Plant Natural Products in Anti-Diabetic Drug Discovery

2010 ◽  
Vol 14 (16) ◽  
pp. 1670-1677 ◽  
Author(s):  
Alan L. Harvey
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Plant Natural Products

Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery

2020 ◽  
Author(s):  
Gina Porras ◽  
François Chassagne ◽  
James T. Lyles ◽  
Lewis Marquez ◽  
Micah Dettweiler ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Plant Natural Products ◽  
Antibiotic Drug

scholarly journals Metabolomics in the Context of Plant Natural Products Research: From Sample Preparation to Metabolite Analysis

Metabolites ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 37 ◽  
Author(s):  
Mohamed A. Salem ◽  
Leonardo Perez de Souza ◽  
Ahmed Serag ◽  
Alisdair R. Fernie ◽  
Mohamed A. Farag ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Sample Preparation ◽  
Plant Sample ◽  
Lead Compounds ◽  
Natural Extracts ◽  
Plant Natural Products ◽  
Single Compound ◽  
Indispensable Tool ◽  
Complex Chemistry

Plant-derived natural products have long been considered a valuable source of lead compounds for drug development. Natural extracts are usually composed of hundreds to thousands of metabolites, whereby the bioactivity of natural extracts can be represented by synergism between several metabolites. However, isolating every single compound from a natural extract is not always possible due to the complex chemistry and presence of most secondary metabolites at very low levels. Metabolomics has emerged in recent years as an indispensable tool for the analysis of thousands of metabolites from crude natural extracts, leading to a paradigm shift in natural products drug research. Analytical methods such as mass spectrometry (MS) and nuclear magnetic resonance (NMR) are used to comprehensively annotate the constituents of plant natural products for screening, drug discovery as well as for quality control purposes such as those required for phytomedicine. In this review, the current advancements in plant sample preparation, sample measurements, and data analysis are presented alongside a few case studies of the successful applications of these processes in plant natural product drug discovery.

Plant Natural Products in Anticancer Drug Discovery

2010 ◽  
Vol 14 (16) ◽  
pp. 1781-1791 ◽  
Author(s):  
Paul G. Grothaus ◽  
Gordon M. Cragg ◽  
David J. Newman
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Anticancer Drug ◽  
Plant Natural Products ◽  
Anticancer Drug Discovery

scholarly journals Automated High-Throughput System to Fractionate Plant Natural Products for Drug Discovery

2010 ◽  
Vol 73 (4) ◽  
pp. 751-754 ◽  
Author(s):  
Ying Tu ◽  
Cynthia Jeffries ◽  
Hong Ruan ◽  
Cynthia Nelson ◽  
David Smithson ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
High Throughput ◽  
Plant Natural Products
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