Smart pH-responsive and high doxorubicin loading nanodiamond for in vivo selective targeting, imaging, and enhancement of anticancer therapy

2016 ◽  
Vol 4 (29) ◽  
pp. 5046-5058 ◽  
Author(s):  
Lin Li ◽  
Lu Tian ◽  
Yongli Wang ◽  
Wenjing Zhao ◽  
Fangqin Cheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Anticancer Therapy ◽  
Effective Strategy ◽  
Ph Responsive ◽  
Selective Targeting ◽  
Delivery Platform

We introduce a simple and effective strategy to design a promising drug delivery platform for improving the biomedical applications of smart nanodiamond carriers.

Polymeric prodrugs conjugated with reduction-sensitive dextran–camptothecin and pH-responsive dextran–doxorubicin: an effective combinatorial drug delivery platform for cancer therapy

2016 ◽  
Vol 7 (25) ◽  
pp. 4198-4212 ◽  
Author(s):  
Dongling Cao ◽  
Jinlin He ◽  
Jiaying Xu ◽  
Mingzu Zhang ◽  
Lin Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Anticancer Activity ◽  
Ph Responsive ◽  
Delivery Platform ◽  
Stimuli Sensitive

Two types of stimuli-sensitive polymeric prodrugs for combinatorial cancer therapy have been prepared and found to exhibit favorable anticancer activity in vitro and in vivo.

scholarly journals ROS-triggered self-accelerating drug release nanosystem with charge conversion for enhanced cancer therapy

2020 ◽  
Author(s):  
Xinyi Zhang ◽  
Tiantian Zhu ◽  
Yaxin Miao ◽  
Lu Zhou ◽  
Weifang Zhang
Keyword(s):  
Drug Release ◽  
Tumor Tissue ◽  
Anticancer Therapy ◽  
Cell Uptake ◽  
Oxygen Species ◽  
Anticancer Drug Delivery ◽  
Tocopheryl Succinate ◽  
Delivery Platform

Abstract Background: The enhancement tumor retention and of cellular uptake of drugs are important factors in maximizing anticancer therapy and minimizing side effects of encapsulated drugs. Herein, a delivery nanoplatform with a pH-triggered charge-reversal capability and self-amplifiable reactive oxygen species (ROS) level inducing drug release pattern was constructed by encapsulating doxorubicin (DOX) in pH/ROS-responsive polymeric micelle.Results: The surface charge of this system can be converted from negative to positive for enhanced tumor cell uptake in response to the weakly acidic tumor tissue. In addition, methionine-based system was dissociated in a ROS-rich intracellular environment, resulting in a phase transition and the release of DOX. Then, the exposed α-tocopheryl succinate (α-TOS) segments can be capable of producing ROS, which further induced the self-amplifiable disassembly of the micelles and drug release. Conclusions: We confirmed efficient DOX delivery into cancer cells, upregulation of tumoral ROS level and induction of the apoptotic capability in vitro. The system exhibited outstanding tumor inhibition capability in vivo, indicating that dual stimuli nanosytem would be great potential as an anticancer drug delivery platform.

Understanding Microdroplet Formations for Biomedical Applications

2008 ◽  
Author(s):  
Salil Desai ◽  
Anthony Moore ◽  
Benjamin Harrison ◽  
Jagannathan Sankar
Keyword(s):  
Drug Delivery ◽  
Sodium Chloride ◽  
Sodium Alginate ◽  
Calcium Chloride ◽  
Biomedical Applications ◽  
Tissue Scaffolds ◽  
Ambient Conditions ◽  
On Demand ◽  
Drop On Demand

This paper focuses on understanding microdroplet formation of sodium alginate biopolymer at various concentrations utilizing drop-on-demand inkjet technology. We investigate the effect of sodium chloride on the rheology of sodium alginate and derive a correlation between the size of the droplet versus the size of the microcapsules formed. Varying sizes of microcapsules are formed based on different concentrations of calcium chloride solvent. This understanding will give insight for fabricating drug delivery capsules and tissue scaffolds that are subject to extreme ambient conditions when interfaced with in-vivo environments.

A Review on Application of Novel Solid Nanostructures in Drug Delivery

2018 ◽  
Vol 53 ◽  
pp. 22-36 ◽  
Author(s):  
Habibollah Faraji ◽  
Reza Nedaeinia ◽  
Esmaeil Nourmohammadi ◽  
Bizan Malaekeh-Nikouei ◽  
Hamid Reza Sadeghnia ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Therapy ◽  
Biomedical Applications ◽  
Imaging Biomarkers ◽  
Cellular Functions ◽  
Scientific Innovation ◽  
Wide Range ◽  
Targeted Drug

Nanotechnology as a multidisciplinary and scientific innovation plays an important role in numerous biomedical applications, such as molecular imaging, biomarkers and biosensors and also drug delivery. A wide range of studies have been conducted on using of nanoparticles for early diagnosis and targeted drug therapy of various diseases. In fact, the small size, customized surface, upgraded solubility, or multi-functionality of nanoparticles enabled them to interact with complex cellular functions in new ways which opened many doors and created new biomedical applications. These studies demonstrated that nanotechnology vehicles can formulate biological products effectively, and this nano-formulated products with a potent ability against different diseases, were represented to have better biocompatibility, bioaccessibility and efficacy, under in vitro and in vivo conditions.

scholarly journals Stability of Engineered Micro or Nanobubbles for Biomedical Applications

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1089
Author(s):  
Beomjin Park ◽  
Semi Yoon ◽  
Yonghyun Choi ◽  
Jaehee Jang ◽  
Soomin Park ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Ultrasonic Field ◽  
Nanometer Scale ◽  
Factors Affecting ◽  
The Core ◽  
Bubble Structure ◽  
The Stability ◽  
The Relationship

A micro/nanobubble (MNB) refers to a bubble structure sized in a micrometer or nanometer scale, in which the core is separated from the external environment and is normally made of gas. Recently, it has been confirmed that MNBs can be widely used in angiography, drug delivery, and treatment. Thus, MNBs are attracting attention as they are capable of constructing a new contrast agent or drug delivery system. Additionally, in order to effectively use an MNB, the method of securing its stability is also being studied. This review highlights the factors affecting the stability of an MNB and the stability of the MNB within the ultrasonic field. It also discusses the relationship between the stability of the bubble and its applicability in vivo.

Construction of pH-responsive drug delivery platform with calcium carbonate microspheres induced by chitosan gels

2018 ◽  
Vol 44 (7) ◽  
pp. 7902-7907 ◽  
Author(s):  
Jingwei Wang ◽  
Yong Kong ◽  
Feng Liu ◽  
Dan Shou ◽  
Yongxin Tao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Calcium Carbonate ◽  
Ph Responsive ◽  
Delivery Platform

scholarly journals Construction of a pH-responsive drug delivery platform based on the hybrid of mesoporous silica and chitosan

2021 ◽  
Vol 25 (1) ◽  
pp. 101174
Author(s):  
Keliang Zhang ◽  
Jun Gao ◽  
Shangji Li ◽  
Ting Ma ◽  
Linhong Deng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Ph Responsive ◽  
Delivery Platform

Improved in vivo tumor therapy via host–guest complexation

2016 ◽  
Vol 4 (15) ◽  
pp. 2691-2696 ◽  
Author(s):  
Yong Yao ◽  
Yang Wang ◽  
Ruibo Zhao ◽  
Li Shao ◽  
Ruikang Tang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Intracellular Ph ◽  
Tumor Therapy ◽  
Controlled Drug Delivery ◽  
Water Soluble ◽  
Ph Responsive ◽  
Mesoporous Nanoparticles

A decomposable and intracellular pH-responsive drug delivery system by immobilizing a water-soluble pillar[5]arene onto hollow mesoporous nanoparticles through host–guest complexation was successfully prepared and its application in controlled drug delivery in vitro and in vivo was also investigated.

An Investigation into the In Vivo Performance Variability of pH Responsive Polymers for Ileo-Colonic Drug Delivery Using Gamma Scintigraphy in Humans

2006 ◽  
Vol 95 (12) ◽  
pp. 2760-2766 ◽  
Author(s):  
Valentine C. Ibekwe ◽  
Fang Liu ◽  
Hala M. Fadda ◽  
Mandeep K. Khela ◽  
David F. Evans ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gamma Scintigraphy ◽  
Ph Responsive ◽  
Responsive Polymers ◽  
Colonic Drug Delivery ◽  
Performance Variability ◽  
Ph Responsive Polymers
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