pH-Switchable Coordinative Micelles for Enhancing Cellular Transfection of Biocompatible Polycations

2019 ◽  
Vol 11 (23) ◽  
pp. 20689-20698 ◽  
Author(s):  
Qingyan Zhang ◽  
Zhanwei Zhou ◽  
Chenzi Li ◽  
Pengkai Wu ◽  
Minjie Sun
Keyword(s):  
Cellular Transfection

scholarly journals Different-Length Hydrazone Activated Polymers for Plasmid DNA Condensation and Cellular Transfection

2018 ◽  
Vol 19 (7) ◽  
pp. 2638-2649 ◽  
Author(s):  
Juan M. Priegue ◽  
Irene Lostalé-Seijo ◽  
Daniel Crisan ◽  
Juan R. Granja ◽  
Francisco Fernández-Trillo ◽  
...  
Keyword(s):  
Plasmid Dna ◽  
Dna Condensation ◽  
Cellular Transfection

FEMTOSECOND CELLULAR TRANSFECTION USING A NON DIFFRACTING LIGHT BEAM

2008 ◽  
Author(s):  
X. Tsampoula ◽  
V. Garcés-Chávez ◽  
M. Comrie ◽  
D. J. Stevenson ◽  
B. Agate ◽  
...  
Keyword(s):  
Light Beam ◽  
Cellular Transfection

scholarly journals A General RNA Motif for Cellular Transfection

2012 ◽  
Vol 20 (3) ◽  
pp. 616-624 ◽  
Author(s):  
Maria LB Magalhães ◽  
Michelle Byrom ◽  
Amy Yan ◽  
Linsley Kelly ◽  
Na Li ◽  
...  
Keyword(s):  
Cellular Transfection ◽  
Rna Motif

Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase

2000 ◽  
Vol 279 (3) ◽  
pp. F400-F416 ◽  
Author(s):  
Nicole Defer ◽  
Martin Best-Belpomme ◽  
Jacques Hanoune
Keyword(s):  
Adenylyl Cyclase ◽  
Inhibitory Effect ◽  
Relative Level ◽  
Extracellular Signals ◽  
Physiological Relevance ◽  
A Cell ◽  
The Central Nervous System ◽  
Cellular Transfection ◽  
G Protein Coupled

The present review focuses on the potential physiological regulations involving different isoforms of adenylyl cyclase (AC), the enzymatic activity responsible for the synthesis of cAMP from ATP. Depending on the properties and the relative level of the isoforms expressed in a tissue or a cell type at a specific time, extracellular signals received by the G protein-coupled receptors can be differently integrated. We report here on various aspects of such regulations, emphasizing the role of Ca2+/calmodulin in activating AC1 and AC8 in the central nervous system, the potential inhibitory effect of Ca2+ on AC5 and AC6, and the changes in the expression pattern of the isoforms during development. A particular emphasis is given to the role of cAMP during drug dependence. Present experimental limitations are also underlined (pitfalls in the interpretation of cellular transfection, scarcity of the invalidation models, and so on).

scholarly journals Focused Ultrasound for Increased Delivery of Intranasal DNA Nanoparticles to Rat Brain

2018 ◽  
Author(s):  
Barbara L. Waszczak ◽  
Nathan McDannold ◽  
Mark J. Cooper
Keyword(s):  
Transgene Expression ◽  
Viral Vectors ◽  
Focused Ultrasound ◽  
Route Of Administration ◽  
Viral Gene ◽  
Dna Nanoparticles ◽  
Non Invasive ◽  
Treatment Conditions ◽  
Cellular Transfection ◽  
The Brain

We will investigate whether focused ultrasound (FUS) can increase delivery to the brain of a non-viral gene vector given by the intranasal route of administration. Aim 1 will examine different FUS treatment conditions to determine if FUS can increase total plasmid DNA nanoparticle (NP) delivery and transgene expression in the sonicated regions, the rat substantia nigra and striatum, two brain areas involved in Parkinson's Disease (PD). Aim 2 will test whether FUS improves tissue penetration and alters cellular transfection patterns in the sonicated regions following intranasal doses of DNA NPs. If successful, FUS may enable agents with poor capabilities of crossing the blood-brain barrier (BBB), e.g. neurotrophic factors, viral and non-viral vectors encoding them, to become disease-altering therapies by a non-invasive route of administration.

scholarly journals 3D-printing enabled micro-assembly of a microfluidic electroporation system for 3D tissue engineering

Lab on a Chip ◽  
2019 ◽  
Vol 19 (14) ◽  
pp. 2362-2372 ◽  
Author(s):  
Qingfu Zhu ◽  
Megan Hamilton ◽  
Bryan Vasquez ◽  
Mei He
Keyword(s):  
Tissue Engineering ◽  
Cell Growth ◽  
3D Printing ◽  
Electric Fields ◽  
Micro Assembly ◽  
Cellular Transfection

The LEGO® concept is used to build 3D microchannel networks as a 3D μ-electrotransfection system for efficient exchange of nutrition and waste allowing 3D cell growth, while sustaining uniform 3D electric fields during cellular transfection.

scholarly journals Biophysics and protein corona analysis of Janus cyclodextrin-DNA nanocomplexes. Efficient cellular transfection on cancer cells

2017 ◽  
Vol 1861 (7) ◽  
pp. 1737-1749 ◽  
Author(s):  
M. Martínez-Negro ◽  
G. Caracciolo ◽  
S. Palchetti ◽  
D. Pozzi ◽  
A.L. Capriotti ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Protein Corona ◽  
Cellular Transfection

scholarly journals “Building-block crosslinking” micelles for enhancing cellular transfection of biocompatible polycations

2020 ◽  
Author(s):  
Pengkai Wu ◽  
Shuai Yin ◽  
Tianqing Liu ◽  
Dan Ding ◽  
Kaikai Wang
Keyword(s):  
Building Block ◽  
Cellular Transfection

scholarly journals Intracellular ROS mediates gas plasma-facilitated cellular transfection in 2D and 3D cultures

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Dehui Xu ◽  
Biqing Wang ◽  
Yujing Xu ◽  
Zeyu Chen ◽  
Qinjie Cui ◽  
...  
Keyword(s):  
3D Cultures ◽  
Gas Plasma ◽  
Intracellular Ros ◽  
Cellular Transfection ◽  
2D And 3D
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