scholarly journals Impact of elevated blood pressure on mortality from all causes, cardiovascular diseases, heart disease and stroke among Japanese: 14 year follow-up of randomly selected population from Japanese — Nippon data 80

2003 ◽  
Vol 17 (12) ◽  
pp. 851-857 ◽  
Author(s):  
Keyword(s):  
Blood Pressure ◽  
Heart Disease ◽  
Cardiovascular Diseases ◽  
Elevated Blood Pressure ◽  
Elevated Blood

Cross-talk between ANGPTL4 gene SNP rs1044250 and weight management is a risk factor of Mets

2020 ◽  
Author(s):  
Zhoujie Tong ◽  
Jie Peng ◽  
Hongtao Lan ◽  
Wenwen Sai ◽  
Yulin Li ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Risk Factor ◽  
Waist Circumference ◽  
Weight Management ◽  
Independent Risk Factor ◽  
Lifestyle Changes ◽  
Elevated Blood Pressure ◽  
Base Line ◽  
Elevated Blood

Abstract Background The prevalence of metabolic syndrome (Mets) is closely related to the increased incidence of cardiovascular events. Angiopoietin-like protein 4 (ANGPTL4) is contributory to the regulation of lipid metabolism, herein, may provide a target for gene-aimed therapy of Mets. This case-control study was designed to elucidate the relationship between Angiopoietin-like protein 4 (ANGPTL4) gene single nucleotide polymorphism (SNP) rs1044250 and the onset of Mets, and to explore the effect of interaction between SNP rs1044250 and weight management on Mets. Methods We have recruited 1018 Mets cases and 1029 controls in this study. The SNP rs1044250 was detected, base-line information and Mets-related indicators were collected. A 5-year follow-up survey was carried out to track the lifestyle changes, drug treatments and changes in Mets-related indicators. Results ANGPTL4 gene SNP rs1044250 is an independent risk factor for increased waist circumference (OR 1.618, 95% CI [1.119–2.340]; p = 0.011) and elevated blood pressure (OR 1.323, 95% CI [1.002–1.747]; p = 0.048), the prevalence of Mets (OR 1.875, 95% CI [1.363–2.580]; p < 0.001) is increased. The follow-up survey shows that rs1044250 CC genotype patients with weight gain have an increased number of Mets components (M [Q1, Q3]: CC 1 (0, 1), CT + TT 0 [-1, 1]; p = 0.021); The interaction between SNP rs1044250 and weight management is a risk factor for increased SBP (β = 0.075, p < 0.001) and increased DBP (β = 0.097, p < 0.001), the synergistic effect is negative (S < 1). Conclusion ANGPTL4 gene SNP rs1044250 is an independent risk factor for increased waist circumference and elevated blood pressure, therefore, for Mets. Weight management that interacts negatively with ANGPTL4 polymorphism is an essential lifestyle intervention approach for elevated blood pressure.

A Computer-Based Monitoring System for Follow-Up of Elevated Blood Pressure

Medical Care ◽  
1983 ◽  
Vol 21 (4) ◽  
pp. 400-409 ◽  
Author(s):  
G Octo Barnett ◽  
Richard N. Winickoff ◽  
Mary M. Morgan ◽  
Rita D. Zielstorff
Keyword(s):  
Blood Pressure ◽  
Monitoring System ◽  
Elevated Blood Pressure ◽  
Elevated Blood ◽  
Computer Based

scholarly journals Facets of negative affectivity and blood pressure in middle-aged men

2013 ◽  
Vol 1 (2) ◽  
pp. 14 ◽  
Author(s):  
Cornel V. Igna ◽  
Juhani Julkunen ◽  
Jari Lipsanen ◽  
Hannu Vanhanen
Keyword(s):  
Blood Pressure ◽  
Risk Factor ◽  
Depressive Symptoms ◽  
Cardiovascular Diseases ◽  
Health Behavior ◽  
Negative Affectivity ◽  
Elevated Blood Pressure ◽  
Elevated Blood ◽  
Middle Aged ◽  
Vital Exhaustion

Research results suggesting that facets of negative affectivity, <em>i.e. </em>anxiety, anger-hostility, and depression, relate to incident cardiovascular diseases have been steadily increasing. Evidence for depression has been especially extensive. Elevated blood pressure, a major risk factor of cardiovascular diseases, is one probable mediator in this context. The purpose of this study was to clarify the relationship of specific key elements of depressive disposition, <em>i.e</em>. depressive symptoms, hopelessness and vital exhaustion, with health behavior and blood pressure. Study sample was comprised of 710 middle-aged men. Participants completed self-report questionnaires assessing health behavior, depressive symptoms, vital exhaustion and hopelessness. Statistical analyses involved descriptive analyses, correlations and path analysis. Depressive symptoms and vital exhaustion associated with several unfavorable lifestyles such as smoking, alcohol consumption, and inactivity (standardized solution coefficients: 0.10, 0.14, 0.17, accordingly). However, no significant direct associations with blood pressure could be found for depressive symptoms or vital exhaustion. Hopelessness associated only with unhealthy diet (standardized solution coefficient -0.10) Moreover, for hopelessness, results showed a direct but inverse association with systolic blood pressure (standardized solution coefficient -0.08). Results suggest that the previously reported relations of depression and vital exhaustion with blood pressure could be mediated by unfavorable lifestyles. The relation of hopelessness with adverse health behaviors seems to be less significant. Also, the role of hopelessness as a risk factor of elevated blood pressure is not supported by the results of this study.

scholarly journals Antemortem Visit-To-Visit Blood Pressure Variability Predicts Cerebrovascular Lesion Burden in Autopsy-Confirmed Alzheimer’s Disease

2021 ◽  
pp. 1-11
Author(s):  
Isabel J. Sible ◽  
Katherine J. Bangen ◽  
Anna E. Blanken ◽  
Jean K. Ho ◽  
Daniel A. Nation
Keyword(s):  
Alzheimer’S Disease ◽  
Blood Pressure ◽  
Alzheimer's Disease ◽  
Cerebrovascular Disease ◽  
Blood Pressure Variability ◽  
Cognitive Change ◽  
Elevated Blood Pressure ◽  
Elevated Blood ◽  
Cerebrovascular Lesion

Background: Blood pressure variability is linked to Alzheimer’s disease (AD) risk and MRI-based markers of cerebrovascular disease. Less is known about the role of blood pressure variability in postmortem evaluation of cerebrovascular disease and AD. Objective: To determine whether antemortem blood pressure variability predicts cerebrovascular and AD pathology and follow-up cognitive change in autopsy-confirmed AD. Methods: National Alzheimer’s Coordinating Center participants (n = 513) underwent 3-4 approximately annual blood pressure measurements and were confirmed to have AD at postmortem evaluation. A subset (n = 493) underwent neuropsychological evaluation at follow-up. Regression models examined relationships between blood pressure variability and cerebrovascular and AD pathological features and follow-up cognitive change. Results: Elevated blood pressure variability predicted increased postmortem cerebrovascular lesion burden (ß = 0.26 [0.10, 0.42]; p = 0.001; R 2 = 0.12). Increased blood pressure variability predicted specific cerebrovascular lesion severity, including atherosclerosis in the Circle of Willis (OR = 1.22 [1.03, 1.44]; p = 0.02) and cerebral arteriolosclerosis (OR = 1.32 [1.04, 1.69]; p = 0.03). No significant relationships were observed between blood pressure variability and AD pathological findings, including Braak & Braak stage, neuritic plaques or diffuse plaques, or cerebral amyloid angiopathy, or follow-up cognitive decline. Conclusion: Findings suggest that elevated blood pressure variability is related to postmortem cerebrovascular lesion burden in autopsy-confirmed AD, independent of average blood pressure and AD neuropathology. Blood pressure fluctuation may selectively promote atherosclerotic and arteriolosclerotic brain lesions with potential implications for cognitive impairment and dementia.

Abstract 168: Routine Blood Pressure Screening in an Asymptomatic Pediatric Population

Hypertension ◽  
2013 ◽  
Vol 62 (suppl_1) ◽  
Author(s):  
David A Knorek ◽  
Qi Shi ◽  
Linda Thomas-Hemak ◽  
Carlos Acuna ◽  
Richard May
Keyword(s):  
Blood Pressure ◽  
Pediatric Population ◽  
Elevated Blood Pressure ◽  
Elevated Blood ◽  
Pediatric Hypertension ◽  
Asymptomatic Children ◽  
Blood Pressure Screening ◽  
Well Child Visit ◽  
Child Visit

Background Hypertension is on the rise in the pediatric population. Untreated hypertension is the basis for CV disease. The intent of this study is to encourage routine pediatric blood pressure screening. Methods A nine question phone survey of regional NE PA pediatricians, family physicians, and internists regarding the routing exam of asymptomatic children. Results 20 out of 31 (64.5%) respondents participated in this survey. 8 of the 11 (72.7%) contacts that did not participate were unable to be reached for reasons including incorrect contact information or failure to provide a callback, and the remaining 3 contacts rejected participation directly. The average age for annual blood pressure screening was 2.6 years old. All 20 participants (100%) follow blood pressure readings in asymptomatic children, and a majority of these respondents (85%) answered “yearly” follow-up for blood pressure in asymptomatic children. When asked whether parents accompany the well-child visit, 90% answered yes. Well-baby checks are stopped at a 50/50 split between 18 months and 24 months. When asked about how elevated blood pressure in a well-visit is followed in asymptomatic children, the responses varied. Responses included bringing back the patient within 48 hours for follow-up to 1-month follow-up, in addition to further testing for thyroid and kidney concerns. All 20 of the participants answered that BMI is monitored during the well-child visit, and 2.5 years of age was the average response to what age BMI monitoring begins. Conclusion Our data reflects the need to generate a greater understanding of how clinicians are screening asymptomatic pediatric populations, and then following up once an elevated blood pressure is recorded. It could be hypothesized as pediatric hypertension rates continue to rise there will be greater incidences of cardiovascular and neurovascular-related sequelae in adult populations as well.

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