scholarly journals Antisense oligonucleotide to insulin-like growth factor II induces apoptosis in human ovarian cancer AO cell line

Cell Research ◽  
1998 ◽  
Vol 8 (2) ◽  
pp. 159-165 ◽  
Author(s):  
De Ling Yin ◽  
Lu Pu ◽  
Gang Pei
Keyword(s):  
Ovarian Cancer ◽  
Growth Factor ◽  
Cell Line ◽  
Antisense Oligonucleotide ◽  
Human Ovarian Cancer ◽  
Insulin Like Growth Factor ◽  
Factor Ii

Biosynthesis of 10 kDa and 7.5 kDa insulin-like growth factor II in a human rhabdomyosarcoma cell line

1993 ◽  
Vol 93 (1) ◽  
pp. 87-95 ◽  
Author(s):  
Finn C. Nielsen ◽  
Gisela Haselbacher ◽  
Jan Christiansen ◽  
Mats Lake ◽  
Mette Grønborg ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cell Line ◽  
Insulin Like Growth Factor ◽  
Rhabdomyosarcoma Cell Line ◽  
Factor Ii ◽  
Rhabdomyosarcoma Cell

scholarly journals Humoral Autoimmune Responses to Insulin-Like Growth Factor II mRNA-Binding Proteins IMP1 and p62/IMP2 in Ovarian Cancer

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Xinxin Liu ◽  
Hua Ye ◽  
Liuxia Li ◽  
Wenjie Li ◽  
Yi Zhang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Growth Factor ◽  
Binding Proteins ◽  
Immunofluorescence Assay ◽  
Enzyme Linked Immunosorbent Assay ◽  
Insulin Like Growth Factor ◽  
Mrna Binding Proteins ◽  
Normal Individuals ◽  
Factor Ii ◽  
Mrna Binding

Ovarian cancer is one of the leading causes of cancer-related deaths among women. There is an urgent need of better approaches for the identification of appropriate biomarkers in the early detection of ovarian cancer. The aim of this study was to elucidate the significance of autoantibodies against insulin-like growth factor II mRNA-binding proteins (IMPs) in patients with ovarian cancer. In this study, autoantibody responses to two members (IMP1 and p62/IMP2) of IMPs were evaluated by enzyme-linked immunosorbent assay (ELISA), western blotting, and indirect immunofluorescence assay in sera from patients with ovarian cancer and normal human individuals. The results have demonstrated that both IMP1 and p62/IMP2 can induce relatively higher frequency of autoantibody responses in patients with ovarian cancer (26.5% and 29.4%) compared to normal individuals(P<0.01). Our preliminary data suggest that IMP1 and p62/IMP2 can stimulate autoimmune responses in ovarian cancer, and anti-IMP1 and anti-p62/IMP2 autoantibodies could be used as potential biomarkers in immunodiagnosis of ovarian cancer.

Retinoic acid regulates insulin-like growth factor II expression in a neuroblastoma cell line.

Endocrinology ◽  
1992 ◽  
Vol 130 (6) ◽  
pp. 3669-3676 ◽  
Author(s):  
K Matsumoto ◽  
C Gaetano ◽  
W H Daughaday ◽  
C J Thiele
Keyword(s):  
Retinoic Acid ◽  
Growth Factor ◽  
Cell Line ◽  
Neuroblastoma Cell ◽  
Neuroblastoma Cell Line ◽  
Insulin Like Growth Factor ◽  
Factor Ii

Promoter-specific transcription of insulin-like growth factor-II in epithelial ovarian cancer

2006 ◽  
Vol 103 (3) ◽  
pp. 990-995 ◽  
Author(s):  
Lingeng Lu ◽  
Dionyssios Katsaros ◽  
Andrew Wiley ◽  
I.A. Rigault de la Longrais ◽  
Manuela Puopolo ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Growth Factor ◽  
Epithelial Ovarian Cancer ◽  
Insulin Like Growth Factor ◽  
Factor Ii

scholarly journals Insulin-like growth factor-II gene expression in a rat insulin-producing beta-cell line (INS-1) is regulated by glucose

Diabetologia ◽  
1995 ◽  
Vol 38 (8) ◽  
pp. 927-935
Author(s):  
M. Asfari ◽  
W. De ◽  
M. N�el ◽  
P. E. Holthuizen ◽  
P. Czernichow
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Beta Cell ◽  
Cell Line ◽  
Insulin Like Growth Factor ◽  
Beta Cell Line ◽  
Factor Ii

scholarly journals Hypermethylation of let-7a-3 in Epithelial Ovarian Cancer Is Associated with Low Insulin-like Growth Factor-II Expression and Favorable Prognosis

2007 ◽  
Vol 67 (21) ◽  
pp. 10117-10122 ◽  
Author(s):  
Lingeng Lu ◽  
Dionyssios Katsaros ◽  
Irene A. Rigault de la Longrais ◽  
Olga Sochirca ◽  
Herbert Yu
Keyword(s):  
Ovarian Cancer ◽  
Growth Factor ◽  
Epithelial Ovarian Cancer ◽  
Insulin Like Growth Factor ◽  
Favorable Prognosis ◽  
Factor Ii

The binding of insulin-like growth factor II to the erythroleukemia cell line K562

1984 ◽  
Vol 4 (12) ◽  
pp. 1071-1077 ◽  
Author(s):  
Michael Tally ◽  
Tang Xin-Zhi ◽  
Gösta Enberg ◽  
Kerstin Hall
Keyword(s):  
Growth Factor ◽  
Cell Line ◽  
Specific Binding ◽  
Affinity Constant ◽  
Scatchard Analysis ◽  
Insulin Like Growth Factor ◽  
Factor Ii ◽  
Igf I ◽  
Erythroleukemia Cell ◽  
High Concentrations

The erythroleukemia cell line K562 was previously shown to have specific binding sites for insulin but not for insulin-like growth factor I (IGF-I). In this study the presence of specific receptors for insulin-like growth factor II (IGFqI) is established. Scatchard analysis of the competition curve for IGF-II disclosed a non-cooperative binding kinetic with a calculated affinity constant of 2.4 × 108 M−1 and a receptor number of 4.8 × 104 sites/cell. IGF-I displayed 10% crossreactivity over the IGF-II receptor but insulin did not crossreact at all. Instead insulin, present in high concentrations, enhanced the binding of IGF-II. The presence of IGF II but not IGF-I receptors makes the K562 cell line suitable for studying properties of the type-2 receptor.

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