scholarly journals Integrin-Mediated Targeted Cancer Therapy Using c(RGDyK)-Based Conjugates of Gemcitabine

2021 ◽  
Author(s):  
Theodora Chatzisideri ◽  
George Leonidis ◽  
Theodoros Karampelas ◽  
Eleni Skavatsou ◽  
Angeliki Velentza-Almpani ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Cancer Therapy

Targeted Cancer Therapy; Nanotechnology Approaches for Overcoming Drug Resistance

2015 ◽  
Vol 22 (11) ◽  
pp. 1335-1347 ◽  
Author(s):  
Yan Gao ◽  
Jacson Shen ◽  
Lara Milane ◽  
Francis Hornicek ◽  
Mansoor Amiji ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Cancer Therapy ◽  
Targeted Cancer Therapy

Biological Carrier Molecules of Radiopharmaceuticals for Molecular Cancer Imaging and Targeted Cancer Therapy

2014 ◽  
Vol 20 (32) ◽  
pp. 5218-5244 ◽  
Author(s):  
A. Aerts ◽  
N.R.E.N. Impens ◽  
M. Gijs ◽  
M. D'Huyvetter ◽  
H. Vanmarcke ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cancer Imaging ◽  
Targeted Cancer Therapy

TEM8 Targeted Cancer Therapy

2011 ◽  
Vol 11 (10) ◽  
pp. 983-992 ◽  
Author(s):  
Arthur E. Frankel ◽  
Carol Carter ◽  
Shu-Ru Kuo ◽  
Jung-Hee Woo ◽  
Jeremy Mauldin ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Cancer Therapy

Novel Nanotechnology Approaches for Targeted Cancer Therapy

2014 ◽  
Vol 3 (2) ◽  
pp. 83-88 ◽  
Author(s):  
Maria Gazouli ◽  
Nikolitsa Nomikou ◽  
John F Callan ◽  
Efstathios P. Efstathopoulos
Keyword(s):  
Cancer Therapy ◽  
Targeted Cancer Therapy

Comparative radium-223 labeling with NOTA and DOTA-somatostatin derivatives for a potential use in targeted cancer therapy

2019 ◽  
Vol 72-73 ◽  
pp. S50-S51
Author(s):  
M. Riondato ◽  
S. Pastorino ◽  
V. Duce ◽  
E. Giovannini ◽  
A. Ciarmiello
Keyword(s):  
Cancer Therapy ◽  
Targeted Cancer Therapy ◽  
Radium 223 ◽  
Potential Use

Multicolor Two‐photon Nanosystem for Multiplexed Intracellular Imaging and Targeted Cancer Therapy

2021 ◽  
Author(s):  
Yong-Xiang Wu ◽  
Dailiang Zhang ◽  
Xiaoxiao Hu ◽  
Ruizi Peng ◽  
Junbin Li ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Cancer Therapy ◽  
Intracellular Imaging ◽  
Two Photon

scholarly journals Immune Cell Membrane‐Coated Biomimetic Nanoparticles for Targeted Cancer Therapy

Small ◽  
2021 ◽  
pp. 2006484
Author(s):  
Fatemeh Oroojalian ◽  
Mohammad Beygi ◽  
Behzad Baradaran ◽  
Ahad Mokhtarzadeh ◽  
Mohammad‐Ali Shahbazi
Keyword(s):  
Cancer Therapy ◽  
Cell Membrane ◽  
Immune Cell ◽  
Targeted Cancer Therapy ◽  
Biomimetic Nanoparticles

Novel N-Methylated Cyclodepsipeptide Prodrugs for Targeted Cancer Therapy

2021 ◽  
Vol 64 (2) ◽  
pp. 991-1000
Author(s):  
Chunlei Wu ◽  
Zhehong Cheng ◽  
Danyi Lu ◽  
Ke Liu ◽  
Yulian Cheng ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Cancer Therapy

scholarly journals DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Ruixue Huang ◽  
Ping-Kun Zhou
Keyword(s):  
Dna Damage ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
Dna Damage Response ◽  
Dna Damage Repair ◽  
Therapeutic Effects ◽  
Targeted Cancer Therapy ◽  
Baseline Drift ◽  
Damage Repair ◽  
Damage Response

AbstractGenomic instability is the hallmark of various cancers with the increasing accumulation of DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is typically based on this property of cancers. However, the adverse effects including normal tissues injury are also accompanied by the radiotherapy and chemotherapy. Targeted cancer therapy has the potential to suppress cancer cells’ DNA damage response through tailoring therapy to cancer patients lacking specific DNA damage response functions. Obviously, understanding the broader role of DNA damage repair in cancers has became a basic and attractive strategy for targeted cancer therapy, in particular, raising novel hypothesis or theory in this field on the basis of previous scientists’ findings would be important for future promising druggable emerging targets. In this review, we first illustrate the timeline steps for the understanding the roles of DNA damage repair in the promotion of cancer and cancer therapy developed, then we summarize the mechanisms regarding DNA damage repair associated with targeted cancer therapy, highlighting the specific proteins behind targeting DNA damage repair that initiate functioning abnormally duo to extrinsic harm by environmental DNA damage factors, also, the DNA damage baseline drift leads to the harmful intrinsic targeted cancer therapy. In addition, clinical therapeutic drugs for DNA damage and repair including therapeutic effects, as well as the strategy and scheme of relative clinical trials were intensive discussed. Based on this background, we suggest two hypotheses, namely “environmental gear selection” to describe DNA damage repair pathway evolution, and “DNA damage baseline drift”, which may play a magnified role in mediating repair during cancer treatment. This two new hypothesis would shed new light on targeted cancer therapy, provide a much better or more comprehensive holistic view and also promote the development of new research direction and new overcoming strategies for patients.

Sign in / Sign up

Export Citation Format

Share Document