Major trends in information and communication technology (ICT) are transforming the global commercial and technology landscape. Since 1945, the US market has been the most consistent agenda setter for the global market. But now, as economic gloom haunts the world, and as a new President settles in the United States, predictions abound that American dominance in international relations will give way to the leadership of China or others. However, if the United States acts vigorously on the policy front, it can maintain its international leadership position until at least 2025. In addition, the information revolution has also accelerated the changing of international actors’ roles. This is because the web and the information revolution had resulted in tremendous security, political, economic, social, and cultural consequences, which altered the roles of countries, companies, non-governmental actors, and international institutions in the conduct of international relations. ICTs can also leave a significant impact on foreign policy, as these can affect democratic and authoritarian rule, as well as give rise to the “CNN effect,” which is a relatively recent phenomenon which has a tendency to alter the extent, depth, and speed of the new global media. As the ICT revolution spreads across the planet it also resets the international relations playing field, with significant consequences for security, and political, economic, social, and cultural interactions.