Recent Progress in Fluorescent Sensors for Drug-Induced Liver Injury Assessment

ACS Sensors ◽  
2021 ◽  
Author(s):  
Jiao Chen ◽  
Dongyu Huang ◽  
Mengyao She ◽  
Zesi Wang ◽  
Xi Chen ◽  
...  
Keyword(s):  
Liver Injury ◽  
Recent Progress ◽  
Fluorescent Sensors ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Injury Assessment

scholarly journals Hepatitis E Virus, A Diagnosis to Consider in Drug Induced Liver Injury Assessment

2017 ◽  
Vol 39 (8) ◽  
pp. e56-e57
Author(s):  
J. Sanabria-Cabrera ◽  
R. Sanjuan-Jiménez ◽  
C. Stephens ◽  
M. Robles-Díaz ◽  
A. Ortega-Alonso ◽  
...  
Keyword(s):  
Liver Injury ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Injury Assessment

scholarly journals Redrawing the Map to Novel DILI Biomarkers in Circulation: Where Are We, Where Should We Go, and How Can We Get There?

Livers ◽  
2021 ◽  
Vol 1 (4) ◽  
pp. 286-293
Author(s):  
Joel H. Vazquez ◽  
Mitchell R. McGill
Keyword(s):  
Liver Injury ◽  
Recent Progress ◽  
Biomarker Discovery ◽  
Short Review ◽  
Discovery Process ◽  
Circulating Biomarkers ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
New Biomarkers ◽  
Biomarker Research

Circulating biomarkers of drug-induced liver injury (DILI) have been a focus of research in hepatology over the last decade, and several novel DILI biomarkers that hold promise for certain applications have been identified. For example, glutamate dehydrogenase holds promise as a specific biomarker of liver injury in patients with concomitant muscle damage. It may also be a specific indicator of mitochondrial damage. In addition, microRNA-122 is sensitive for early detection of liver injury in acetaminophen overdose patients. However, recent events in the field of DILI biomarker research have provided us with an opportunity to step back, consider how biomarker discovery has been done thus far, and determine how to move forward in a way that will optimize the discovery process. This is important because major challenges remain in the DILI field and related areas that could be overcome in part by new biomarkers. In this short review, we briefly describe recent progress in DILI biomarker discovery and development, identify current needs, and suggest a general approach to move forward.

Leberschaden unter oraler Antikoagulation, Statin- und ACE-Hemmertherapie

Praxis ◽  
2010 ◽  
Vol 99 (21) ◽  
pp. 1259-1265 ◽  
Author(s):  
Bruggisser ◽  
Terraciano ◽  
Rätz Bravo ◽  
Haschke
Keyword(s):  
Liver Injury ◽  
Wird Eine ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Ein 71-jähriger Patient stellt sich mit Epistaxis und ikterischen Skleren auf der Notfallstation vor. Der Patient steht unter einer Therapie mit Phenprocoumon, Atorvastatin und Perindopril. Anamnestisch besteht ein langjähriger Alkoholabusus. Laborchemisch werden massiv erhöhte Leberwerte (ALAT, Bilirubin) gesehen. Der INR ist unter oraler Antikoagulation und bei akuter Leberinsuffizienz >12. Die weiterführenden Abklärungen schliessen eine Virushepatitis und eine Autoimmunhepatitis aus. Nachdem eine Leberbiopsie durchgeführt werden kann, wird eine medikamentös-toxische Hepatitis, ausgelöst durch die Komedikation von Atorvastatin, Phenprocoumon und Perindopril bei durch Alkohol bereits vorgeschädigter Leber diagnostiziert. Epidemiologie, Pathophysiologie und Klink der medikamentös induzierten Leberschäden (drug induced liver injury, DILI), speziell von Coumarinen, Statinen und ACE-Hemmern werden im Anschluss an den Fallbericht diskutiert.

Drug-induced liver injury network (DILIN)

Hepatology ◽  
2004 ◽  
Vol 40 (4) ◽  
pp. 773-773 ◽  
Author(s):  
Jay H. Hoofnagle
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Drug induced liver injury associated with Flupirtine in 6 cases

2011 ◽  
Vol 49 (08) ◽  
Author(s):  
C Agne ◽  
K Rifai ◽  
HH Kreipe ◽  
MP Manns ◽  
F Puls
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury

WISP1 modulates immune cell infiltration upon drug-induced liver injury (DILI)

2015 ◽  
Vol 53 (12) ◽  
Author(s):  
AB Widera ◽  
L Pütter ◽  
S Leserer ◽  
G Campos ◽  
K Rochlitz ◽  
...  
Keyword(s):  
Liver Injury ◽  
Immune Cell ◽  
Cell Infiltration ◽  
Immune Cell Infiltration ◽  
Drug Induced ◽  
Drug Induced Liver Injury
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