Lower extremity lymphatic function predicted by body mass index: a lymphoscintigraphic study of obesity and lipedema

Author(s):  
Arin K. Greene ◽  
Christopher L. Sudduth
2016 ◽  
Vol 41 (2) ◽  
pp. 186-193 ◽  
Author(s):  
Alexandra P Frost ◽  
Tracy Norman Giest ◽  
Allison A Ruta ◽  
Teresa K Snow ◽  
Mindy Millard-Stafford

Background: Body composition is important for health screening, but appropriate methods for unilateral lower extremity amputees have not been validated. Objectives: To compare body mass index adjusted using Amputee Coalition equations (body mass index–Amputee Coalition) to dual-energy X-ray absorptiometry in unilateral lower limb amputees. Study design: Cross-sectional, experimental. Methods: Thirty-eight men and women with lower limb amputations (transfemoral, transtibial, hip disarticulation, Symes) participated. Body mass index (mass/height2) was compared to body mass index corrected for limb loss (body mass index–Amputee Coalition). Accuracy of classification and extrapolation of percent body fat with body mass index was compared to dual-energy X-ray absorptiometry. Results: Body mass index–Amputee Coalition increased body mass index (by ~ 1.1 kg/m2) but underestimated and mis-classified 60% of obese and overestimated 100% of lean individuals according to dual-energy X-ray absorptiometry. Estimated mean percent body fat (95% confidence interval) from body mass index–Amputee Coalition (28.3% (24.9%, 31.7%)) was similar to dual-energy X-ray absorptiometry percent body fat (29.5% (25.2%, 33.7%)) but both were significantly higher ( p < 0.05) than percent body fat estimated from uncorrected body mass index (23.6% (20.4%, 26.8%)). However, total errors for body mass index and body mass index–Amputee Coalition converted to percent body fat were unacceptably large (standard error of the estimate = 6.8%, 6.2% body fat) and the discrepancy between both methods and dual-energy X-ray absorptiometry was inversely related ( r = −0.59 and r = −0.66, p < 0.05) to the individual’s level of body fatness. Conclusions: Body mass index (despite correction) underestimates health risk for obese patients and overestimates lean, muscular individuals with lower limb amputation. Clinical relevance Clinical recommendations for an ideal body mass based on body mass index–Amputee Coalition should not be relied upon in lower extremity amputees. This is of particular concern for obese lower extremity amputees whose health risk might be significantly underestimated based on body mass index despite a “correction” formula for limb loss.


2018 ◽  
Vol 15 (2) ◽  
pp. 127-134 ◽  
Author(s):  
Nathaniel S. Nye ◽  
Drew S. Kafer ◽  
Cara Olsen ◽  
David H. Carnahan ◽  
Paul F. Crawford

2015 ◽  
Vol 29 (6) ◽  
pp. 1136-1140 ◽  
Author(s):  
Anahita Dua ◽  
Sapan S. Desai ◽  
Alexander Nodel ◽  
Jennifer A. Heller

2012 ◽  
Vol 35 (15) ◽  
pp. 1269-1275 ◽  
Author(s):  
Dori E. Rosenberg ◽  
Aaron P. Turner ◽  
Alyson J. Littman ◽  
Rhonda M. Williams ◽  
Dan C. Norvell ◽  
...  

2009 ◽  
Vol 89 (1) ◽  
pp. 73-81 ◽  
Author(s):  
Patricia Kluding ◽  
Byron Gajewski

BackgroundBody system impairments following stroke have a complex relationship with functional activities. Although gait and balance deficits are well-documented in people after stroke, the overlapping influence of body impairments makes it difficult to prioritize interventions.ObjectiveThis study examined the relationship between prospectively selected measures of body function and structure (body mass index, muscle strength, sensation, and cognition) and activity (gait speed, gait endurance, and functional balance) in people with chronic stroke.DesignThis was a cross-sectional, observational study.MethodsTwenty-six individuals with mean (SD) age of 57.6 (11) years and time after stroke of 45.4 (43) months participated. Four variables (body mass index, muscle strength difference between the lower extremities, sensation difference between the lower extremities, and Mini-Mental Status Exam score) were entered into linear regression models for gait speed, Six-Minute Walk Test distance, and Berg Balance Scale score.ResultsLower-extremity strength difference was a significant individual predictor for gait speed, gait endurance, and functional balance. Cognition significantly predicted only gait speed.LimitationsThe authors did not include all possible factors in the model that may have influenced gait and balance in these individuals.ConclusionsStrength deficits in the hemiparetic lower extremity should be an important target for clinical interventions to improve function in people with chronic stroke.


2008 ◽  
Vol 89 (10) ◽  
pp. 2031-2033 ◽  
Author(s):  
Michelle Miller ◽  
Wing Ki Wong ◽  
Jing Wu ◽  
Sally Cavenett ◽  
Lynne Daniels ◽  
...  

Author(s):  
Francisco Félix Caballero ◽  
Ellen A Struijk ◽  
Antonio Buño ◽  
Fernando Rodríguez-Artalejo ◽  
Esther Lopez-Garcia

Abstract Background Higher levels of ceramides have been linked to several chronic diseases; also there is emerging cross-sectional evidence that ceramides are associated with lower physical functioning. This research assessed for the first time the prospective relationship between ceramide species and impaired lower-extremity function (ILEF) in older adults. Methods Case–control study with 43 cases of ILEF and 86 age- and sex-matched controls, which was nested in the Seniors-ENRICA cohort of community-dwelling older adults. Incident ILEF from 2015 to 2017 was ascertained with the Short Physical Performance Battery. In 2015, 27 ceramide species were measured in plasma by liquid chromatography-tandem mass spectrometry. Conditional logistic regression models were used to assess the longitudinal relationship between ceramides concentration and incidence of ILEF. Results After adjusting for education level, body mass index, alcohol and total energy intake, physical activity, and presence of chronic conditions, some ceramide species were related to 2-year incidence of ILEF. Specifically, the odds ratios of ILEF per 1-SD increase in ceramide concentration were: 1.66 [95% CI = (1.03, 2.68)] for ceramide C14:0, 1.61 (1.00, 2.59) for ceramide C16:0, and 1.64 (1.03, 2.60) for ceramide C16:1 (n-7). In the case of ceramides C16:0 and C16:1 (n-7), a stronger relationship was found in those with a higher body mass index; systolic blood pressure could also mediate the relationship between ceramide C16:1 (n-7) and ILEF (p for interaction = .03). Conclusions Higher plasma levels of ceramides C14:0, C16:0, and C16:1 (n-7) are associated with higher risk of ILEF, and might serve as risk markers for functional decline in older adults.


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