Layered Antimicrobial Selenium Nanoparticle–Calcium Phosphate Coating on 3D Printed Scaffolds Enhanced Bone Formation in Critical Size Defects

2020 ◽  
Vol 12 (50) ◽  
pp. 55638-55648
Author(s):  
Cedryck Vaquette ◽  
Nathalie Bock ◽  
Phong A. Tran
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Critical Size ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Critical Size Defects ◽  
Selenium Nanoparticle ◽  
3D Printed

Osteoconductivity of Zinc-Doped Calcium Phosphate Coating on a 3D-Printed Porous Implant

2017 ◽  
Vol 7 (11) ◽  
pp. 1085-1092
Author(s):  
Wenjing Luo ◽  
Qianyue Sun ◽  
Xiaona Wang ◽  
Yu Guo ◽  
Tianqi Guo ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Porous Implant ◽  
3D Printed

Effect of Silicon-Doped Calcium Phosphate Bone Substitutes on Bone Formation and Osteoblastic Phenotype Expression In Vivo

2014 ◽  
Vol 614 ◽  
pp. 31-34 ◽  
Author(s):  
Christine Knabe ◽  
Marco Lopez Heredia ◽  
Dirk Barnemitz ◽  
Antje Genzel ◽  
Fabian Peters ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Bone Substitute ◽  
Bone Repair ◽  
Critical Size ◽  
Potassium Phosphate ◽  
Critical Size Defects ◽  
Bone Substitute Materials ◽  
Silicon Doped ◽  
Substitute Materials

This study evaluates the effect of two novel particulate silicon-doped calcium phosphate graft materials as compared to the currently clinically used material β-TCP on osteogenesis and bone formation after implantation in critical-size defects the sheep scapula. These materials were developed in order to create biodegradable bone substitute materials that degrade rapidly, but still stimulate osteogenesis at the same time, thereby resulting in bone repair and regeneration with fully functional bone tissue. All bone substitute materials studied facilitated excellent bony regeneration of critical-size defects in the sheep scapula. Of the three grafting materials studied, the calcium alkali orthophosphate material with the crystalline phase Ca2KNa (PO4)2, with a small amorphous portion containing magnesium potassium phosphate and a small addition of sodium magnesium silicate had the greatest stimulatory effect on bone formation and expression of osteogenic markers, while exhibiting the highest biodegradability.

Effect of culture conditions and calcium phosphate coating on ectopic bone formation

Biomaterials ◽  
2013 ◽  
Vol 34 (22) ◽  
pp. 5538-5551 ◽  
Author(s):  
Cédryck Vaquette ◽  
Saso Ivanovski ◽  
Stephen M. Hamlet ◽  
Dietmar W. Hutmacher
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Culture Conditions ◽  
Ectopic Bone Formation ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Ectopic Bone

EFFECT OF ALENDRONATE-CONTAINING COATINGS ON OSTEOINTEGRATION INTO POROUS TANTALUM IN A CORTICAL BONE MODEL

Nano LIFE ◽  
2012 ◽  
Vol 02 (01) ◽  
pp. 1250007 ◽  
Author(s):  
KE DUAN ◽  
YOUXIN HU ◽  
KAREN LONG ◽  
ANDREW TOMS ◽  
HELEN M. BURT ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Drug Dose ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
New Bone Formation ◽  
Implant Fixation ◽  
Porous Tantalum ◽  
High Drug ◽  
Drug Coating

Hip replacement is extensively performed in hips with serious damages. The clinical outcomes of hip implants remain to be improved. Local delivery of bisphosphonates may improve implant fixation by positively affecting local bone modeling. In this study, two alendronate-containing coatings were prepared on porous tantalum by electrolytic deposition. Calcium phosphate coating was deposited and adsorbed with alendronate; the resulting coating had a low drug dose and slow release rate. Solid calcium alendronate coating was also deposited on tantalum; the resulting coating had high drug dose and faster release rate. The effects of the two coatings on new bone formation and implant fixation were studied in the rabbit tibial cortex. Four weeks after implantation, the implants with adsorbed alendronate showed the highest total new bone formation and mechanical fixation, whereas the implants with solid drug coating showed slightly lower fixation and total new bone formation than control bare implants. The improvement by the alendronate-adsorbed calcium phosphate coating provides potentials of enhancing early fixation of porous implants. The solid drug coating warranted further studies to exploit its high drug dose for inhibiting future osteolysis.

Calcium Phosphate Coating on Blast-Treated Titanium Implants by RF Magnetron Sputtering

2009 ◽  
Vol 631-632 ◽  
pp. 211-216 ◽  
Author(s):  
Kyosuke Ueda ◽  
Takayuki Narushima ◽  
Takashi Goto ◽  
T. Katsube ◽  
Hironobu Nakagawa ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Magnetron Sputtering ◽  
Bonding Strength ◽  
Rf Magnetron Sputtering ◽  
Titanium Implants ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Coating Films

Calcium phosphate coating films were fabricated on Ti-6Al-4V plates and screw-type implants with a blast-treated surface using radiofrequency (RF) magnetron sputtering and were evaluated in vitro and in vivo. Amorphous calcium phosphate (ACP) and oxyapatite (OAp) films obtained in this study could cover the blast-treated substrate very efficiently, maintaining the surface roughness. For the in vitro evaluations of the calcium phosphate coating films, bonding strength and alkaline phosphatase (ALP) activity were examined. The bonding strength of the coating films to a blast-treated substrate exceeded 60 MPa, independent of film phases except for the film after post-heat-treatment in silica ampoule. When compared with an uncoated substrate, the increase in the ALP activity of osteoblastic SaOS-2 cells on a calcium phosphate coated substrate was confirmed by a cell culture test. The removal torque of screw-type Ti-6Al-4V implants with a blast-treated surface from the femur of Japanese white rabbit increased with the duration of implantation and it was statistically improved by coating an ACP film 2 weeks after implantation. The in vitro and in vivo studies suggested that the application of the sputtered ACP film as a coating on titanium implants was effective in improving their biocompatibility with bones.

Calcium Phosphate Coated Rapid Prototyped Porous Titanium Scaffolds

2007 ◽  
Vol 361-363 ◽  
pp. 907-910
Author(s):  
Marco A. Lopez-Heredia ◽  
Borhane H. Fellah ◽  
Paul Pilet ◽  
C. Leroux ◽  
M. Dorget ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Calcium Phosphate ◽  
Polarized Light ◽  
Porous Titanium ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Alamar Blue ◽  
Subcutaneous Implantation ◽  
Marrow Mesenchymal Stem Cells ◽  
Rat Bone

Porous Titanium Scaffolds were produced by using a rapid prototyping technique. These scaffolds were either coated or not with a calcium phosphate coating via an eletrodeposition method. Rat bone marrow mesenchymal stem cells were cultured on the scaffolds at a density of 106 cells/scaffold for a period of 3 days. Cell proliferation was measured by using the Alamar Blue assay. The scaffolds were observed by SEM and polarized light microscopy. Constructs were then implanted subcutaneously for 4 weeks in syngenic rats. Cells proliferated well after seeding. After subcutaneous implantation, histology and SEM revealed the presence of uniform coatings as well as Ca and P deposits in the non-coated scaffolds suggesting mineralization.

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