This chapter summarizes the current state of practice in the application of information technology (IT) for knowledge exchange amongst key health care stakeholders: healthcare consumers, health service providers, and researchers. The objectives are to review the practices that facilitate collaboration amongst stakeholders, the role of new technologies in facilitating exchange of information amongst key stakeholders, and the role of three key stakeholders as creators, consumers, and/or translators of information. The emphasis is on exploring an increasingly collaborative exchange of knowledge online.