scholarly journals Implantation of Neuropixels probes for chronic recording of neuronal activity in freely behaving mice and rats

2021 ◽  
Author(s):  
Rik J. J. van Daal ◽  
Çağatay Aydin ◽  
Frédéric Michon ◽  
Arno A. A. Aarts ◽  
Michael Kraft ◽  
...  
Keyword(s):  
Neuronal Activity ◽  
Chronic Recording ◽  
Freely Behaving

scholarly journals Global sleep homeostasis reflects temporally and spatially integrated local cortical neuronal activity

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Christopher W Thomas ◽  
Mathilde CC Guillaumin ◽  
Laura E McKillop ◽  
Peter Achermann ◽  
Vladyslav V Vyazovskiy
Keyword(s):  
Neuronal Activity ◽  
Wave Activity ◽  
Neuronal Firing ◽  
Daily Amount ◽  
Local Process ◽  
Sleep Homeostasis ◽  
Freely Behaving ◽  
Electroencephalogram Eeg ◽  
Activity Dependent ◽  
Wake State

Sleep homeostasis manifests as a relative constancy of its daily amount and intensity. Theoretical descriptions define ‘Process S’, a variable with dynamics dependent on global sleep-wake history, and reflected in electroencephalogram (EEG) slow wave activity (SWA, 0.5–4 Hz) during sleep. The notion of sleep as a local, activity-dependent process suggests that activity history must be integrated to determine the dynamics of global Process S. Here, we developed novel mathematical models of Process S based on cortical activity recorded in freely behaving mice, describing local Process S as a function of the deviation of neuronal firing rates from a locally defined set-point, independent of global sleep-wake state. Averaging locally derived Processes S and their rate parameters yielded values resembling those obtained from EEG SWA and global vigilance states. We conclude that local Process S dynamics reflects neuronal activity integrated over time, and global Process S reflects local processes integrated over space.

Automated imaging of neuronal activity in freely behaving Caenorhabditis elegans

2010 ◽  
Vol 187 (2) ◽  
pp. 229-234 ◽  
Author(s):  
Juliette Ben Arous ◽  
Yoshinori Tanizawa ◽  
Ithai Rabinowitch ◽  
Didier Chatenay ◽  
William R. Schafer
Keyword(s):  
Caenorhabditis Elegans ◽  
Neuronal Activity ◽  
Automated Imaging ◽  
Freely Behaving

scholarly journals Large-Scale Chronically Implantable Precision Motorized Microdrive Array for Freely Behaving Animals

2008 ◽  
Vol 100 (4) ◽  
pp. 2430-2440 ◽  
Author(s):  
Jun Yamamoto ◽  
Matthew A. Wilson
Keyword(s):  
Single Unit ◽  
Large Scale ◽  
Neural Circuits ◽  
Brain Regions ◽  
Unit Recording ◽  
Chronic Recording ◽  
Large Numbers ◽  
Freely Behaving

Multiple single-unit recording has become one of the most powerful in vivo electro-physiological techniques for studying neural circuits. The demand has been increasing for small and lightweight chronic recording devices that allow fine adjustments to be made over large numbers of electrodes across multiple brain regions. To achieve this, we developed precision motorized microdrive arrays that use a novel motor multiplexing headstage to dramatically reduce wiring while preserving precision of the microdrive control. Versions of the microdrive array were chronically implanted on both rats (21 microdrives) and mice (7 microdrives), and relatively long-term recordings were taken.

scholarly journals Applications of a novel radiotelemetry method for the measurement of intrathoracic pressures and physiological rhythms in freely behaving mice

2020 ◽  
Vol 129 (4) ◽  
pp. 992-1005
Author(s):  
Andrew J. Foster ◽  
Jade P. Marrow ◽  
Melissa A. Allwood ◽  
Keith R. Brunt ◽  
Jeremy A. Simpson
Keyword(s):  
Heart Rate ◽  
Circadian Rhythm ◽  
Body Temperature ◽  
Respiratory Function ◽  
Intrathoracic Pressure ◽  
Hypoxic Stress ◽  
Chronic Recording ◽  
Respiratory Parameters ◽  
Freely Behaving ◽  
First Time

We have demonstrated for the first time in mice that radiotelemetry is an effective tool for the continuous and chronic recording of intrathoracic pressure (ITP) to facilitate circadian rhythm analyses. We show that continuous 24-h hypoxic stress alters the circadian rhythms of heart rate, body temperature, activity, and respiratory parameters, acutely and perpetually, through normoxic recovery. Radiotelemetry of ITP can complement traditional methods for evaluating respiratory function and better our understanding of respiratory pathophysiology.

scholarly journals Targeted manipulation of neuronal activity in behaving adult flies

2016 ◽  
Author(s):  
Stefanie Hampel ◽  
Andrew Michael Seeds
Keyword(s):  
Drosophila Melanogaster ◽  
Neuronal Activity ◽  
Neural Circuits ◽  
Neural Circuit ◽  
Fruit Fly ◽  
Specific Behavior ◽  
Freely Behaving ◽  
The Rich ◽  
Circuit Function

The ability to control the activity of specific neurons in freely behaving animals provides an effective way to probe the contributions of neural circuits to behavior. Wide interest in studying principles of neural circuit function using the fruit fly Drosophila melanogaster has fueled the construction of an extensive transgenic toolkit for performing such neural manipulations. Here we describe approaches for using these tools to manipulate the activity of specific neurons and assess how those manipulations impact the behavior of flies. We also describe methods for examining connectivity among multiple neurons that together form a neural circuit controlling a specific behavior. This work provides a resource for researchers interested in examining how neurons and neural circuits contribute to the rich repertoire of behaviors performed by flies.

scholarly journals Zolpidem Reduces Hippocampal Neuronal Activity in Freely Behaving Mice: A Large Scale Calcium Imaging Study with Miniaturized Fluorescence Microscope

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e112068 ◽  
Author(s):  
Tamara Berdyyeva ◽  
Stephani Otte ◽  
Leah Aluisio ◽  
Yaniv Ziv ◽  
Laurie D. Burns ◽  
...  
Keyword(s):  
Neuronal Activity ◽  
Calcium Imaging ◽  
Large Scale ◽  
Imaging Study ◽  
Fluorescence Microscope ◽  
Freely Behaving
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