Conjugation of multivalent ligands to gold nanoshells and designing a dual modality imaging probe

2015 ◽  
Vol 3 (9) ◽  
pp. 1788-1800 ◽  
Author(s):  
Mathieu Bédard ◽  
Pramod K. Avti ◽  
Tina Lam ◽  
Léonie Rouleau ◽  
Jean-Claude Tardif ◽  
...  
Keyword(s):  
Gold Nanoshells ◽  
Multivalent Ligands ◽  
Dual Modality ◽  
Imaging Probe ◽  
Hollow Gold Nanoshells ◽  
Dual Modality Imaging ◽  
Dual Imaging

Hollow gold nanoshells functionalized with branched multivalent ligands provide an excellent platform to develop nanoprobes with dual imaging capabilities.

A novel Affibody bioconjugate for dual-modality imaging of ovarian cancer

2014 ◽  
Vol 50 (85) ◽  
pp. 12832-12835 ◽  
Author(s):  
Yihong Wang ◽  
Zheng Miao ◽  
Gang Ren ◽  
Yingding Xu ◽  
Zhen Cheng
Keyword(s):  
Ovarian Cancer ◽  
Optical Imaging ◽  
Tumor Imaging ◽  
Dual Modality ◽  
Imaging Probe ◽  
Imaging Quality ◽  
Metal Chelator ◽  
Dual Modality Imaging ◽  
Dual Imaging

An Affibody based dual imaging probe (PET and optical imaging) has been successfully developed. Dendrimer PAMAM G0 was used as a platform to assemble an NIRF dye, a metal chelator, and Affibody for dual modality imaging of ovarian cancer. Excellent tumor imaging quality was achieved in both modalities in the living tumor mice models.

scholarly journals Ferumoxytol-based Dual-modality Imaging Probe for Detection of Stem Cell Transplant Rejection

2018 ◽  
Vol 2 (4) ◽  
pp. 306-319 ◽  
Author(s):  
Kai Li ◽  
Carmel T. Chan ◽  
Hossein Nejadnik ◽  
Olga D. Lenkov ◽  
Cody Wolterman ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplant ◽  
Transplant Rejection ◽  
Cell Transplant ◽  
Dual Modality ◽  
Imaging Probe ◽  
Dual Modality Imaging

A functionalized heterobimetallic99mTc/Re complex as a potential dual-modality imaging probe: synthesis, photophysical properties, cytotoxicity and cellular imaging investigations

2014 ◽  
Vol 43 (2) ◽  
pp. 439-450 ◽  
Author(s):  
Alison François ◽  
Céline Auzanneau ◽  
Valérie Le Morvan ◽  
Chantal Galaup ◽  
Hannah S. Godfrey ◽  
...  
Keyword(s):  
Photophysical Properties ◽  
Cellular Imaging ◽  
Dual Modality ◽  
Imaging Probe ◽  
Dual Modality Imaging

scholarly journals Dual-Modality Imaging Probes with High Magnetic Relaxivity and Near-Infrared Fluorescence Based Highly Aminated Mesoporous Silica Nanoparticles

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Zhu Fei-Peng ◽  
Chen Guo-Tao ◽  
Wang Shou-Ju ◽  
Liu Ying ◽  
Tang Yu-Xia ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Near Infrared ◽  
Mesoporous Silica Nanoparticles ◽  
Near Infrared Fluorescence ◽  
Dual Modality ◽  
Imaging Probe ◽  
Nir Fluorescence ◽  
Imaging Probes ◽  
Dual Modality Imaging

Dual-modal imaging by combining magnetic resonance (MR) and near-infrared (NIR) fluorescence can integrate the advantages of high-resolution anatomical imaging with high sensitivity in vivo fluorescent imaging, which is expected to play a significant role in biomedical researches. Here we report a dual-modality imaging probe (NIR/MR-MSNs) fabricated by conjugating NIR fluorescent heptamethine dyes (IR-808) and MR contrast agents (Gd-DTPA) within highly aminated mesoporous silica nanoparticles (MSNs-NH2). The dual-modality imaging probes NIR/MR-MSNs possess a size of ca. 120 nm. The NIR/MR-MSNs show not only near-infrared fluorescence imaging property with an emission peak at 794 nm, but also highly MRT1relaxivity of 14.54 mM−1 s−1, which is three times more than Gd-DTPA. In vitro experiment reveals high uptake and retention abilities of the nanoprobes, while cell viability assay demonstrates excellent cytocompatibility of the dual-modality imaging probe. After intratumor injection with the NIR/MR-MSNs, MR imaging shows clear anatomical border of the enhanced tumor region while NIR fluorescence exhibits high sensitive tumor detection ability. These intriguing features suggest that this newly developed dual-modality imaging probes have great potential in biomedical imaging.

scholarly journals Tumor-targeted Dual-modality Imaging to Improve Intraoperative Visualization of Clear Cell Renal Cell Carcinoma: A First in Man Study

Theranostics ◽  
2018 ◽  
Vol 8 (8) ◽  
pp. 2161-2170 ◽  
Author(s):  
Marlène C. Hekman ◽  
Mark Rijpkema ◽  
Constantijn H. Muselaers ◽  
Egbert Oosterwijk ◽  
Christina A. Hulsbergen-Van de Kaa ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Dual Modality ◽  
Dual Modality Imaging ◽  
Intraoperative Visualization

scholarly journals Initial in vitro and in vivo assessment of Au@DTDTPA-RGD nanoparticles for Gd-MRI and 68Ga-PET dual modality imaging

2015 ◽  
Vol 2 (Suppl 1) ◽  
pp. A89 ◽  
Author(s):  
Charalmpos Tsoukalas ◽  
Gautier Laurent ◽  
Gloria Jiménez Sánchez ◽  
Theodoros Tsotakos ◽  
Rana Bazzi ◽  
...  
Keyword(s):  
Dual Modality ◽  
Dual Modality Imaging ◽  
In Vivo Assessment

scholarly journals Dual-Modality Imaging of Cancer with SPECT/CT

2002 ◽  
Vol 1 (6) ◽  
pp. 449-458 ◽  
Author(s):  
Bruce H. Hasegawa ◽  
Kenneth H. Wong ◽  
Koji Iwata ◽  
William C. Barber ◽  
Andrew B. Hwang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Em Algorithm ◽  
Photon Emission ◽  
Imaging Systems ◽  
Patient Specific ◽  
Emission Computed Tomography ◽  
Functional Information ◽  
Dual Modality ◽  
Photon Attenuation ◽  
Dual Modality Imaging

Dual-modality imaging is an in vivo diagnostic technique that obtains structural and functional information directly from patient studies in a way that cannot be achieved with separate imaging systems alone. Dual-modality imaging systems are configured by combining computed tomography (CT) with radionuclide imaging (using positron emission tomography (PET) or single-photon emission computed tomography (SPECT)) on a single gantry which allows both functional and structural imaging to be performed during a single imaging session without having the patient leave the imaging system. A SPECT/CT system developed at UCSF is being used in a study to determine if dual-modality imaging offers advantages for assessment of patients with prostate cancer using111 In-ProstaScint®, a radiolabeled antibody for the prostate-specific membrane antigen.111 In-ProstaScint® images are reconstructed using an iterative maximum-likelihood expectation-maximization (ML-EM) algorithm with correction for photon attenuation using a patient-specific map of attenuation coefficients derived from CT. The ML-EM algorithm accounts for the dual-photon nature of the111 In-labeled radionuclide, and incorporates correction for the geometric response of the radionuclide collimator. The radionuclide image then can be coregistered and overlaid in color on a grayscale CT image for improved localization of the functional information from SPECT. Radionuclide images obtained with SPECT/CT and reconstructed using ML-EM with correction for photon attenuation and collimator response improve image quality in comparison to conventional radionuclide images obtained with filtered backprojection reconstruction. These results illustrate the potential advantages of dual-modality imaging for improving the quality and the localization of radionuclide uptake for staging disease, planning treatment, and monitoring therapeutic response in patients with cancer.

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