Ethanesulfohydroxamic Acid Ester Prodrugs of Nonsteroidal Anti-inflammatory Drugs (NSAIDs): Synthesis, Nitric oxide and Nitroxyl Release, Cyclooxygenase Inhibition, Anti-inflammatory, and Ulcerogenicity Index Studies

2011 ◽  
Vol 54 (5) ◽  
pp. 1356-1364 ◽  
Author(s):  
Zhangjian Huang ◽  
Carlos A. Velázquez ◽  
Khaled R. A. Abdellatif ◽  
Morshed A. Chowdhury ◽  
Julie A. Reisz ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Acid Ester ◽  
Cyclooxygenase Inhibition ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Ester Prodrugs

Neuroprotective effects of non-steroidal anti-inflammatory drugs by direct scavenging of nitric oxide radicals

2001 ◽  
Vol 76 (6) ◽  
pp. 1895-1904 ◽  
Author(s):  
Masato Asanuma ◽  
Sakiko Nishibayashi-Asanuma ◽  
Ikuko Miyazaki ◽  
Masahiro Kohno ◽  
Norio Ogawa
Keyword(s):  
Nitric Oxide ◽  
Neuroprotective Effects ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals The cytoprotective effect of a nitric oxide donor drug on gastric mucous membrane of rats treated with ketoprofen, a non-steroidal anti-inflammatory drug

2006 ◽  
Vol 43 (3) ◽  
pp. 233-237 ◽  
Author(s):  
Afonso Luiz Villa ◽  
Ceneviva Reginaldo ◽  
Fernanda Viaro ◽  
Fernando Ramalho ◽  
Antonio Dorival Campos ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Isosorbide Dinitrate ◽  
Saline Solution ◽  
Isotonic Saline ◽  
Nitric Oxide Donor ◽  
Group Iii ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Gastric Mucous ◽  
Lesion Index

BACKGROUND: Non-steroidal anti-inflammatory drugs are considered today a very important group of medication, with a wide variety of therapeutic use, in different areas of modern medicine. Despite their beneficial effects on the patient, these drugs show a high incidence of side effects, mainly in the gastrointestinal tract. The physiopathological mechanisms of non-steroidal anti-inflammatory drugs induced lesions and the gastric mucosa defense mechanism became an important source for medical research, especially those which try to evaluate the role of nitric oxide as a cytoprotective agent. AIM: To define a possible cytoprotective effect of a nitric oxide donor, isosorbide dinitrate, on the gastric mucous of rats submitted to non-steroidal anti-inflammatory drugs ketoprofen treatment. METHODS: Adult male Wistar rats, previously submitted to starvation for 24 hours and divided in three groups: group I (standard): animals that received isotonic saline solution intragastric by gavage and intravenous. Group II (control-ketoprofen): animals that received isotonic saline solution intragastric by gavage and ketoprofen intravenous. Group III (nitrate/ketoprofen): animals that received 2mM solution of isosorbide dinitrate intragastric by gavage and ketoprofen intravenous. Later on, these animals were sacrificed and had their stomach removed and submitted to macroscopical, microscopical and biochemical studies. The evaluated parameters were: a) gastric lesion index; b) gastric mucous layer thickness; c) gastric tissue nitrate/nitrite (NOx) concentration and d) gastric tissue malondialdehyde concentration. RESULTS: a) Gastric lesion index evaluation showed a smaller statistically significant incidence on the animals of group III; b) group III showed a thicker mucous layer, which also was statistically significant, when compared to group II; c) the variation on tissue nitrate/nitrite concentration was similar in all three groups, without statistical significance when compared to each other. CONCLUSION: Isosorbide dinitrate has a cytoprotective activity on the gastric mucosa of rats submitted to ketoprofen action.

scholarly journals Nitric Oxide Regulates Immune Cell Bioenergetic: A Mechanism to Understand Immunomodulatory Functions of Nitric Oxide-Releasing Anti-Inflammatory Drugs

2004 ◽  
Vol 173 (2) ◽  
pp. 874-882 ◽  
Author(s):  
Stefano Fiorucci ◽  
Andrea Mencarelli ◽  
Eleonora Distrutti ◽  
Monia Baldoni ◽  
Piero del Soldato ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Immune Cell ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Nitric Oxide Releasing

Nitric Oxide Release Is Not Required to Decrease the Ulcerogenic Profile of Nonsteroidal Anti-inflammatory Drugs

2012 ◽  
Vol 55 (2) ◽  
pp. 688-696 ◽  
Author(s):  
Sarthak Jain ◽  
Susan Tran ◽  
Mohamed A. M. El Gendy ◽  
Khosrow Kashfi ◽  
Paul Jurasz ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Release ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

THE POTENTIAL ROLE OF NITRIC OXIDE DONATING NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NO-NSAIDs) AS NEOADJUVENT THERAPY PRIOR TO IRRADIATION OF HYPOXIC PROSTATE CANCER CELLS

2008 ◽  
Vol 179 (4S) ◽  
pp. 43-43 ◽  
Author(s):  
Grant D Stewart ◽  
Jyoti Nanda ◽  
Jill G Christie ◽  
David JG Brown ◽  
Antony CP Riddick ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Nitric Oxide ◽  
Cancer Cells ◽  
Potential Role ◽  
Prostate Cancer Cells ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Gastroprotective and ulcer healing effects of nitric oxide-releasing non-steroidal anti-inflammatory drugs

2000 ◽  
Vol 32 (7) ◽  
pp. 583-594 ◽  
Author(s):  
T. Brzozowski ◽  
P.Ch. Konturek ◽  
S.J. Konturek ◽  
Z. Sliwowski ◽  
D. Drozdowicz ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Ulcer Healing ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Nitric Oxide Releasing
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