A Vaccine against Benzimidazole-Derived New Psychoactive Substances That Are More Potent Than Fentanyl

2022 ◽  
Author(s):  
Jinny Claire Lee ◽  
Hyeri Park ◽  
Lisa M. Eubanks ◽  
Beverly Ellis ◽  
Bin Zhou ◽  
...  
Keyword(s):  
New Psychoactive Substances ◽  
Psychoactive Substances

Voltammetric profiling of new psychoactive substances: Piperazine derivatives

2021 ◽  
Vol 883 ◽  
pp. 115054
Author(s):  
D. Martins ◽  
E.M.P.J. Garrido ◽  
F. Borges ◽  
J.M.P.J. Garrido
Keyword(s):  
New Psychoactive Substances ◽  
Psychoactive Substances ◽  
Piperazine Derivatives

scholarly journals Mortality involving New Psychoactive Substances across Europe, 2016- 2017

2021 ◽  
pp. 100016
Author(s):  
Hugo López-Pelayo ◽  
Julian Vicente ◽  
Ana Gallegos ◽  
Andrew McAuley ◽  
Yacin Buyuk ◽  
...  
Keyword(s):  
New Psychoactive Substances ◽  
Psychoactive Substances

scholarly journals Ultra-High Performance Liquid Chromatography-High Resolution Mass Spectrometry and High-Sensitivity Gas Chromatography-Mass Spectrometry Screening of Classic Drugs and New Psychoactive Substances and Metabolites in Urine of Consumers

2021 ◽  
Vol 22 (8) ◽  
pp. 4000
Author(s):  
Emilia Marchei ◽  
Maria Alias Ferri ◽  
Marta Torrens ◽  
Magí Farré ◽  
Roberta Pacifici ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Mobile Phase ◽  
High Performance ◽  
High Resolution Mass Spectrometry ◽  
High Sensitivity ◽  
Gas Chromatography Mass Spectrometry ◽  
New Psychoactive Substances ◽  
Psychoactive Substances ◽  
Resolution Mass

The use of the new psychoactive substances is continuously growing and the implementation of accurate and sensible analysis in biological matrices of users is relevant and fundamental for clinical and forensic purposes. Two different analytical technologies, high-sensitivity gas chromatography-mass spectrometry (GC-MS) and ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS) were used for a screening analysis of classic drugs and new psychoactive substances and their metabolites in urine of formed heroin addicts under methadone maintenance therapy. Sample preparation involved a liquid-liquid extraction. The UHPLC-HRMS method included Accucore™ phenyl Hexyl (100 × 2.1 mm, 2.6 μm, Thermo, USA) column with a gradient mobile phase consisting of mobile phase A (ammonium formate 2 mM in water, 0.1% formic acid) and mobile phase B (ammonium formate 2 mM in methanol/acetonitrile 50:50 (v/v), 0.1% formic acid) and a full-scan data-dependent MS2 (ddMS2) mode for substances identification (mass range 100–1000 m/z). The GC-MS method employed an ultra-Inert Intuvo GC column (HP-5MS UI, 30 m, 250 µm i.d, film thickness 0.25 µm; Agilent Technologies, Santa Clara, CA, USA) and electron-impact (EI) mass spectra were recorded in total ion monitoring mode (scan range 40–550 m/z). Urine samples from 296 patients with a history of opioid use disorder were examined. Around 80 different psychoactive substances and/or metabolites were identified, being methadone and metabolites the most prevalent ones. The possibility to screen for a huge number of psychotropic substances can be useful in suspected drug related fatalities or acute intoxication/exposure occurring in emergency departments and drug addiction services.

Direct classification of new psychoactive substances in seized blotter papers by ATR-FTIR and multivariate discriminant analysis

2017 ◽  
Vol 133 ◽  
pp. 96-103 ◽  
Author(s):  
Leandro S.A. Pereira ◽  
Fernanda L.C. Lisboa ◽  
José Coelho Neto ◽  
Frederico N. Valladão ◽  
Marcelo M. Sena
Keyword(s):  
Discriminant Analysis ◽  
New Psychoactive Substances ◽  
Psychoactive Substances ◽  
Multivariate Discriminant Analysis ◽  
Multivariate Discriminant
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