Novel Vanilloid Receptor-1 Antagonists:  2. Structure−Activity Relationships of 4-Oxopyrimidines Leading to the Selection of a Clinical Candidate

Structure Activity ◽

Vanilloid Receptor 1 ◽

Selection Of ◽

Structure–activity relationships of 1,4-dihydropyridines that act as enhancers of the vanilloid receptor 1 (TRPV1)

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2008.08.048 ◽

2008 ◽

Vol 16 (20) ◽

pp. 9349-9358 ◽

Cited By ~ 20

Author(s):

Eun Joo Roh ◽

Jason M. Keller ◽

Zoltan Olah ◽

Michael J. Iadarola ◽

Kenneth A. Jacobson

Keyword(s):

Vanilloid Receptor ◽

Structure Activity ◽

Vanilloid Receptor 1

Analysis of structure–activity relationships with the N-(3-acyloxy-2-benzylpropyl)-N′-[4-(methylsulfonylamino)benzyl]thiourea template for vanilloid receptor 1 antagonism

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2004.04.040 ◽

2004 ◽

Vol 12 (13) ◽

pp. 3411-3420 ◽

Cited By ~ 10

Author(s):

Jeewoo Lee ◽

Su Yeon Kim ◽

Jiyoun Lee ◽

Myungsim Kang ◽

Min-Jung Kil ◽

...

Keyword(s):

Vanilloid Receptor ◽

Structure Activity ◽

Vanilloid Receptor 1

ChemInform Abstract: Design, Synthesis and Structure-Activity Relationships of (Indo-3-yl) Heterocyclic Derivatives as Agonists of the CB1 Receptor. Discovery of a Clinical Candidate.

ChemInform ◽

10.1002/chin.201134210 ◽

2011 ◽

Vol 42 (34) ◽

pp. no-no

Author(s):

Paul Ratcliffe ◽

et al. et al.

Keyword(s):

Cb1 Receptor ◽

Design Synthesis ◽

Structure Activity ◽

Heterocyclic Derivatives ◽

Novel Vanilloid Receptor-1 Antagonists: 3. The Identification of a Second-Generation Clinical Candidate with Improved Physicochemical and Pharmacokinetic Properties

Journal of Medicinal Chemistry ◽

10.1021/jm070191h ◽

2007 ◽

Vol 50 (15) ◽

pp. 3528-3539 ◽

Cited By ~ 37

Author(s):

Hui-Ling Wang ◽

Jodie Katon ◽

Chenera Balan ◽

Anthony W. Bannon ◽

Charles Bernard ◽

...

Keyword(s):

Second Generation ◽

Vanilloid Receptor ◽

Vanilloid Receptor 1 ◽

Pharmacokinetic Properties ◽

β-Lactamase-stable penicillins. Synthesis and structure–activity relationships of (Z)-alkyloxyimino penicillins; selection of BRL 44154

Journal of the Chemical Society Perkin Transactions 1 ◽

10.1039/p19910000881 ◽

1991 ◽

pp. 881-891 ◽

Cited By ~ 12

Author(s):

Pamela Brown ◽

Stephen H. Calvert ◽

Pauline C. A. Chapman ◽

Suzanne C. Cosham ◽

A. John Eglington ◽

...

Keyword(s):

Structure Activity ◽

Selection Of

N -[4-(Methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: analysis of structure–activity relationships for the ‘C-Region’

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2003.10.047 ◽

2004 ◽

Vol 12 (2) ◽

pp. 371-385 ◽

Cited By ~ 23

Author(s):

Jeewoo Lee ◽

Sang-Uk Kang ◽

Ju-Ok Lim ◽

Hyun-Kyung Choi ◽

Mi-kyung Jin ◽

...

Keyword(s):

Vanilloid Receptor ◽

Receptor Antagonists ◽

Structure Activity

Adapted Transfer of Distance Measures for Quantitative Structure-Activity Relationships and Data-Driven Selection of Source Datasets

The Computer Journal ◽

10.1093/comjnl/bxs092 ◽

2012 ◽

Vol 56 (3) ◽

pp. 274-288 ◽

Cited By ~ 4

Author(s):

T. Girschick ◽

U. Ruckert ◽

S. Kramer,

Keyword(s):

Distance Measures ◽

Data Driven ◽

Quantitative Structure ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Selection Of

Analysis of structure–activity relationships for the ‘B-region’ of N -(3-acyloxy-2-benzylpropyl)- N ′ -[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: discovery of an N -hydroxythiourea analogue with potent analgesic activity

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2004.02.002 ◽

2004 ◽

Vol 14 (9) ◽

pp. 2291-2297 ◽

Cited By ~ 9

Author(s):

Jeewoo Lee ◽

Sang-Uk Kang ◽

Hyun-Kyung Choi ◽

Jiyoun Lee ◽

Ju-Ok Lim ◽

...

Keyword(s):

Analgesic Activity ◽

Vanilloid Receptor ◽

Receptor Antagonists ◽

Structure Activity

ChemInform Abstract: β-Lactamase-Stable Penicillins. Synthesis and Structure-Activity Relationships of (Z)-Alkyloxyimino Penicillins; Selection of BRL 44154.

ChemInform ◽

10.1002/chin.199128242 ◽

2010 ◽

Vol 22 (28) ◽

pp. no-no

Author(s):

P. BROWN ◽

S. H. CALVERT ◽

P. C. A. CHAPMAN ◽

S. C. COSHAM ◽

A. J. EGLINGTON ◽

...

Keyword(s):

Structure Activity ◽

Selection Of

272 8-(1-Anilino)ethyl)-2-morpholino-4-oxo-4H-chromene-6-carboxamides as PI3Kbeta/delta inhibitors: structure–activity relationships and identification of AZD8186, a clinical candidate for the treatment of PTEN deficient tumours

European Journal of Cancer ◽

10.1016/s0959-8049(14)70398-3 ◽

2014 ◽

Vol 50 ◽

pp. 90-91

Author(s):

B. Barlaam ◽

S. Cosulich ◽

S. Degorce ◽

M. Fitzek ◽

S. Green ◽

...

Keyword(s):

Structure Activity ◽