Monoclonal antibody against CXCL-10/IP-10 ameliorates influenza A (H1N1) virus induced acute lung injury

Influenza A virus infections can cause acute lung injury (ALI) in humans; thus, the identification of potent antiviral agents is urgently required. Herein, the effects of salidroside on influenza A virus-induced ALI were investigated in a murine model. BALB/c mice were intranasally inoculated with H1N1 virus and treated with salidroside. The results of this study show that salidroside treatment (30 and 60 mg/kg) significantly attenuated the H1N1 virus-induced histological alterations in the lung and inhibited inflammatory cytokine production. Salidroside also decreased the wet/dry ratio, viral titers, and Toll-like receptor 4 expression in the lungs. Therefore, salidroside may represent a potential therapeutic reagent for the treatment of influenza A virus-induced ALI.

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Influenza A (H1N1): the first hit for transfusion-related acute lung injury?

Critical Care ◽

10.1186/cc13304 ◽

2014 ◽

Vol 18 (Suppl 1) ◽

pp. P114

Author(s):

F Piza ◽

F Carvalho ◽

H Li ◽

T Crochemore ◽

R Rodrigues

Keyword(s):

Acute Lung Injury ◽

Lung Injury ◽

Influenza A ◽

Influenza A H1n1

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Extreme Efficiency of Airway Pressure Release Ventilation (APRV) in a Patient Suffering from Acute Lung Injury with Pandemic Influenza A (H1N1) 2009 and High Cytokines

The Indian Journal of Pediatrics ◽

10.1007/s12098-010-0280-1 ◽

2010 ◽

Vol 78 (3) ◽

pp. 348-350 ◽

Cited By ~ 2

Author(s):

Hisashi Kawashima ◽

Souken Go ◽

Shonosuke Nara ◽

Taro Miura ◽

Masataka Ushio ◽

...

Keyword(s):

Acute Lung Injury ◽

Lung Injury ◽

Pandemic Influenza ◽

Airway Pressure ◽

Influenza A ◽

Airway Pressure Release Ventilation ◽

Pressure Release ◽

Influenza A H1n1 ◽

Pressure Release Ventilation

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The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF-κB Pathway in Mice

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2015/790739 ◽

2015 ◽

Vol 2015 ◽

pp. 1-12 ◽

Cited By ~ 1

Author(s):

Lijuan Chen ◽

Xin Yan ◽

Qianlin Yan ◽

Jiajun Fan ◽

Hai Huang ◽

...

Keyword(s):

Influenza Virus ◽

Lung Injury ◽

Influenza A ◽

H1n1 Virus ◽

Alternative Therapy ◽

Severe Pneumonia ◽

H1n1 Influenza ◽

Influenza A H1n1 ◽

Lung Injuries ◽

Severe Lung

A new approach to treat infections of highly pathogenic influenza virus is to inhibit excessive innate immune response. JiuWei QiangHuo decoction has been used for centuries for the treatment of pulmonary disorders in China. In this study, we evaluated the anti-inflammatory activities of the modified JiuWei QiangHuo (MJWQH) decoction in the treatment of influenza A (H1N1) virus-induced severe pneumonia in mice. The results showed that MJWQH significantly increased the survival rate of H1N1-infected mice and suppressed the production of TNF-α, IL-1, IL-6, MCP-1, RANTES, and IFN-αon day 4 after infection. Moreover, oral administration of MJWQH efficiently inhibited virus replication and alleviated the severity of lung injuries. The results also showed that MJWQH may have potential therapeutic effect on severe lung injury induced by H1N1 virus by regulating the NF-κB pathway. Our study suggested that MJWQH might be an alternative therapy for the treatment of viral pneumonia.

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Activation of A1-Adenosine Receptors Promotes Leukocyte Recruitment to the Lung and Attenuates Acute Lung Injury in Mice Infected with Influenza A/WSN/33 (H1N1) Virus

Journal of Virology ◽

10.1128/jvi.01068-14 ◽

2014 ◽

Vol 88 (17) ◽

pp. 10214-10227 ◽

Cited By ~ 29

Author(s):

F. Aeffner ◽

P. S. Woods ◽

I. C. Davis

Keyword(s):

Acute Lung Injury ◽

Lung Injury ◽

Adenosine Receptors ◽

Influenza A ◽

H1n1 Virus ◽

Leukocyte Recruitment ◽

A1 Adenosine Receptors

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The effect of aminoguanidine on acute lung injury induced by influenza A/H1N1/PDM09

Medical academic journal ◽

10.17816/maj34094 ◽

2020 ◽

Vol 20 (2) ◽

pp. 33-44

Author(s):

Andrei G. Aleksandrov ◽

Tatiana N. Savateeva-Lyubimova ◽

Kira I. Stosman ◽

Arman A. Muzhikyan ◽

Konstantin V. Sivak

Keyword(s):

Influenza Virus ◽

Acute Lung Injury ◽

Lung Injury ◽

Influenza A ◽

Structural Changes ◽

Saturation Index ◽

Influenza Infection ◽

Proinflammatory Response ◽

Influenza Virus A ◽

Influenza A H1n1

Background. Acute lung injury is one of severe course of influenza infection with mortality up to 40% of patients, despite on etiological and pathogenetic therapy. The aim of the article to study of the effects of aminoguanidine on correcting on acute lung injury induced by influenza virus A/California/7/09MA (mouse-adapted) (H1N1)pdm09, collection Smorodintsev Research Institute of Influenza. Materials and methods. The study was performed on 95 outbred female mice. The mouse-adapted pandemic influenza virus A/California/7/09MA (H1N1)pdm09 was used for modeling viral infection at a dose of 1 LD50. The mortality was analysed. Levels of advanced glycation end-products (AGEs), proinflammatory cytokines in lung; saturation index and leukocytes marker parameters in blood; pathological and histological studies of lung were performed on 4 and 7 days post infection. Results. Aminoguanidine led to 2-fold decrease in mortality in mice with virus-induced acute lung injury; significantly suppressed the growth of AGEs and proinflammatory cytokine levels in lung; reduced decrease of saturation index and hematological inflammatory markers; decreased level of inflammatory injury in lung tissue. Conclusion. Aminoguanidine relieved virus-induced acute lung injury in mice. These AGEs inhibitor reduced the proinflammatory response and structural changes in respiratory tract epithelial cells induced by reactive carbonyl compounds on cell membrane.

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