scholarly journals Discovery of Naturally Occurring Aurones That Are Potent Allosteric Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase

2011 ◽  
Vol 54 (15) ◽  
pp. 5395-5402 ◽  
Author(s):  
Romain Haudecoeur ◽  
Abdelhakim Ahmed-Belkacem ◽  
Wei Yi ◽  
Antoine Fortuné ◽  
Rozenn Brillet ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Rna Polymerase ◽  
Hepatitis C Virus Rna ◽  
Allosteric Inhibitors ◽  
Rna Dependent Rna Polymerase ◽  
Naturally Occurring ◽  
Virus Rna

B-ring modified aurones as promising allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase

2014 ◽  
Vol 80 ◽  
pp. 579-592 ◽  
Author(s):  
Amel Meguellati ◽  
Abdelhakim Ahmed-Belkacem ◽  
Wei Yi ◽  
Romain Haudecoeur ◽  
Marie Crouillère ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Rna Polymerase ◽  
Hepatitis C Virus Rna ◽  
Allosteric Inhibitors ◽  
Rna Dependent Rna Polymerase ◽  
Virus Rna

THE QSAR RESEARCH ON AURONE INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE BY APPLYING MULTI-DIMENSIONAL SCALING METHOD

2013 ◽  
Vol 06 (01) ◽  
pp. 1250062
Author(s):  
YONG-HONG HU ◽  
BAO-HUA ZHANG
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Rna Polymerase ◽  
Hcv Rna ◽  
Training Set ◽  
Rna Dependent Rna Polymerase ◽  
Dimensional Scaling ◽  
Naturally Occurring ◽  
Virus Rna ◽  
Multi Dimensional Scaling

In this paper, we take naturally occurring 2-benzylidenebenzofuran-3-ones (aurones) inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) as an example to study the Multi-dimensional scaling (MDS) method for structure-activity relationship. By analyzing training set molecules, our MDS method combined with a PROXSCAL algorithm can predict inhibitory activity of most compounds correctly. Thus, a new sample's activity can be estimated and judged conveniently, and whether it should be synthesized can be known. The MDS method is applicable to optimize the structure for a compound and to provide suggestions for drug design.

Activation of protein kinase R by hepatitis C virus RNA-dependent RNA polymerase

Virology ◽  
2019 ◽  
Vol 529 ◽  
pp. 226-233 ◽  
Author(s):  
Ryosuke Suzuki ◽  
Mami Matsuda ◽  
Takashi Shimoike ◽  
Koichi Watashi ◽  
Hideki Aizaki ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Protein Kinase ◽  
Rna Polymerase ◽  
Protein Kinase R ◽  
Hepatitis C Virus Rna ◽  
Rna Dependent Rna Polymerase ◽  
Virus Rna

New Non-nucleoside Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase

2004 ◽  
Vol 69 (7) ◽  
pp. 782-788 ◽  
Author(s):  
A. V. Ivanov ◽  
M. V. Kozlov ◽  
A. O. Kuzyakin ◽  
D. A. Kostyuk ◽  
V. L. Tunitskaya ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Rna Polymerase ◽  
Hepatitis C Virus Rna ◽  
Rna Dependent Rna Polymerase ◽  
Virus Rna ◽  
Nucleoside Inhibitors
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