Association between coffee consumption and the estimated glomerular filtration rate in the general Japanese population: preliminary data regarding C-reactive protein concentrations

2010 ◽  
Vol 48 (12) ◽  
Author(s):  
Kazuhiko Kotani ◽  
Naoki Sakane ◽  
Toshiyuki Yamada ◽  
Nobuyuki Taniguchi
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Preliminary Data ◽  
Japanese Population ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Coffee Consumption ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
General Japanese Population

scholarly journals Clinical Characteristics and Immune Responses of 137 Deceased Patients With COVID-19: A Retrospective Study

2020 ◽  
Vol 10 ◽  
Author(s):  
Ning Cui ◽  
Rongdi Yan ◽  
Chunyuan Qin ◽  
Jingming Zhao
Keyword(s):  
T Cells ◽  
Glomerular Filtration Rate ◽  
Immune Responses ◽  
Glomerular Filtration ◽  
Cardiac Troponin ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Troponin I ◽  
C Reactive Protein ◽  
Reactive Protein

ObjectiveThis study aimed to evaluate the factors associated with death in patients with coronavirus disease 2019 by clarifying the clinical characteristics and immune responses.MethodsThe clinical characteristics and laboratory findings, including cytokine and lymphocyte subsets, were obtained from the electronic medical records of patients in Wuhan Tongji Hospital.ResultsThis study included 836 patients with confirmed COVID-19. In total, 699 (83.6%) were cured and discharged, and 137 (16.4%) died. Our analysis revealed that age ≥ 65 years, male sex, malignancy, chronic obstructive pulmonary disease, dyspnea, dizziness, respiratory rate > 20 bpm, heart rate > 100 bpm, systolic blood pressure < 90 mmHg, neutrophils > 6.3×109/L, lymphopenia, thrombocytopenia, D-dimer ≥ 0.5 mg/L, lactate dehydrogenase > 250 U/L, aspartate aminotransferase > 40 U/L, total bilirubin > 26 μmol/L, albumin < 35 g/L, blood urea nitrogen > 9.5 mmol/L, estimated glomerular filtration rate < 90 ml/min/1.73, elevated cardiac troponin I, N-terminal pro-brain natriuretic peptide ≥ 900 pg/ml, C-reactive protein ≥ 25 mg/L, procalcitonin ≥ 0.05 ng/ml and ferritin > 400 μg/L were associated with death in patients with COVID-19. The multivariate logistic regression analysis revealed that an estimated glomerular filtration rate < 90 ml/min/1.73, elevated cardiac troponin I, C-reactive protein ≥ 25 mg/L and procalcitonin ≥ 0.05 ng/ml were predictive of mortality. Regarding immune responses, IL-2R, IL-6, IL-8, IL-10, and TNFα were remarkably higher in the deceased group at admission, and the levels of IL-2R, IL-6, IL-8, IL-10, and TNFα in the deceased group showed a rapid increase; the dynamics of these cytokines were highly consistent with disease deterioration. Lymphocyte subset analysis revealed that the deceased patients showed significant decreases in lymphocyte counts, especially helper T cells, suppressor T cells and NK cells.ConclusionsThis study identified that an estimated glomerular filtration rate < 90 ml/min/1.73, elevated cardiac troponin I, C-reactive protein ≥ 25 mg/L and procalcitonin ≥ 0.05 ng/ml were predictors of mortality in COVID-19 patients. Elevated cytokine levels and a continued increasing trend, including in IL-2R, IL-6, IL-8, IL-10 and TNFα, and a decrease in lymphocyte subsets, especially helper T cells, suppressor T cells and NK cells, were associated with a poor prognosis.

scholarly journals Serum C-reactive protein and thioredoxin levels in subjects with mildly reduced glomerular filtration rate

2010 ◽  
Vol 11 (1) ◽  
Author(s):  
Shoko Tsuchikura ◽  
Tetsuo Shoji ◽  
Naoko Shimomura ◽  
Ryusuke Kakiya ◽  
Masanori Emoto ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Association between habitual coffee consumption and normal or increased estimated glomerular filtration rate in apparently healthy adults

2009 ◽  
Vol 103 (2) ◽  
pp. 149-152 ◽  
Author(s):  
Kei Nakajima ◽  
Kazuki Hirose ◽  
Midori Ebata ◽  
Kumiko Morita ◽  
Hiromi Munakata
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Kidney Function ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Coffee Consumption ◽  
Healthy Adults ◽  
Cardiovascular Risks ◽  
Cross Sectional ◽  
Apparently Healthy

Habitual coffee consumption is associated with the prevention of type 2 diabetes, which often accompanies diabetic nephropathy. However, the relationship between coffee consumption and kidney function is unclear. Therefore, we investigated the associations between habitual coffee consumption and kidney function and damage assessed by the estimated glomerular filtration rate (eGFR) and proteinuria using dipstick urinalysis, respectively, in a cross-sectional study of 342 apparently healthy adults. Habitual coffee consumption was defined as drinking one or more cups of coffee per d. eGFR in coffee consumers (n 182; 80·1 (sd 15·0) ml/min per 1·73 m2) was significantly higher than that in non-coffee consumers (n 160; 76·9 (sd 12·6) ml/min per 1·73 m2) (P < 0·05). Multivariate logistic analysis showed that, compared with non-coffee consumption, coffee consumption was significantly associated with normal or increased eGFR (NIGFR) ( ≥ 90 ml/min per 1·73 m2), but not proteinuria, which was not attenuated, even after adjustment for age, sex, smoking, tea consumption and other cardiovascular risks (OR 2·91; 95 % CI 1·51, 5·61; P = 0·001). When we took into account eGFR measured 1 year before in a subgroup of the subjects (n 262), coffee consumption (n 142) had a significant relationship with eGFR, which was consistently higher with a difference of 4·0 ml/min per 1·73 m2 compared with non-coffee consumption (P = 0·01; two-way repeated ANOVA). Similar associations were observed in both sexes when data were reanalysed according to sex. In conclusion, our findings suggest that habitual coffee consumption is associated with NIGFR independently of clinical confounders. Further studies are needed to confirm this association and to explore whether the effect of coffee consumption on eGFR is beneficial for the kidney.

scholarly journals The relation between estimated glomerular filtration rate (eGFR) and coffee consumption in the Japanese

Health ◽  
2011 ◽  
Vol 03 (09) ◽  
pp. 549-552 ◽  
Author(s):  
Nobuyuki Miyatake ◽  
Kenichi Shikata ◽  
Hirofumi Makino ◽  
Takeyuki Numata
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Coffee Consumption
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