Combination of Anlotinib and Celecoxib for the Treatment of Abdominal Desmoid Tumor: A Case Report and Literature Review

Desmoid tumor is a rare disease, which is histologically characterized by local invasion, monoclonality, and fibroblast proliferation; and clinically characterized by a variable and often unpredictable course. The treatment of desmoid tumor is mainly surgical resection, but the recurrence rate is high. In recent years, a variety of treatment methods, including endocrine therapy, surgery, radiotherapy, chemotherapy, non-steroidal anti-inflammatory drugs, targeted drugs, interferon and more, have been used and achieved certain curative effects. In addition, in view of the inertia characteristics of desmoid tumor, observation is also a first-line scheme recommended by multiple guidelines. In the past, the research progress of targeted therapy for desmoid tumor is relatively slow and the curative effect is limited. Thus, targeted therapy is usually used as a remedial treatment after the failure of other conventional treatment methods. However, in recent years, with the rapid progress in the basic research of targeted therapy, some new targeted drugs are increasingly used for the clinical treatment of desmoid tumor and have achieved good results. Herein, we described a patient with aggressive fibromatosis in the abdominal cavity. Following a combined treatment using anlotinib and celecoxib, the patient achieved a partial response with mild toxicity. Simultaneously, the patient’s pain symptoms completely disappeared. This case indicates that the combination of anlotinib and NSAIDs could be an effective treatment for desmoid tumor.

Towards Catalysts Prepared by Cold Plasma

Cold (non-equilibrium) plasma techniques have long been used as plasma deposition methods to create new materials, often with unique properties, which cannot be produced any other way, as well as plasma treatment methods for the sophisticated modification of conventional materials [...]

Possibilities of conservative treatment of patients with lymphedema of the extremities (literature review)

The literature review describes various methods for treating patients with lymphedema of the extremities. Statistics show an increase in the incidence and disability of patients with this pathology. However, the possibilities of therapeutic measures in lymphedema are far from perfect.The analysis of literature data showed that the basis of treatment for lymphedema of the extremities is comprehensive conservative therapy with the use of pathogenetically grounded physical, mechanical, and medical methods. In complex schemes of conservative treatment for lymphedema, physiotherapy methods occupy a prominent place. The most common technique among them is regular combined decongestive therapy. This method is recognized by leading experts as the main one in treating patients with lower extremity lymphedema. Commitment of patients to treatment and their social and psychological counseling are of great importance. The choice of the volume and method of surgical intervention requires a difficult and individual assessment of pathological changes developing throughout the course of the disease.Despite certain improvements in treatment methods, lower extremity lymphedema is still an unsolved issue. The experience of most specialists involved in lymphedema treatment demonstrates a reasonable balance between basic conservative and surgical treatment methods. Undoubtedly, results of evaluation of these methods will improve the choice of an optimal technique for treating patients with lymphedema of the extremities.

Prediction and Treatment of Water Leakage Risk Caused by the Dynamic Evolution of Ground Fissures in Gully Terrain

Groundwater leakage in the loess gully terrain is one of the main hazards of coal seam mining at shallow burial depth. The burial depth of the 5−2 coal seam is less than 50 m from the ground in the gully of the study site. The fissures that expand upward after mining can easily penetrate the ground to form a water-conducting channels. During rainy periods, there is a potential risk of groundwater leakage. In order to reveal the characteristics of plane development and the dynamic evolution of gully ground fissures, the typical U-shaped gully in the northern Shaanxi coal mine was studied using the field measurement methods of “On-site measurement” and UAV aerial photography. Based on the experimental platform of ground fissure leakage developed and designed by the team, an indoor test model corresponding to the actual situation was established. In addition, the mathematical models of actual flood inrush, fissure width, and flood flow in the channel were established. The actual mine water flow and the mine drainage capacity were compared and analyzed, thus proposing criteria for classifying gully mining ground fissure collapsed water hazards. These criteria can provide theoretical references for predicting fissure leakage hazard zones in the ground gully of shallow buried coal seams. According to the development height of the water-conducting fissure zone (WCFZ), the treatment methods of ground fissures in gullies under different security conditions were designed, which was applied in the field with good results. The results showed that the treatment methods in this paper could effectively prevent the leakage of groundwater in the gullies along the ground fissures.

Intraoperative Fluoroscopy-Assisted Localization of Small Bowel Gastrointestinal Bleeding

Intraoperative management of refractory small bowel gastrointestinal bleeding continues to present challenges to surgeons, specifically, in localizing the source of bleeding. The need for operative intervention has decreased significantly with improved percutaneous radiologic techniques for embolization with good success rates. When percutaneous treatment methods fail, the surgeon is left with a variety of suboptimal options for localization if the pathologic source is not obvious on external inspection of the small bowel. This report describes a novel method for localizing small bowel gastrointestinal bleeding in those patients who have had previous coil embolization attempts at controlling small bowel gastrointestinal bleeding.