Principles of Small-Molecule Transport through Synthetic Nanopores

ACS Nano ◽  
2021 ◽  
Author(s):  
Tim Diederichs ◽  
Katya Ahmad ◽  
Jonathan R. Burns ◽  
Quoc Hung Nguyen ◽  
Zuzanna S. Siwy ◽  
...  
Keyword(s):  
Small Molecule ◽  
Molecule Transport ◽  
Small Molecule Transport

Preparation and characterization of crosslinked poly(vinylimidazolium) anion exchange membranes for artificial photosynthesis

2019 ◽  
Vol 7 (41) ◽  
pp. 23818-23829 ◽  
Author(s):  
Blaine M. Carter ◽  
Laura Keller ◽  
Matthias Wessling ◽  
Daniel J. Miller
Keyword(s):  
Ionic Conductivity ◽  
Ion Exchange ◽  
Water Content ◽  
Small Molecule ◽  
Artificial Photosynthesis ◽  
Anion Exchange Membranes ◽  
Molecule Transport ◽  
Small Molecule Transport ◽  
Low Alcohol

The dependence of small molecule transport on the water content of ion exchange materials frustrates the development of membranes with both high ionic conductivity and low alcohol permeability for artificial photosynthesis devices.

scholarly journals Quantitative Small Molecule Transport after Nanosecond Electric Field Exposures - Experiments and Models

2017 ◽  
Vol 112 (3) ◽  
pp. 219a
Author(s):  
Esin B. Sözer ◽  
C. Florencia Pocetti ◽  
Zachary A. Levine ◽  
P. Thomas Vernier
Keyword(s):  
Electric Field ◽  
Small Molecule ◽  
Molecule Transport ◽  
Small Molecule Transport

scholarly journals Intervertebral Disc Degeneration Is Associated With Aberrant Endplate Remodeling and Reduced Small Molecule Transport

2020 ◽  
Vol 35 (8) ◽  
pp. 1572-1581 ◽  
Author(s):  
Beth G Ashinsky ◽  
Edward D Bonnevie ◽  
Sai A Mandalapu ◽  
Stephen Pickup ◽  
Chao Wang ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Small Molecule ◽  
Intervertebral Disc Degeneration ◽  
Molecule Transport ◽  
Small Molecule Transport

scholarly journals Cells on Pores: A Simulation-Driven Analysis of Transcellular Small Molecule Transport

2010 ◽  
Vol 7 (2) ◽  
pp. 456-467 ◽  
Author(s):  
Xinyuan Zhang ◽  
Nan Zheng ◽  
Peng Zou ◽  
Huaning Zhu ◽  
Juan P. Hinestroza ◽  
...  
Keyword(s):  
Small Molecule ◽  
Molecule Transport ◽  
Small Molecule Transport

scholarly journals Asymmetric Patterns of Small Molecule Transport After Nanosecond and Microsecond Electropermeabilization

2017 ◽  
Vol 251 (2) ◽  
pp. 197-210 ◽  
Author(s):  
Esin B. Sözer ◽  
C. Florencia Pocetti ◽  
P. Thomas Vernier
Keyword(s):  
Small Molecule ◽  
Molecule Transport ◽  
Small Molecule Transport

scholarly journals Rapid toxin sequestration modifies poison frog physiology

2021 ◽  
pp. jeb.230342
Author(s):  
Lauren A. O'Connell ◽  
Jeremy D. O'Connell ◽  
Joao A. Paulo ◽  
Sunia A. Trauger ◽  
Steven P. Gygi ◽  
...  
Keyword(s):  
Small Molecule ◽  
Chemical Defenses ◽  
Protein Abundance ◽  
Poison Frog ◽  
Poison Frogs ◽  
Toxin Binding ◽  
Physiological Adaptations ◽  
Molecule Transport ◽  
Protein Classes ◽  
Small Molecule Transport

Poison frogs sequester chemical defenses from their diet of leaf litter arthropods for defense against predation. Little is known about the physiological adaptations that confer this unusual bioaccumulation ability. We conducted an alkaloid-feeding experiment with the Diablito poison frog (Oophaga sylvatica) to determine how quickly alkaloids are accumulated and how toxins modify frog physiology using quantitative proteomics. Diablito frogs rapidly accumulated the alkaloid decahydroquinoline within four days, and dietary alkaloid exposure altered protein abundance in the intestines, liver, and skin. Many proteins that increased in abundance with decahydroquinoline accumulation are plasma glycoproteins, including the complement system and the toxin-binding protein saxiphilin. Other protein classes that change in abundance with decahydroquinoline accumulation are membrane proteins involved in small molecule transport and metabolism. Overall, this work shows poison frogs can rapidly accumulate alkaloids, which alter carrier protein abundance, initiate an immune response, and alter small molecule transport and metabolism dynamics across tissues.

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