Facile synthesis of folic acid-functionalized iron oxide nanoparticles with ultrahigh relaxivity for targeted tumor MR imaging

RGD peptide-functionalized iron oxide nanoparticles with ultrahigh relaxivity can be synthesized for targeted MR imaging of αvβ3 integrin-overexpressing tumors.

Download Full-text

Shaping and Cellular Uptake of Folic Acid Coated Gold and Magnetite Nanoparticles

Current Nanomedicine ◽

10.2174/2468187308666180913113827 ◽

2019 ◽

Vol 9 (2) ◽

pp. 166-172

Author(s):

Ahmed A.G. El-Shahawy ◽

Gamal Elghnam ◽

Alsayed A.M. Alsherbini

Keyword(s):

Folic Acid ◽

Iron Oxide ◽

Tumor Cells ◽

Iron Oxide Nanoparticles ◽

Individual Cell ◽

Oxide Nanoparticles ◽

Cellular Compartment ◽

Specific Tumor ◽

Uv Visible

Background:Gold and Iron Oxide nanoparticles NPs play as nanocarriers for a specific drug delivery and contrast agents. Intercellular uptake of these nanoparticles and targeting to individual cell and sub-cellular compartment is essential.Objective:The aim of the current study is to evaluate the intracellular uptake of these NPs to specific tumor cells in vitro conjugated with folic acid with a goal of enhancing the efficiency of specific targeting to tumor cells.Methods:We synthesized the nanoparticles by a chemical method and characterized by UV-Visible, FTIR, XRD, and TEM.Results & Conclusion:The results revealed the conjugation of Gold and Iron Oxide nanoparticles with folic acid increased the intercellular uptake with high percent compared to non- conjugated nanoparticles.

Download Full-text

Macrophage-Laden Gold Nanoflowers Embedded with Ultrasmall Iron Oxide Nanoparticles for Enhanced Dual-Mode CT/MR Imaging of Tumors

Pharmaceutics ◽

10.3390/pharmaceutics13070995 ◽

2021 ◽

Vol 13 (7) ◽

pp. 995

Author(s):

Yucheng Peng ◽

Xiaomeng Wang ◽

Yue Wang ◽

Yue Gao ◽

Rui Guo ◽

...

Keyword(s):

Iron Oxide ◽

Mr Imaging ◽

Iron Oxide Nanoparticles ◽

Colloidal Stability ◽

Pamam Dendrimer ◽

Great Promise ◽

Oxide Nanoparticles ◽

Dual Mode ◽

Gold Nanoflowers ◽

Average Size

The design of multimodal imaging nanoplatforms with improved tumor accumulation represents a major trend in the current development of precision nanomedicine. To this end, we report herein the preparation of macrophage (MA)-laden gold nanoflowers (NFs) embedded with ultrasmall iron oxide nanoparticles (USIO NPs) for enhanced dual-mode computed tomography (CT) and magnetic resonance (MR) imaging of tumors. In this work, generation 5 poly(amidoamine) (G5 PAMAM) dendrimer-stabilized gold (Au) NPs were conjugated with sodium citrate-stabilized USIO NPs to form hybrid seed particles for the subsequent growth of Au nanoflowers (NFs). Afterwards, the remaining terminal amines of dendrimers were acetylated to form the dendrimer-stabilized Fe3O4/Au NFs (for short, Fe3O4/Au DSNFs). The acquired Fe3O4/Au DSNFs possess an average size around 90 nm, display a high r1 relaxivity (1.22 mM−1 s−1), and exhibit good colloidal stability and cytocompatibility. The created hybrid DSNFs can be loaded within MAs without producing any toxicity to the cells. Through the mediation of MAs with a tumor homing and immune evasion property, the Fe3O4/Au DSNFs can be delivered to tumors more efficiently than those without MAs after intravenous injection, thus significantly improving the MR/CT imaging performance of tumors. The developed MA-mediated delivery system may hold great promise for enhanced tumor delivery of other contrast agents or nanomedicines for precision cancer nanomedicine applications.

Download Full-text

Contrast-enhanced MR imaging of atherosclerosis using citrate-coated superparamagnetic iron oxide nanoparticles: calcifying microvesicles as imaging target for plaque characterization

International Journal of Nanomedicine ◽

10.2147/ijn.s38702 ◽

2013 ◽

pp. 767 ◽

Cited By ~ 3

Author(s):

Matthias Taupitz ◽

Wagner ◽

Schnorr ◽

Ludwig ◽

Stangl ◽

...

Keyword(s):

Iron Oxide ◽

Mr Imaging ◽

Iron Oxide Nanoparticles ◽

Superparamagnetic Iron Oxide ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Plaque Characterization ◽

Contrast Enhanced

Download Full-text

LAPONITE®-stabilized iron oxide nanoparticles for in vivo MR imaging of tumors

Biomaterials Science ◽

10.1039/c5bm00508f ◽

2016 ◽

Vol 4 (3) ◽

pp. 474-482 ◽

Cited By ~ 24

Author(s):

Ling Ding ◽

Yong Hu ◽

Yu Luo ◽

Jianzhi Zhu ◽

Yilun Wu ◽

...

Keyword(s):

Iron Oxide ◽

Mr Imaging ◽

Iron Oxide Nanoparticles ◽

Colloidal Stability ◽

Coprecipitation Method ◽

Oxide Nanoparticles

LAPONITE®-stabilized iron oxide nanoparticles with great colloidal stability and high T2 relaxivity are synthesized by a facile controlled coprecipitation method, and can significantly enhance the contrast of tumors in vivo, indicating their tremendous potential in MR imaging applications.

Download Full-text