Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery

2020 ◽  
Author(s):  
Gina Porras ◽  
François Chassagne ◽  
James T. Lyles ◽  
Lewis Marquez ◽  
Micah Dettweiler ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Plant Natural Products ◽  
Antibiotic Drug

scholarly journals The role of Rho GTPases’ substrates Rac and Cdc42 in osteoclastogenesis and relevant natural medicinal products study

2020 ◽  
Vol 40 (7) ◽  
Author(s):  
Yuan Liu ◽  
Yusheng Dou ◽  
Liang Yan ◽  
Xiaobin Yang ◽  
Baorong He ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Bone Loss ◽  
Rho Gtpases ◽  
Medicinal Products ◽  
Cellular Functions ◽  
Recent Advancement ◽  
And Function ◽  
Cytoskeleton Rearrangements

Abstract Recently, Rho GTPases substrates include Rac (Rac1 and Rac2) and Cdc42 that have been reported to exert multiple cellular functions in osteoclasts, the most prominent of which includes regulating the dynamic actin cytoskeleton rearrangements. In addition, natural products and their molecular frameworks have a long tradition as valuable starting points for medicinal chemistry and drug discovery. Although currently, there are reports about the natural product, which could play a therapeutic role in bone loss diseases (osteoporosis and osteolysis) through the regulation of Rac1/2 and Cdc42 during osteoclasts cytoskeletal structuring. There have been several excellent studies for exploring the therapeutic potentials of various natural products for their role in inhibiting cancer cells migration and function via regulating the Rac1/2 and Cdc42. Herein in this review, we try to focus on recent advancement studies for extensively understanding the role of Rho GTPases substrates Rac1, Rac2 and Cdc42 in osteoclastogenesis, as well as therapeutic potentials of natural medicinal products for their properties on the regulation of Rac1, and/or Rac2 and Cdc42, which is in order to inspire drug discovery in regulating osteoclastogenesis.

The Role of Natural Products in Drug Discovery

2015 ◽  
pp. 379-429 ◽  
Author(s):  
Lars Ole Haustedt ◽  
Karsten Siems
Keyword(s):  
Natural Products ◽  
Drug Discovery
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