Neural System Interactions Within the Context of Learning and Memory: Time Dependent Relationship Between the Dorsal Hippocampus and the Prefrontal Cortex in Spatial Memory

2003 ◽  
Author(s):  
Raymond Kesner
Keyword(s):  
Prefrontal Cortex ◽  
Spatial Memory ◽  
Learning And Memory ◽  
Dorsal Hippocampus ◽  
Neural System ◽  
Time Dependent ◽  
Dependent Relationship ◽  
Memory Time ◽  
Context Of Learning

Dorsal hippocampus and medial prefrontal cortex each contribute to the retrieval of a recent spatial memory in rats

2014 ◽  
Vol 221 (1) ◽  
pp. 91-102 ◽  
Author(s):  
Thibault Cholvin ◽  
Michaël Loureiro ◽  
Raphaelle Cassel ◽  
Brigitte Cosquer ◽  
Karin Herbeaux ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Spatial Memory ◽  
Medial Prefrontal Cortex ◽  
Dorsal Hippocampus

scholarly journals Pharmacological Blockade of PPARα Exacerbates Inflammatory Pain-Related Impairment of Spatial Memory in Rats

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 610
Author(s):  
Jessica C. Gaspar ◽  
Catherine Healy ◽  
Mehnaz I. Ferdousi ◽  
Michelle Roche ◽  
David P. Finn
Keyword(s):  
Spatial Memory ◽  
Cognitive Processing ◽  
Inflammatory Pain ◽  
Dorsal Hippocampus ◽  
Memory Function ◽  
Intraperitoneal Administration ◽  
Compensatory Mechanism ◽  
Chronic Inflammatory Pain ◽  
Pharmacological Blockade ◽  
Innate Anxiety

Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that exist in three isoforms: PPARα, PPARβ/δ and PPARγ. Studies suggest that the PPAR signalling system may modulate pain, anxiety and cognition. The aim of the present study was to investigate whether endogenous signalling via PPARs differentially modulates innate anxiety responses and mnemonic function in the presence and absence of inflammatory pain. We examined the effects of intraperitoneal administration of GW6471 (PPARα antagonist), GSK0660 (PPARβ/δ antagonist), GW9662 (PPARγ antagonist), and N-palmitoylethanolamide (PEA) on rat behaviour in the elevated plus maze (EPM), open field (OF), light-dark box (LDB), and novel object recognition (NOR) tests in the presence or absence of chronic inflammatory pain. Complete Freund’s Adjuvant (CFA)-injected rats exhibited impaired recognition and spatial mnemonic performance in the NOR test and pharmacological blockade of PPARα further impaired spatial memory in CFA-treated rats. N-oleoylethanolamide (OEA) levels were higher in the dorsal hippocampus in CFA-injected animals compared to their counterparts. The results suggest a modulatory effect of CFA-induced chronic inflammatory pain on cognitive processing, but not on innate anxiety-related responses. Increased OEA-PPARα signalling may act as a compensatory mechanism to preserve spatial memory function following CFA injection.

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