Chemical biology—identification of small molecule modulators of cellular activity by natural product inspired synthesis

2008 ◽  
Vol 37 (7) ◽  
pp. 1361 ◽  
Author(s):  
Katja Hübel ◽  
Torben Leßmann ◽  
Herbert Waldmann
Keyword(s):  
Natural Product ◽  
Small Molecule ◽  
Chemical Biology ◽  
Cellular Activity ◽  
Small Molecule Modulators

Inhibitor Binding Sites in the Protein Tyrosine Phosphatase SHP-2

2020 ◽  
Vol 20 (11) ◽  
pp. 1017-1030
Author(s):  
Haonan Zhang ◽  
Zhengquan Gao ◽  
Chunxiao Meng ◽  
Xiangqian Li ◽  
Dayong Shi
Keyword(s):  
Small Molecule ◽  
Protein Tyrosine Phosphatase ◽  
Binding Sites ◽  
Drug Target ◽  
Tyrosine Phosphatase ◽  
Cancer Drug ◽  
Cellular Activity ◽  
Binding Modes ◽  
Inhibitor Binding ◽  
Protein Tyrosine

Protein tyrosine phosphatase 2 (SHP-2) has long been proposed as a cancer drug target. Several small-molecule compounds with different mechanisms of SHP-2 inhibition have been reported, but none are commercially available. Pool selectivity over protein tyrosine phosphatase 1 (SHP-1) and a lack of cellular activity have hindered the development of selective SHP-2 inhibitors. In this review, we describe the binding modes of existing inhibitors and SHP-2 binding sites, summarize the characteristics of the sites involved in selectivity, and identify the suitable groups for interaction with the binding sites.

An overview on interactions between natural product-derived β-glucan and small-molecule compounds

2021 ◽  
Vol 261 ◽  
pp. 117850
Author(s):  
Xiao-Hui Fang ◽  
Ming-Yue Zou ◽  
Fu-Quan Chen ◽  
Hui Ni ◽  
Shao-Ping Nie ◽  
...  
Keyword(s):  
Natural Product ◽  
Small Molecule

scholarly journals Phenotypic approaches to small-molecule discovery in chemical biology

2021 ◽  
Vol 28 (3) ◽  
pp. 245
Author(s):  
Bridget K. Wagner ◽  
Mishtu Dey
Keyword(s):  
Small Molecule ◽  
Chemical Biology

scholarly journals Small-molecule modulators of inward rectifier K+channels: recent advances and future possibilities

2010 ◽  
Vol 2 (5) ◽  
pp. 757-774 ◽  
Author(s):  
Gautam Bhave ◽  
Daniel Lonergan ◽  
Brian A Chauder ◽  
Jerod S Denton
Keyword(s):  
Small Molecule ◽  
Inward Rectifier ◽  
K Channels ◽  
Recent Advances ◽  
Small Molecule Modulators

Polyamines: Naturally occurring small molecule modulators of electrostatic protein–protein interactions

2010 ◽  
Vol 104 (2) ◽  
pp. 118-125 ◽  
Author(s):  
Anja Berwanger ◽  
Susanne Eyrisch ◽  
Inge Schuster ◽  
Volkhard Helms ◽  
Rita Bernhardt
Keyword(s):  
Small Molecule ◽  
Protein Interactions ◽  
Protein Protein Interactions ◽  
Naturally Occurring ◽  
Small Molecule Modulators
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