gearbox.


1999 ◽  
Vol 589 ◽  
Author(s):  
Deborah L. Boxall ◽  
Edward A. Kenik ◽  
Charles M. Lukehart

AbstractThermolysis of single-source molecular precursors has been used to prepare carbon-supported Pt1Sn1, Pt1Ru1, and Pt3Mo1 alloy nanoparticles. On-particle, high spatial resolution energy dispersive spectroscopy (HR-EDS) has been used to determine the extent of compositional variability between particles in the nanocomposite. The loss of volatile Ru and Mo oxides during the course of the HR-EDS analysis results in average compositions greatly enriched in Pt. Mathematical correction for loss of these volatile species results in average metal:metal ratios comparable to those measured by bulk elemental analysis.


Author(s):  
Ivan Lugovoi ◽  
Dimitrios A. Andritsos ◽  
Claire Senot

Problem definition: Process innovation is commonly claimed to be a major source of competitive advantage for firms. Despite this perceived influence, it has received substantially less attention than product innovation, and much uncertainty remains about its true association with firm performance. We investigate the relationship between a pharmaceutical firm’s portfolio of manufacturing process innovations and its economic performance. Academic/practical relevance: We uniquely conduct a multidimensional evaluation of a firm’s portfolio of manufacturing process innovations at the product level. This allows a quantitative evaluation of both the relative benefit of the different dimensions of a portfolio as well as the potential complementarities between these in different technological landscapes. Methodology: Through a collaboration with expert patent attorneys, we develop a unique longitudinal data set that combines secondary data and evaluations of a firm’s portfolio of process patents along two key dimensions: novelty and scope. We conduct econometric analyses for a large-scale sample of active pharmaceutical ingredients (APIs) whose product patents have expired and for which process innovation is thus the main source of competitive advantage. Results: We find a positive association between the presence of manufacturing process innovation and firm performance. However, although portfolio’s scope appears to always be beneficial to performance, the effect of novelty alone depends on the ruggedness of the technological landscape: negative in smoother landscapes and positive in more rugged landscapes. Results further suggest that novelty and scope of a portfolio of process innovations are complementary across technological landscapes. Managerial implications: Our results provide important practical insights that can inform the organization and execution of the research and development process across high-technology industries. In particular, although process innovations can be economically beneficial, investing in high-novelty process innovations without a corresponding high scope could jeopardize payoffs, especially in technological landscapes that are relatively smooth.


Author(s):  
Stefan Steger ◽  
Alexander Brenning ◽  
Rainer Bell ◽  
Thomas Glade

Abstract. There is unanimous agreement that a precise spatial representation of past landslide occurrences is a prerequisite to produce high quality statistical landslide susceptibility models. Even though perfectly accurate landslide inventories rarely exist, investigations of how landslide inventory-based errors propagate into subsequent statistical landslide susceptibility models are scarce. The main objective of this research was to systematically examine whether and how inventory-based positional inaccuracies of different magnitudes influence modelled relationships, validation results, variable importance and the visual appearance of landslide susceptibility maps. The study was conducted for a landslide-prone site located in the districts of Amstetten and Waidhofen/Ybbs, Eastern Austria, where an earth-slide point inventory (n = 591) was available. The methodological approach comprised an artificial introduction of inventory-based positional errors into the present landslide data set and an in-depth evaluation of subsequent modelling results. Positional errors were introduced by artificially changing the original landslide position by a mean distance of 5, 10, 20, 50 and 120 m. The resulting differently precise response variables were separately used to train logistic regression models. Odds ratios of predictor variables provided insights into modelled relationships. Cross-validation and spatial cross-validation enabled an assessment of predictive performances and permutation-based variable importance. All analyses were additionally carried out with synthetically generated data sets to further verify the findings under rather controlled conditions. The results revealed that an increasing positional inventory-based error was generally related to increasing distortions of modelling and validation results. However, the findings also highlighted that interdependencies between inventory-based spatial inaccuracies and statistical landslide susceptibility models are complex. The systematic comparisons of 12 models provided valuable evidence that the respective error-propagation was not only determined by the degree of positional inaccuracy inherent in the landslide data, but also by the spatial representation of landslides and the environment, landslide magnitude, the characteristics of the study area, the selected classification method and an interplay of predictors within multiple variable models. Based on the results, we deduced that a direct propagation of minor to moderate inventory-based positional errors into modelling results can be partly counteracted by adapting the modelling design (e.g. generalization of input data, opting for strongly generalizing classifiers). Since positional errors within landslide inventories are common and subsequent modelling and validation results are likely to be distorted, the potential existence of inventory-based positional inaccuracies should always be considered when assessing landslide susceptibility by means of empirical models.


2018 ◽  
Vol 75 (2) ◽  
pp. 151-159 ◽  
Author(s):  
Ali Ebrahim ◽  
Martin V. Appleby ◽  
Danny Axford ◽  
John Beale ◽  
Tadeo Moreno-Chicano ◽  
...  

The ability to determine high-quality, artefact-free structures is a challenge in micro-crystallography, and the rapid onset of radiation damage and requirement for a high-brilliance X-ray beam mean that a multi-crystal approach is essential. However, the combination of crystal-to-crystal variation and X-ray-induced changes can make the formation of a final complete data set challenging; this is particularly true in the case of metalloproteins, where X-ray-induced changes occur rapidly and at the active site. An approach is described that allows the resolution, separation and structure determination of crystal polymorphs, and the tracking of radiation damage in microcrystals. Within the microcrystal population of copper nitrite reductase, two polymorphs with different unit-cell sizes were successfully separated to determine two independent structures, and an X-ray-driven change between these polymorphs was followed. This was achieved through the determination of multiple serial structures from microcrystals using a high-throughput high-speed fixed-target approach coupled with robust data processing.


2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Stephan Klähn ◽  
Stefan Mikkat ◽  
Matthias Riediger ◽  
Jens Georg ◽  
Wolfgang R. Hess ◽  
...  

AbstractMicroorganisms evolved specific acclimation strategies to thrive in environments of high or fluctuating salinities. Here, salt acclimation in the model cyanobacterium Synechocystis sp. PCC 6803 was analyzed by integrating transcriptomic, proteomic and metabolomic data. A dynamic reorganization of the transcriptome occurred during the first hours after salt shock, e.g. involving the upregulation of genes to activate compatible solute biochemistry balancing osmotic pressure. The massive accumulation of glucosylglycerol then had a measurable impact on the overall carbon and nitrogen metabolism. In addition, we observed the coordinated induction of putative regulatory RNAs and of several proteins known for their involvement in other stress responses. Overall, salt-induced changes in the proteome and transcriptome showed good correlations, especially among the stably up-regulated proteins and their transcripts. We define an extended salt stimulon comprising proteins directly or indirectly related to compatible solute metabolism, ion and water movements, and a distinct set of regulatory RNAs involved in post-transcriptional regulation. Our comprehensive data set provides the basis for engineering cyanobacterial salt tolerance and to further understand its regulation.


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