scholarly journals Role of the medial prefrontal cortex in the effects of rapid acting antidepressants on decision-making biases in rodents

2020 ◽  
Vol 45 (13) ◽  
pp. 2278-2288 ◽  
Author(s):  
C. A. Hales ◽  
J. M. Bartlett ◽  
R. Arban ◽  
B. Hengerer ◽  
E. S. J. Robinson
Keyword(s):  
Decision Making ◽  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Decision Making Biases

scholarly journals Role of the medial prefrontal cortex in the effects of rapid acting antidepressants on decision-making biases in rodents

2020 ◽  
Author(s):  
CA Hales ◽  
JM Bartlett ◽  
R Arban ◽  
B Hengerer ◽  
ESJ Robinson
Keyword(s):  
Decision Making ◽  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Specific Effect ◽  
Nmda Antagonists ◽  
Neuropsychological Effects ◽  
Clinical Benefits ◽  
Subtype Selective ◽  
Decision Making Biases

AbstractMajor Depressive Disorder is a significant and costly cause of global disability. Until the discovery of the rapid acting antidepressant (RAAD) effects of ketamine, treatments were limited to drugs that have delayed clinical benefits. The mechanism of action of ketamine is currently unclear but one hypothesis is that it may involve neuropsychological effects mediated through modulation of affective biases (where cognitive processes such as learning and memory and decision-making are modified by emotional state). Previous work has shown that affective biases in a rodent decision-making task are differentially altered by ketamine, compared to conventional, delayed onset antidepressants. This study sought to further investigate these effects by comparing ketamine with other NMDA antagonists using this decision-making task. We also investigated the subtype selective GluN2B antagonist, CP-101,606 and muscarinic antagonist scopolamine which have both been shown to have RAAD effects. Both CP-101,606 and scopolamine induced similar positive biases in decision-making to ketamine, but the same effects were not seen with other NMDA antagonists. Using targeted medial prefrontal cortex (mPFC) infusions, these effects were localised to the mPFC. In contrast, the GABAA agonist, muscimol, induced general disruptions to behaviour. These data suggest that ketamine and other RAADs mediate a specific effect on affective bias which involves the mPFC. Non-ketamine NMDA antagonists lacked efficacy and we also found that temporary inactivation of the mPFC did not fully recapitulate the effects of ketamine, suggesting a specific mechanism.

scholarly journals Role of the Medial Prefrontal Cortex in Impaired Decision Making in Juvenile Attention-Deficit/Hyperactivity Disorder

2014 ◽  
Vol 71 (10) ◽  
pp. 1165 ◽  
Author(s):  
Tobias U. Hauser ◽  
Reto Iannaccone ◽  
Juliane Ball ◽  
Christoph Mathys ◽  
Daniel Brandeis ◽  
...  
Keyword(s):  
Decision Making ◽  
Attention Deficit Hyperactivity Disorder ◽  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Attention Deficit ◽  
Hyperactivity Disorder

scholarly journals The Role of Medial Prefrontal Cortex in Memory and Decision Making

Neuron ◽  
2012 ◽  
Vol 76 (6) ◽  
pp. 1057-1070 ◽  
Author(s):  
David R. Euston ◽  
Aaron J. Gruber ◽  
Bruce L. McNaughton
Keyword(s):  
Decision Making ◽  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex
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