Simultaneous Determination of Several Charge-transfer Complex Association Constants using Nuclear Magnetic Resonance

Nature ◽  
1967 ◽  
Vol 213 (5076) ◽  
pp. 591-592 ◽  
Author(s):  
R. FOSTER ◽  
C. A. FYFE
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Charge Transfer ◽  
Magnetic Resonance ◽  
Simultaneous Determination ◽  
Charge Transfer Complex ◽  
Association Constants ◽  
Nuclear Magnetic

Simultaneous Determination of Vitamins B1 and B6 by Nuclear Magnetic Resonance Spectrometry

1978 ◽  
Vol 61 (1) ◽  
pp. 111-116
Author(s):  
Saad S M Hassan
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Simultaneous Determination ◽  
Pharmaceutical Preparations ◽  
Resonance Method ◽  
Nuclear Magnetic Resonance Method ◽  
Vitamin B2 ◽  
Peak Areas ◽  
Nuclear Magnetic

Abstract A new, simple, and rapid quantitative nuclear magnetic resonance method has been developed for simultaneous determination of vitamins B1 and B6 in mixtures in the presence of vitamin B2 without prior separation. The peak areas of 2 resonance lines at δ2.55 and 2.65 ppm are used. Maleic acid (δ = 6.6 ppm) is used as a reference standard, and the integral peak areas are referred to it. The method was tested with synthetically prepared mixtures containing from 0.05 to 1.5mM of each vitamin and was applied to the analysis of some pharmaceutical preparations. The results show an average recovery of 98% of both vitamins. Vitamin B2 does not interfere, if present.

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