Mesoporous Silica-Coated Upconversion Nanoparticles Assisted Photodynamic Therapy Using 5-Aminolevulinic Acid: Mechanistic and In Vivo Studies

2022 ◽  
Author(s):  
K. Shitaljit Sharma ◽  
Akhil K. Dubey ◽  
Chandan Kumar ◽  
Prasad P. Phadnis ◽  
Vasanthakumaran Sudarsan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mesoporous Silica ◽  
Aminolevulinic Acid ◽  
In Vivo Studies ◽  
Upconversion Nanoparticles

scholarly journals Sonodynamic and sono-photodynamic therapy in oncology

2019 ◽  
Vol 8 (2) ◽  
pp. 31-46
Author(s):  
D. A. Tzerkovsky ◽  
E. L. Protopovich ◽  
D. S. Stupak
Keyword(s):  
Photodynamic Therapy ◽  
Aminolevulinic Acid ◽  
Pulse Frequency ◽  
Antitumor Efficacy ◽  
In Vivo Studies ◽  
Malignant Neoplasms ◽  
Serious Adverse Events ◽  
Treatment Methods

In the present publication, authors have analyzed the results of using sonodynamic and sono-photodynamic therapy with photosensitizing agents of various classes (hematoporphyrin, 5-aminolevulinic acid, chlorin derivatives, etc.) in experimental oncology. In a number of in vitro and in vivo studies, the high antitumor efficacy of the above treatment methods has been proven. Ultrasonic treatment with a pulse frequency of 1–3 MHz and an intensity of 0.7 to 5 W/cm2 , independently and in combination with photo-irradiation of experimental tumors, can significantly improve the cytotoxic properties of photosensitizers. This became the basisfor testing the methodsin patients with malignant neoplasms of various localizations. Scientists fromSouth-East Asia presented the preliminary results of the use of sonodynamic and sono-photodynamic therapy with photosensitizers in the treatment of malignant pathology of the mammary gland, stomach, esophagus, prostate, lung and brain. Analysis of the obtained data indicates the absence of serious adverse events and an increase in the antitumor efficacy of treatment, which included these treatment methods with chlorin-type photosensitizers. 

scholarly journals A self-assembled Ru–Pt metallacage as a lysosome-targeting photosensitizer for 2-photon photodynamic therapy

2019 ◽  
Vol 116 (41) ◽  
pp. 20296-20302 ◽  
Author(s):  
Zhixuan Zhou ◽  
Jiangping Liu ◽  
Juanjuan Huang ◽  
Thomas W. Rees ◽  
Yiliang Wang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Building Blocks ◽  
Cell Uptake ◽  
Photon Absorption ◽  
In Vivo Studies ◽  
Infrared Light ◽  
Ros Generation ◽  
Multicellular Spheroids

Photodynamic therapy (PDT) is a treatment procedure that relies on cytotoxic reactive oxygen species (ROS) generated by the light activation of a photosensitizer. The photophysical and biological properties of photosensitizers are vital for the therapeutic outcome of PDT. In this work a 2D rhomboidal metallacycle and a 3D octahedral metallacage were designed and synthesized via the coordination-driven self-assembly of a Ru(II)-based photosensitizer and complementary Pt(II)-based building blocks. The metallacage showed deep-red luminescence, a large 2-photon absorption cross-section, and highly efficient ROS generation. The metallacage was encapsulated into an amphiphilic block copolymer to form nanoparticles to encourage cell uptake and localization. Upon internalization into cells, the nanoparticles selectively accumulate in the lysosomes, a favorable location for PDT. The nanoparticles are almost nontoxic in the dark, and can efficiently destroy tumor cells via the generation of ROS in the lysosomes under 2-photon near-infrared light irradiation. The superb PDT efficacy of the metallacage-containing nanoparticles was further validated by studies on 3D multicellular spheroids (MCS) and in vivo studies on A549 tumor-bearing mice.

939 TBr4 and BBr2 as Sensitizers for Photodynamic Therapy Against Human Colorectal Adenocarcinoma – in Vivo Studies

2012 ◽  
Vol 48 ◽  
pp. S226
Author(s):  
M. Laranjo ◽  
A.M. Abrantes ◽  
A.C. Serra ◽  
M. Pineiro ◽  
L. Carvalho ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Colorectal Adenocarcinoma ◽  
In Vivo Studies

scholarly journals In vivo Biocompatibility, Biodistribution and Therapeutic Efficiency of Titania Coated Upconversion Nanoparticles for Photodynamic Therapy of Solid Oral Cancers

Theranostics ◽  
2016 ◽  
Vol 6 (11) ◽  
pp. 1844-1865 ◽  
Author(s):  
Sasidharan Swarnalatha Lucky ◽  
Niagara Muhammad Idris ◽  
Kai Huang ◽  
Jaejung Kim ◽  
Zhengquan Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Upconversion Nanoparticles ◽  
Therapeutic Efficiency ◽  
Oral Cancers

The influence of photodynamic therapy parameters on the inactivation of Candida spp: in vitro and in vivo studies

Laser Physics ◽  
2014 ◽  
Vol 24 (4) ◽  
pp. 045601 ◽  
Author(s):  
F Alves ◽  
E G Mima ◽  
L N Dovigo ◽  
V S Bagnato ◽  
J H Jorge ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
In Vivo Studies ◽  
Candida Spp
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