pH-responsive hierarchical transformation of charged lipid assemblies within polyelectrolyte gel layers with applications for controlled drug release and MR imaging contrast

2014 ◽  
Vol 2 (31) ◽  
pp. 4988-4992 ◽  
Author(s):  
Yi-Fong Huang ◽  
Wen-Hsuan Chiang ◽  
Wen-Chia Huang ◽  
Hsin-Hung Chen ◽  
Ming-Yin Shen ◽  
...  
Keyword(s):  
Drug Release ◽  
Acrylic Acid ◽  
Mr Imaging ◽  
Controlled Drug Release ◽  
Ph Responsive ◽  
Morphological Transformation ◽  
Polyelectrolyte Gel ◽  
Acid Gel ◽  
Lipid Assemblies ◽  
Poly Acrylic Acid

Cationic DOTAP assemblies within poly(acrylic acid) gel effectively modulate drug release and MR imaging contrast by pH-induced morphological transformation.

“Smart” carboxymethylchitosan hydrogels crosslinked with poly(N-isopropylacrylamide) and poly(acrylic acid) for controlled drug release

2015 ◽  
Vol 42 ◽  
pp. 26-36 ◽  
Author(s):  
Rathanon Jankaew ◽  
Nantharak Rodkate ◽  
Supaporn Lamlertthon ◽  
Boonjira Rutnakornpituk ◽  
Uthai Wichai ◽  
...  
Keyword(s):  
Drug Release ◽  
Acrylic Acid ◽  
Controlled Drug Release ◽  
Poly Acrylic Acid

Poly(acrylic acid)-grafted hydrophobic weak acid gels as mucoadhesives for controlled drug release

2019 ◽  
Vol 164 ◽  
pp. 108372
Author(s):  
Ayla C. Vea-Barragan ◽  
Emilio Bucio ◽  
David Quintanar-Guerrero ◽  
Maria L. Zambrano-Zaragoza ◽  
Samuel G. Meléndez-López ◽  
...  
Keyword(s):  
Drug Release ◽  
Acrylic Acid ◽  
Controlled Drug Release ◽  
Weak Acid ◽  
Poly Acrylic Acid

scholarly journals pH-Sensitive Polyampholyte Microgels of Poly(Acrylic Acid-co-Vinylamine) as Injectable Hydrogel for Controlled Drug Release

Polymers ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 285 ◽  
Author(s):  
Yanmin Chen ◽  
Peijian Sun
Keyword(s):  
Drug Release ◽  
Acrylic Acid ◽  
Zeta Potential ◽  
Suspension Polymerization ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Swelling Ratio ◽  
Sustained Drug Release ◽  
Injectable Hydrogel ◽  
Poly Acrylic Acid

pH-sensitive polyampholyte microgels of poly(acrylic acid-co-vinylamine) (P(AA-co-VAm)) were developed as an injectable hydrogel for controlled drug release. The microgels of P(AA-co-VAm) were prepared via inverse suspension polymerization of acrylic acid and N-vinylformamide followed by hydrolysis of poly(N-vinylformamide) (PNVF) chains of the resultant microgels under basic condition. The pH-sensitivity of the P(AA-co-VAm) microgels in zeta potential and swelling ratio were investigated using a zeta potential analyzer and optical microscope. The results showed that both the zeta potential and the swelling ratio of the microgels were highly affected by the solution pH. By changing the pH of P(AA-co-VAm) microgel dispersion, the interparticle interaction and the swelling ratio of the microgels could be well adjusted and a colloidal hydrogel could be fabricated at moderate pH, showing a pH-triggered reversible fluid-gel transition. Using the polyampholyte P(AA-co-VAm) microgels as an injectable hydrogel drug release system, a sustained drug release could be achieved, indicating the great potentials of the pH-sensitive P(AA-co-VAm) microgels for controlled drug delivery.

Soluble and crosslinked hydrophilic films based on compositions of poly(acrylic acid) and poly(2-hydroxyethyl vinyl ether) for controlled drug release

2003 ◽  
Vol 90 (1) ◽  
pp. 137-142 ◽  
Author(s):  
Z. S. Nurkeeva ◽  
G. A. Mun ◽  
V. V. Khutoryanskiy ◽  
A. B. Bitekenova ◽  
A. B. Dzhusupbekova ◽  
...  
Keyword(s):  
Drug Release ◽  
Acrylic Acid ◽  
Vinyl Ether ◽  
Controlled Drug Release ◽  
Poly Acrylic Acid

scholarly journals Synthesis of methotrexate-loaded tantalum pentoxide–poly(acrylic acid) nanoparticles for controlled drug release applications

2019 ◽  
Vol 538 ◽  
pp. 286-296 ◽  
Author(s):  
Kathrin Bogusz ◽  
Malgorzata Zuchora ◽  
Vitor Sencadas ◽  
Moeava Tehei ◽  
Michael Lerch ◽  
...  
Keyword(s):  
Drug Release ◽  
Acrylic Acid ◽  
Controlled Drug Release ◽  
Tantalum Pentoxide ◽  
Poly Acrylic Acid
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