Long-term glucocorticoid concentrations as a risk factor for childhood obesity and adverse body-fat distribution

2016 ◽  
Vol 40 (10) ◽  
pp. 1503-1509 ◽  
Author(s):  
G Noppe ◽  
E L T van den Akker ◽  
Y B de Rijke ◽  
J W Koper ◽  
V W Jaddoe ◽  
...  
Keyword(s):  
Risk Factor ◽  
Childhood Obesity ◽  
Body Fat ◽  
Fat Distribution ◽  
Body Fat Distribution

scholarly journals Long-term glucocorticoid concentrations as a risk factor for childhood obesity and adverse body fat distribution

2015 ◽  
Author(s):  
Gerard Noppe ◽  
den Akker Erica L T van ◽  
Rijke Yolanda B de ◽  
Jan W Koper ◽  
Vincent W Jaddoe ◽  
...  
Keyword(s):  
Risk Factor ◽  
Childhood Obesity ◽  
Body Fat ◽  
Fat Distribution ◽  
Body Fat Distribution

scholarly journals Unacylated ghrelin is associated with changes in body composition and body fat distribution during long-term exercise intervention

2011 ◽  
Vol 165 (2) ◽  
pp. 243-248 ◽  
Author(s):  
Henna Cederberg ◽  
Ulla Rajala ◽  
Vesa-Matti Koivisto ◽  
Jari Jokelainen ◽  
Heljä-Marja Surcel ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Composition ◽  
Waist Circumference ◽  
Body Fat ◽  
Exercise Performance ◽  
Exercise Intervention ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Unacylated Ghrelin

ObjectiveGhrelin, a gut–brain peptide involved in energy homeostasis, circulates predominantly (>90%) in unacylated form. Previous studies, however, have focused on total and acylated ghrelin, and the role of unacylated ghrelin (UAG) is not well understood. Particularly, the association of UAG with weight loss and changes in body composition in adults remains unclear. We hypothesized that exercise-associated increase in UAG level is associated with weight loss, favorable changes in body composition, and body fat distribution.Design and methodsA prospective study of 552 young men (mean age 19.3 and range 19–28 years) undergoing military service with structured 6-month exercise training program. Exercise performance, body composition, and biochemical measurements were obtained at baseline and follow-up. Association between changes in UAG levels and body composition and body fat distribution were evaluated.ResultsAn increase in UAG level during the exercise intervention was associated with reduced weight, fat mass (FM), fat percentage (fat %), and waist circumference, but not with fat-free mass. Inverse associations of changes in UAG level with changes in waist circumference and fat % were independent of weight at baseline, and changes in weight and exercise performance. Associations of changes in UAG level with waist circumference were significantly stronger than with fat % after the adjustment for confounding variables.ConclusionUAG is associated with changes in body weight and body composition during an intensive long-term exercise intervention in young men. The association of UAG levels with changes in central obesity was stronger than with total FM.

Altered body fat distribution in patients with glucocorticoid treatment and in patients on long-term dialysis

1986 ◽  
Vol 43 (5) ◽  
pp. 758-769 ◽  
Author(s):  
F F Horber ◽  
R M Zürcher ◽  
H Herren ◽  
M A C Crivelli ◽  
G Robotti ◽  
...  
Keyword(s):  
Body Fat ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Glucocorticoid Treatment

Body Fat Distribution as a Risk Factor of Endometrial Cancer

2000 ◽  
Vol 26 (6) ◽  
pp. 421-425 ◽  
Author(s):  
Akiko Iemura ◽  
Tsutomu Douchi ◽  
Shinako Yamamoto ◽  
Nobuyuki Yoshimitsu ◽  
Yukihiro Nagata
Keyword(s):  
Endometrial Cancer ◽  
Risk Factor ◽  
Body Fat ◽  
Fat Distribution ◽  
Body Fat Distribution

scholarly journals Impact of body fat distribution on long-term clinical outcomes after drug-eluting stent implantation

PLoS ONE ◽  
2018 ◽  
Vol 13 (5) ◽  
pp. e0197991 ◽  
Author(s):  
Se-Jun Park ◽  
Hong-Seok Lim ◽  
Seung-Soo Sheen ◽  
Hyoung-Mo Yang ◽  
Kyoung-Woo Seo ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Body Fat ◽  
Stent Implantation ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Drug Eluting Stent ◽  
Drug Eluting

scholarly journals Elucidating Under-Studied Aspects of the Link Between Obesity and Multiple Myeloma: Weight Pattern, Body Shape Trajectory, and Body Fat Distribution

2019 ◽  
Vol 3 (3) ◽  
Author(s):  
Catherine R Marinac ◽  
Catherine A Suppan ◽  
Edward Giovannucci ◽  
Mingyang Song ◽  
Ane S Kværner ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Weight Loss ◽  
Risk Factor ◽  
Body Fat ◽  
Body Shape ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Health Study ◽  
Medium Increase

Abstract Background Although obesity is an established modifiable risk factor for multiple myeloma (MM), several nuanced aspects of its relation to MM remain unelucidated, limiting public health and prevention messages. Methods We analyzed prospective data from the Nurses’ Health Study and Health Professionals Follow-Up Study to examine MM risk associated with 20-year weight patterns in adulthood, body shape trajectory from ages 5 to 60 years, and body fat distribution. For each aforementioned risk factor, we report hazard ratios (HRs) and 95% confidence intervals (CIs) for incident MM from multivariable Cox proportional-hazards models. Results We documented 582 incident MM cases during 4 280 712 person-years of follow-up. Persons who exhibited extreme weight cycling, for example, those with net weight gain and one or more episodes of intentional loss of at least 20 pounds or whose cumulative intentional weight loss exceeded net weight loss with at least one episode of intentional loss of 20 pounds or more had an increased MM risk compared with individuals who maintained their weight (HR = 1.71, 95% CI = 1.05 to 2.80); the association was statistically nonsignificant after adjustment for body mass index. We identified four body shape trajectories: lean-stable, lean-increase, medium-stable, and medium-increase. MM risk was higher in the medium-increase group than in the lean-stable group (HR = 1.62, 95% CI = 1.22 to 2.14). Additionally, MM risk increased with increasing hip circumference (HR per 1-inch increase: 1.03, 95% CI = 1.01 to 1.06) but was not associated with other body fat distribution measures. Conclusions Maintaining a lean and stable weight throughout life may provide the strongest benefit in terms of MM prevention.

scholarly journals Sex Differences in the Metabolic Syndrome: Implications for Cardiovascular Health in Women

2014 ◽  
Vol 60 (1) ◽  
pp. 44-52 ◽  
Author(s):  
Aruna D Pradhan
Keyword(s):  
Metabolic Syndrome ◽  
Sex Differences ◽  
Risk Factor ◽  
Body Fat ◽  
Hormonal Regulation ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Significant Heterogeneity ◽  
Clinical Expression ◽  
The Metabolic Syndrome

Abstract BACKGROUND The metabolic syndrome is a clinical condition characterized by the presence of multiple interrelated risk factors for type 2 diabetes and cardiovascular disease. Component features include dysglycemia, increased blood pressure, increased triglycerides, decreased HDL cholesterol concentrations, and obesity (in particular, abdominal obesity). The underlying biology, optimal diagnostic criteria, and clinical implications, once diagnosed, have been matter for intense debate. Despite these areas of controversy, there is now general consensus that the observed risk factor clustering signifies heightened cardiovascular risk. CONTENT The influence of sex on the clinical expression and pathophysiology of the syndrome is underrecognized, and is an issue of increasing importance given the alarming increase in prevalence among young women. This minireview will highlight sex differences in the epidemiology, etiology, biology, and clinical expression of the metabolic syndrome. In particular, key sex differences include distinctions in (a) prevalence of dysglycemia, (b) body fat distribution, (c) adipocyte size and function, (d) hormonal regulation of body weight and adiposity, and (e) the influence of estrogen decline on risk factor clustering. SUMMARY Accumulated and emerging data convincingly demonstrate that significant heterogeneity exists between men and women developing the metabolic syndrome, in large part related to hormonal regulation of body fat distribution and attendant metabolic abnormalities.

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