scholarly journals Facets of negative affectivity and blood pressure in middle-aged men

2013 ◽  
Vol 1 (2) ◽  
pp. 14 ◽  
Author(s):  
Cornel V. Igna ◽  
Juhani Julkunen ◽  
Jari Lipsanen ◽  
Hannu Vanhanen
Keyword(s):  
Blood Pressure ◽  
Risk Factor ◽  
Depressive Symptoms ◽  
Cardiovascular Diseases ◽  
Health Behavior ◽  
Negative Affectivity ◽  
Elevated Blood Pressure ◽  
Elevated Blood ◽  
Middle Aged ◽  
Vital Exhaustion

Research results suggesting that facets of negative affectivity, <em>i.e. </em>anxiety, anger-hostility, and depression, relate to incident cardiovascular diseases have been steadily increasing. Evidence for depression has been especially extensive. Elevated blood pressure, a major risk factor of cardiovascular diseases, is one probable mediator in this context. The purpose of this study was to clarify the relationship of specific key elements of depressive disposition, <em>i.e</em>. depressive symptoms, hopelessness and vital exhaustion, with health behavior and blood pressure. Study sample was comprised of 710 middle-aged men. Participants completed self-report questionnaires assessing health behavior, depressive symptoms, vital exhaustion and hopelessness. Statistical analyses involved descriptive analyses, correlations and path analysis. Depressive symptoms and vital exhaustion associated with several unfavorable lifestyles such as smoking, alcohol consumption, and inactivity (standardized solution coefficients: 0.10, 0.14, 0.17, accordingly). However, no significant direct associations with blood pressure could be found for depressive symptoms or vital exhaustion. Hopelessness associated only with unhealthy diet (standardized solution coefficient -0.10) Moreover, for hopelessness, results showed a direct but inverse association with systolic blood pressure (standardized solution coefficient -0.08). Results suggest that the previously reported relations of depression and vital exhaustion with blood pressure could be mediated by unfavorable lifestyles. The relation of hopelessness with adverse health behaviors seems to be less significant. Also, the role of hopelessness as a risk factor of elevated blood pressure is not supported by the results of this study.

Abstract P080: Lifetime Trauma Is Associated With Elevated Blood Pressure In Middle-aged And Older Latinas

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Danny Vo ◽  
Billy A Caceres
Keyword(s):  
Blood Pressure ◽  
Regression Models ◽  
Elevated Blood Pressure ◽  
Traumatic Experiences ◽  
Sociocultural Factors ◽  
Ptsd Symptoms ◽  
Elevated Blood ◽  
Latina Women ◽  
Middle Aged ◽  
Lifetime Trauma

Introduction: Latina women are more likely than non-Latina White women to have uncontrolled and undertreated hypertension. Prior research suggests greater exposure to traumatic experiences (such as interpersonal violence) is associated with elevated blood pressure and higher cardiovascular disease risk in women. However, few studies have investigated these associations among Latina women, a population that is at increased risk for hypertension. The purpose of this pilot study was to fill knowledge gaps by examining the associations of lifetime trauma (including childhood and adulthood) with blood pressure in middle-aged and older Latinas. Hypothesis: We assessed the hypothesis that lifetime trauma is associated with elevated blood pressure in middle-aged and older Latinas. Methods: Participants were recruited from an existing study in New York City called the Washington Heights/Inwood Comparative Effectiveness Research Project. Data collection consisted of a questionnaire administered by a research coordinator and in-office assessment of two blood pressure readings using recommended guidelines. The average systolic and diastolic blood pressures were calculated from these two measurements. Lifetime trauma was assessed with the Life Events Checklist which assesses 17 potentially traumatic experiences. We summed responses to the Life Events Checklist to create a count of lifetime trauma. Posttraumatic stress disorder (PTSD) symptoms were assessed with the PTSD Checklist-Civilian Version that assess presence and severity of 17 PTSD symptoms in the last month. We used linear regression models to separately examine the associations of lifetime trauma with systolic and diastolic blood pressure adjusted for demographic characteristics, health behaviors, PTSD symptoms, sociocultural factors (such as discrimination and acculturation). Results: The final sample included 50 Latina women (ages 42-77, mean=63.1 [9.7]). All women reported at least one traumatic experience with an average of 4.8 traumatic experiences in their lifetimes (range 1-10). A higher count of lifetime trauma (B [SE] = 5.56 [2.63], p = 0.04) was positively associated with greater systolic blood pressure in adjusted regression models. Although women who reported a higher count of lifetime trauma had higher diastolic blood pressure, this association was not statistically significant (B [SE] = 2.14 [1.67], p = 0.21). Conclusion: Findings indicate a higher count of lifetime trauma is associated with elevations in systolic blood pressure among Latina women. This is consistent with results of studies that have examined associations of lifetime trauma with blood pressure among women in the general population. There is a need for larger studies that incorporate longitudinal designs to investigate the associations of trauma and other sociocultural factors with blood pressure among Latina women.

Cross-talk between ANGPTL4 gene SNP rs1044250 and weight management is a risk factor of Mets

2020 ◽  
Author(s):  
Zhoujie Tong ◽  
Jie Peng ◽  
Hongtao Lan ◽  
Wenwen Sai ◽  
Yulin Li ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Risk Factor ◽  
Waist Circumference ◽  
Weight Management ◽  
Independent Risk Factor ◽  
Lifestyle Changes ◽  
Elevated Blood Pressure ◽  
Base Line ◽  
Elevated Blood

Abstract Background The prevalence of metabolic syndrome (Mets) is closely related to the increased incidence of cardiovascular events. Angiopoietin-like protein 4 (ANGPTL4) is contributory to the regulation of lipid metabolism, herein, may provide a target for gene-aimed therapy of Mets. This case-control study was designed to elucidate the relationship between Angiopoietin-like protein 4 (ANGPTL4) gene single nucleotide polymorphism (SNP) rs1044250 and the onset of Mets, and to explore the effect of interaction between SNP rs1044250 and weight management on Mets. Methods We have recruited 1018 Mets cases and 1029 controls in this study. The SNP rs1044250 was detected, base-line information and Mets-related indicators were collected. A 5-year follow-up survey was carried out to track the lifestyle changes, drug treatments and changes in Mets-related indicators. Results ANGPTL4 gene SNP rs1044250 is an independent risk factor for increased waist circumference (OR 1.618, 95% CI [1.119–2.340]; p = 0.011) and elevated blood pressure (OR 1.323, 95% CI [1.002–1.747]; p = 0.048), the prevalence of Mets (OR 1.875, 95% CI [1.363–2.580]; p < 0.001) is increased. The follow-up survey shows that rs1044250 CC genotype patients with weight gain have an increased number of Mets components (M [Q1, Q3]: CC 1 (0, 1), CT + TT 0 [-1, 1]; p = 0.021); The interaction between SNP rs1044250 and weight management is a risk factor for increased SBP (β = 0.075, p < 0.001) and increased DBP (β = 0.097, p < 0.001), the synergistic effect is negative (S < 1). Conclusion ANGPTL4 gene SNP rs1044250 is an independent risk factor for increased waist circumference and elevated blood pressure, therefore, for Mets. Weight management that interacts negatively with ANGPTL4 polymorphism is an essential lifestyle intervention approach for elevated blood pressure.

scholarly journals Optimal Blood Pressure Keeps Our Brains Younger

2021 ◽  
Vol 13 ◽  
Author(s):  
Nicolas Cherbuin ◽  
Erin I. Walsh ◽  
Marnie Shaw ◽  
Eileen Luders ◽  
Kaarin J. Anstey ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Risk Factor ◽  
Diastolic Blood Pressure ◽  
Premature Death ◽  
Progressive Increase ◽  
Elevated Blood Pressure ◽  
Elevated Blood ◽  
Brain Health ◽  
Optimal Blood Pressure ◽  
Blood Pressure Range

Background: Elevated blood pressure (BP) is a major health risk factor and the leading global cause of premature death. Hypertension is also a risk factor for cognitive decline and dementia. However, when elevated blood pressure starts impacting cerebral health is less clear. We addressed this gap by estimating how a validated measure of brain health relates to changes in BP over a period of 12 years.Methods: Middle-age (44–46 years at baseline, n = 335, 52% female) and older-age (60–64 years, n = 351, 46% female) cognitively intact individuals underwent up to four brain scans. Brain health was assessed using a machine learning approach to produce an estimate of “observed” age (BrainAGE), which can be contrasted with chronological age. Longitudinal associations between blood pressures and BrainAGE were assessed with linear mixed-effects models.Results: A progressive increase in BP was observed over the follow up (MAP = 0.8 mmHg/year, SD = 0.92; SBP = 1.41 mmHg/year, SD = 1.49; DBP = 0.61 mmHg/year, SD = 0.78). In fully adjusted models, every additional 10 mmHg increase in blood pressure (above 90 for mean, 114 for systolic, and 74 for diastolic blood pressure) was associated with a higher BrainAGE by 65.7 days for mean, and 51.1 days for systolic/diastolic blood pressure. These effects occurred across the blood pressure range and were not exclusively driven by hypertension.Conclusion: Increasing blood pressure is associated with poorer brain health. Compared to a person becoming hypertensive, somebody with an ideal BP is predicted to have a brain that appears more than 6 months younger at midlife.

scholarly journals Risk Factor of Elevated Blood Pressure Among Children in Tulikup Village, Bali

2021 ◽  
Vol 7 (3) ◽  
pp. 100
Author(s):  
Christin Natalia Kalembang ◽  
Gusti Ayu Putu Nilawati ◽  
Bagus Ngurah Mahakrishna
Keyword(s):  
Blood Pressure ◽  
Risk Factor ◽  
Elevated Blood Pressure ◽  
Elevated Blood

scholarly journals Different Influence of Blood Pressure on New-Onset Atrial Fibrillation in Pre- and Postmenopausal Women

Hypertension ◽  
2021 ◽  
Author(s):  
Yun Gi Kim ◽  
Kyung-Do Han ◽  
Do Young Kim ◽  
Yun Young Choi ◽  
Ha Young Choi ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Blood Pressure ◽  
Risk Factor ◽  
Systolic Blood Pressure ◽  
Postmenopausal Women ◽  
Premenopausal Women ◽  
Elevated Blood Pressure ◽  
Elevated Blood ◽  
Onset Atrial Fibrillation ◽  
New Onset

The characteristics of hypertension in pre- and postmenopausal women are different. Hypertension is a known risk factor for new-onset atrial fibrillation (AF), but its interaction with the menopause state is not fully established. We investigated whether menopause influences the adverse impact of high blood pressure on new-onset AF using a nationwide population-based cohort in Korea. People who underwent both a national health check-up and national cancer screening program were included in this study. A total of 3 280 834 women were assessed with 23 781 070 person*year follow-up data. Menopause was observed in 1 439 161 women. The risk of new-onset AF and blood pressure showed a linear relationship in premenopausal women ( P <0.001 for both systolic and diastolic blood pressure). The risk of new-onset AF was increased by 58.8% if systolic blood pressure was ≥160 mm Hg compared with the reference group (100 mm Hg ≤ systolic blood pressure <110 mm Hg; hazard ratio=1.588 [95% CI, 1.383–1.823]) in premenopause group. However, no consistent correlation was observed between blood pressure and the risk of new-onset AF in postmenopausal women. The increased risk of new-onset AF attributable to elevated blood pressure was more pronounced in patients not taking antihypertension medications ( P for interaction <0.001). In conclusion, elevated blood pressure, especially systolic blood pressure, was a significant risk factor for new-onset AF in premenopausal women. Postmenopausal women showed a significantly attenuated association between blood pressure and the risk of new-onset AF. Elevated systolic blood pressure had a more profound impact on new-onset AF in women not taking medications for hypertension.

Epidemiology of Risk Factor Clustering in Elevated Blood Pressure

1998 ◽  
pp. 325-333 ◽  
Author(s):  
William B. Kannel ◽  
Peter W. F. Wilson ◽  
Halit Silbershatz ◽  
Ralph B. D’Agostino
Keyword(s):  
Blood Pressure ◽  
Risk Factor ◽  
Elevated Blood Pressure ◽  
Elevated Blood
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