scholarly journals Relationships of C-reactive protein, uric acid, and glomerular filtration rate to arterial stiffness in Japanese subjects

2005 ◽  
Vol 19 (11) ◽  
pp. 907-913 ◽  
Author(s):  
Y Saijo ◽  
M Utsugi ◽  
E Yoshioka ◽  
N Horikawa ◽  
T Sato ◽  
...  
Keyword(s):  
Uric Acid ◽  
Glomerular Filtration Rate ◽  
Arterial Stiffness ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Japanese Subjects

scholarly journals Clinical Characteristics and Immune Responses of 137 Deceased Patients With COVID-19: A Retrospective Study

2020 ◽  
Vol 10 ◽  
Author(s):  
Ning Cui ◽  
Rongdi Yan ◽  
Chunyuan Qin ◽  
Jingming Zhao
Keyword(s):  
T Cells ◽  
Glomerular Filtration Rate ◽  
Immune Responses ◽  
Glomerular Filtration ◽  
Cardiac Troponin ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Troponin I ◽  
C Reactive Protein ◽  
Reactive Protein

ObjectiveThis study aimed to evaluate the factors associated with death in patients with coronavirus disease 2019 by clarifying the clinical characteristics and immune responses.MethodsThe clinical characteristics and laboratory findings, including cytokine and lymphocyte subsets, were obtained from the electronic medical records of patients in Wuhan Tongji Hospital.ResultsThis study included 836 patients with confirmed COVID-19. In total, 699 (83.6%) were cured and discharged, and 137 (16.4%) died. Our analysis revealed that age ≥ 65 years, male sex, malignancy, chronic obstructive pulmonary disease, dyspnea, dizziness, respiratory rate > 20 bpm, heart rate > 100 bpm, systolic blood pressure < 90 mmHg, neutrophils > 6.3×109/L, lymphopenia, thrombocytopenia, D-dimer ≥ 0.5 mg/L, lactate dehydrogenase > 250 U/L, aspartate aminotransferase > 40 U/L, total bilirubin > 26 μmol/L, albumin < 35 g/L, blood urea nitrogen > 9.5 mmol/L, estimated glomerular filtration rate < 90 ml/min/1.73, elevated cardiac troponin I, N-terminal pro-brain natriuretic peptide ≥ 900 pg/ml, C-reactive protein ≥ 25 mg/L, procalcitonin ≥ 0.05 ng/ml and ferritin > 400 μg/L were associated with death in patients with COVID-19. The multivariate logistic regression analysis revealed that an estimated glomerular filtration rate < 90 ml/min/1.73, elevated cardiac troponin I, C-reactive protein ≥ 25 mg/L and procalcitonin ≥ 0.05 ng/ml were predictive of mortality. Regarding immune responses, IL-2R, IL-6, IL-8, IL-10, and TNFα were remarkably higher in the deceased group at admission, and the levels of IL-2R, IL-6, IL-8, IL-10, and TNFα in the deceased group showed a rapid increase; the dynamics of these cytokines were highly consistent with disease deterioration. Lymphocyte subset analysis revealed that the deceased patients showed significant decreases in lymphocyte counts, especially helper T cells, suppressor T cells and NK cells.ConclusionsThis study identified that an estimated glomerular filtration rate < 90 ml/min/1.73, elevated cardiac troponin I, C-reactive protein ≥ 25 mg/L and procalcitonin ≥ 0.05 ng/ml were predictors of mortality in COVID-19 patients. Elevated cytokine levels and a continued increasing trend, including in IL-2R, IL-6, IL-8, IL-10 and TNFα, and a decrease in lymphocyte subsets, especially helper T cells, suppressor T cells and NK cells, were associated with a poor prognosis.

scholarly journals Serum C-reactive protein and thioredoxin levels in subjects with mildly reduced glomerular filtration rate

2010 ◽  
Vol 11 (1) ◽  
Author(s):  
Shoko Tsuchikura ◽  
Tetsuo Shoji ◽  
Naoko Shimomura ◽  
Ryusuke Kakiya ◽  
Masanori Emoto ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Effect of A Reduction in glomerular filtration rate after NEphrectomy on arterial STiffness and central hemodynamics: Rationale and design of the EARNEST study

2014 ◽  
Vol 167 (2) ◽  
pp. 141-149.e2 ◽  
Author(s):  
William E. Moody ◽  
Laurie A. Tomlinson ◽  
Charles J. Ferro ◽  
Richard P. Steeds ◽  
Patrick B. Mark ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Arterial Stiffness ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Central Hemodynamics

High glomerular filtration rate is associated with arterial stiffness in Chinese population

2017 ◽  
Vol 35 (2) ◽  
pp. 385-391 ◽  
Author(s):  
Lin Lin ◽  
Kui Peng ◽  
Rui Du ◽  
Xiaolin Huang ◽  
Wanwan Sun ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Arterial Stiffness ◽  
Glomerular Filtration ◽  
Chinese Population ◽  
Filtration Rate

P0035URINARY CITRATE AS A MARKER OF RENAL FUNCTION IN PATIENTS WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Francisco-Jose Borrego-Utiel ◽  
Isidoro Herrera ◽  
Enoc Merino Garcia ◽  
Clara Moriana Dominguez ◽  
Victoria Camacho Reina ◽  
...  
Keyword(s):  
Uric Acid ◽  
Glomerular Filtration Rate ◽  
Kidney Disease ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Autosomal Dominant ◽  
Urinary Calcium ◽  
Polycystic Kidney ◽  
Autosomal Dominant Polycystic Kidney ◽  
Urinary Citrate

Abstract Background and Aims In autosomal dominant polycystic kidney disease (ADPKD) is frequent to find low urinary citrate levels. Recently it has been suggested that urinary citrate could be a marker of covert metabolic acidosis. Our aim was to analyze relationship between urinary citrate levels and renal functionality in ADPKD patients. Method We determined citrate, calcium and uric acid in 24-hour collected urine from 91 ADPKD patients Results Urinary citrate/creatinine ratio was 214±158 (range 5.3-678) mg/g Cr with levels significantly higher in females. When considering chronic kidney disease (CKD) stages we observed a progressive decrease in urinary osmolality and in urinary citrate, calcium and uric acid elimination. Low levels of citrate (<300 mg/g Cr) were present in 40% in CKD-1 stage, in 69.7% in CKD-2 stage, 92% in CKD-3 stage and 100% in CKD-4 + 5 stages. Urinary citrate was correlated with serum creatinine (r= -0.66, p<0.001) and eGFR (r= 0.56, p<0.001). Urinary citrate significantly correlated with urinary calcium but correlation with urinary uric acid was weaker. We did not find any correlation with serum bicarbonate. Using multiple lineal regression analysis we found as predictors of urinary citrate to glomerular filtration rate, female gender and urinary calcium levels. In a subgroup of patients we measured total kidney volume and we found an inverse correlation with urinary citrate levels that dissappeared when it was corrected with glomerular filtration rate. We did not also find a relationship between urinary elimination of calcium or uric acid and TKV after adjusting with eGFR. Conclusion Urinary citrate is very frequently reduced in ADPKD patients being present from very early CKD stages. Their levels are inversely correlated with glomerular filtration rate and directly with urinary calcium excretion. We did not found a relathionship with serum bicarbonate. We think that it would be interesting to study urinary citrate in other nephropathies and verify if it could be a marker of covert metabolic acidosis.

High uric acid, reduced glomerular filtration rate and non-alcoholic fatty liver in young people with obesity

2019 ◽  
Vol 43 (4) ◽  
pp. 461-468 ◽  
Author(s):  
P. Di Bonito ◽  
G. Valerio ◽  
M. R. Licenziati ◽  
E. Miraglia del Giudice ◽  
M. G. Baroni ◽  
...  
Keyword(s):  
Uric Acid ◽  
Glomerular Filtration Rate ◽  
Young People ◽  
Fatty Liver ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Alcoholic Fatty Liver ◽  
High Uric Acid

scholarly journals Different alterations of glomerular filtration rate and their association with uric acid in children and adolescents with type 1 diabetes or with overweight/obesity

2020 ◽  
Vol 21 (4) ◽  
pp. 657-663 ◽  
Author(s):  
María P. Santucci ◽  
María L. Muzzio ◽  
Maria S. Peredo ◽  
Lucrecia Brovarone ◽  
Romina Scricciolo ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Uric Acid ◽  
Glomerular Filtration Rate ◽  
Children And Adolescents ◽  
Glomerular Filtration ◽  
Filtration Rate
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