The Multiple Sclerosis Intimacy and Sexuality Questionnaire (MSISQ-15): validation of the Italian version for individuals with spinal cord injury

✓ A total of 93 patients with intractable spasticity due to either spinal cord injury (59 cases), multiple sclerosis (31 cases), or other spinal pathology (three cases) were entered into a randomized double-blind placebocontrolled screening protocol of intrathecal baclofen test injections. Of the 88 patients who responded to an intrathecal bolus of 50, 75, or 100 µg of baclofen, 75 underwent implantation of a programmable pump system for chronic therapy. Patients were followed for 5 to 41 months after surgery (mean 19 months). No deaths or new permanent neurological deficits occurred as a result of surgery or chronic intrathecal baclofen administration. Rigidity was reduced from a mean preoperative Ashworth scale score of 3.9 to a mean postoperative score of 1.7. Muscle spasms were reduced from a mean preoperative score of 3.1 (on a fourpoint scale) to a mean postoperative score of 1.0. Although the dose of intrathecal baclofen required to control spasticity increased with time, drug tolerance was not a limiting factor in this study. Only one patient withdrew from the study because of a late surgical complication (pump pocket infection). Another patient received an intrathecal baclofen overdose because of a human error in programming the pump. The results of this study indicate that intrathecal baclofen infusion can be safe and effective for the long-term treatment of intractable spasticity in patients with spinal cord injury or multiple sclerosis.

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Acrolein detection: potential theranostic utility in multiple sclerosis and spinal cord injury

Expert Review of Neurotherapeutics ◽

10.1586/14737175.2014.918849 ◽

2014 ◽

Vol 14 (6) ◽

pp. 679-685 ◽

Cited By ~ 12

Author(s):

Melissa Tully ◽

Lingxing Zheng ◽

Riyi Shi

Keyword(s):

Multiple Sclerosis ◽

Spinal Cord ◽

Spinal Cord Injury ◽

Cord Injury

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Plasma membrane calcium ATPase deficiency causes neuronal pathology in the spinal cord: a potential mechanism for neurodegeneration in multiple sclerosis and spinal cord injury

The FASEB Journal ◽

10.1096/fj.04-2549fje ◽

2004 ◽

Vol 19 (2) ◽

pp. 1-19 ◽

Cited By ~ 77

Author(s):

Michael P. Kurnellas ◽

Arnaud Nicot ◽

Gary E. Shull ◽

Stella Elkabes

Keyword(s):

Multiple Sclerosis ◽

Spinal Cord ◽

Spinal Cord Injury ◽

Plasma Membrane ◽

Calcium Atpase ◽

Potential Mechanism ◽

Plasma Membrane Calcium Atpase ◽

Cord Injury ◽

Neuronal Pathology

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Brief Course of Ultra-High Dose IV Methylprednisolone in the Treatment of Multiple Sclerosis Exacerbations

10.47363/jnrrr/2020(2)114 ◽

2020 ◽

pp. 1-4

Author(s):

Robert Knobler ◽

Keyword(s):

Multiple Sclerosis ◽

Spinal Cord ◽

Spinal Cord Injury ◽

High Dose ◽

Side Effect Profile ◽

Intravenous Methylprednisolone ◽

The Past ◽

Disease Modifying Therapies ◽

Cord Injury ◽

Disease Modifying

Despite the introduction of a number of effective disease modifying therapies (DMT) for multiple sclerosis (MS) over the past 25 years, a need remains for an effective method of treating breakthrough relapses, which impact disease progression. ACTH and corticosteroids have fulfilled this role for the past 50 years. However, based upon our current understanding of the cadence of an exacerbation, and its importance in the progression of MS, an alternative is proposed. This utilizes a very brief course of an ultra-high dose of intravenous methylprednisolone, adapted from the megadose protocol of methylprednisolone in acute spinal cord injury. Despite the known side effect profile of corticosteroids, and the ultra-high dose employed, the brevity in administration yields a well-tolerated, rapid resolution of the relapse

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Neuro-pharmacologic control of bladder voiding. Pharmacologic therapy of detrusor-sphincter dyssynergia concerning 162 patients

Urologia Journal ◽

10.1177/039156039205900415 ◽

1992 ◽

Vol 59 (4) ◽

pp. 56-62

Author(s):

G. Ronzoni ◽

M. De Vecchis ◽

R. Raschi ◽

G. Nucci ◽

L. De Giovanni ◽

...

Keyword(s):

Multiple Sclerosis ◽

Spinal Cord ◽

Spinal Cord Injury ◽

Pharmacologic Therapy ◽

Detrusor Sphincter Dyssynergia ◽

Cord Injury

The Authors refer to current opinions regarding the neuro-pharmacologic control of bladder voiding. They report their experience concerning 162 patients with detrusor-sphincter dyssynergia: 86 pts were affected by multiple sclerosis and 76 by neurobladder after spinal cord injury.

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Long-term neurological conditions

Oxford Handbook of Neuroscience Nursing ◽

10.1093/med/9780198831570.003.0008 ◽

2020 ◽

pp. 175-278

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Spinal Cord ◽

Spinal Cord Injury ◽

Sudden Onset ◽

Motor Neurone ◽

Cord Injury ◽

Neurological Conditions

There are several hundred neurological conditions, some more commonly occurring than others. NHS England categorizes them into sudden-onset conditions resulting from an acquired or traumatic brain or spinal cord injury; progressive deteriorating conditions such as Alzheimer’s disease, dementia, and motor neurone disease; and other conditions that might have a more fluctuating pathway such as epilepsy, Parkinson’s disease, or multiple sclerosis. Most of these conditions result in varying degrees of disability that demand considerable personal and NHS resources to improve independence and the quality of life for these people.

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