How Bugs Kill Bugs: Progress and Challenges in Bacteriocin Research

2012 ◽  
Vol 40 (6) ◽  
pp. 1433-1437 ◽  
Author(s):  
Christopher N. Penfold ◽  
Daniel Walker ◽  
Colin Kleanthous
Keyword(s):  
Escherichia Coli ◽  
Biomedical Applications ◽  
Cell Envelope ◽  
Scientific Career ◽  
East Anglia ◽  
The Third ◽  
The World ◽  
Oral Communications ◽  
The University

A Biochemical Society Focused Meeting on bacteriocins was held at the University of Nottingham on 16–18 July 2012 to mark the retirement of Professor Richard James and honour a scientific career of more than 30 years devoted to an understanding of the biology of colicins, bacteriocins produced by Escherichia coli. This meeting was the third leg of a triumvirate of symposia that included meetings at the Île de Bendor, France, in 1991 and the University of East Anglia, Norwich, U.K., in 1998, focused on bringing together leading experts in basic and applied bacteriocin research. The symposium which attracted 70 attendees consisted of 18 invited speakers and 22 selected oral communications spread over four themes: (i) Role of bacteriocins in bacterial ecology, (ii) Mode of action of bacteriocins, (ii) Mechanisms of bacteriocin import across the cell envelope, and (iv) Biotechnological and biomedical applications of bacteriocins. Speakers and poster presenters travelled from around the world, including the U.S.A., Japan, Asia and Europe, to showcase the latest developments in their scientific research.

scholarly journals Mellem Klosteret og Verden

2020 ◽  
Vol 82 (1-2) ◽  
pp. 22-39
Author(s):  
Mette Birkedal Bruun
Keyword(s):  
Seventeenth Century ◽  
Contemporary Society ◽  
Doctoral Thesis ◽  
The Third ◽  
The World ◽  
Central Notion ◽  
Before And After ◽  
The University

The article presents Armand-Jean de Rancé’s reform of the Cistercian abbey of La Trappe. It positions Rancé’s ascetic programme within the wider devotional culture of seventeenth-century France, and explores in three registers the inherent dynamic between withdrawal from the world and engagement with the world. The first register concerns the abbot’s biography, the argument being that the familial, societal and ecclesiastical ircles inhabited by Rancé before and after his conversion are more closely connected than has been traditionally seen. The second is dedicated to the position of La Trappe in contemporary society and a discussion of the continuous traffic across the monastic wall of texts, guests, rumours and myths. The third involves an examination of the role of withdrawal and engagement in Rancé’s reform and its ascetic programme, showing how the abbot expounds the central notion of solitude as a place, a condition and a strategy. The article presents key insights from the author’s doctoral thesis, which was defended at the University of Copenhagen in June 2017.

COVID-19: implications for NHS Staff

2020 ◽  
Vol 14 (4) ◽  
pp. 193-197
Author(s):  
Alan Glasper
Keyword(s):  
World Health ◽  
The Novel ◽  
Emeritus Professor ◽  
The World ◽  
Clinical Environments ◽  
Public Health Institutions ◽  
Health Institutions ◽  
Health Organization ◽  
The University

In light of the emergence in China of COVID-19, the novel corona virus, emeritus professor Alan Glasper, from the University of Southampton discusses the role of the World Health Organization and other public health institutions in responding to potential new global pandemics and deliberates on the role of NHS staff in coping with infectious disease in clinical environments.

scholarly journals The university-industry relationship under diferent approaches: the entrepreneurial university to academic capitalism

Educação ◽  
2017 ◽  
Vol 40 (1) ◽  
pp. 73
Author(s):  
Evandro Coggo Cristofoletti ◽  
Milena Pavan Serafim
Keyword(s):  
Academic Capitalism ◽  
Public Institutions ◽  
Entrepreneurial University ◽  
The Public ◽  
The World ◽  
Industry Relationship ◽  
The University ◽  
The Relationship ◽  
University Industry

The economic and political changes in the world, from the 1970s, changed the political education of the Public Institutions of Higher Education in the world. The direction of these changes was clear: the university approachedthe market and the company and created interaction mechanisms that did not exist. The article therefore reviews the academic literature that interprets the relationship between university and market/company from two perspectives: approaches that positively position of interactions, exposing their motivations, interests and forms of interaction, especially the notions on Knowledge Economy and Entrepreneurial University; approaches that observe this interaction critically and reflectively, exposing the problems of interaction, its negative aspects and the reflection of the true role of the public university from the perspective of Academic Capitalism.

scholarly journals Beyond the academic’s dilemma: Transdisciplinary and existential perspectives of re-enchantment

2015 ◽  
Vol 11 (2) ◽  
Author(s):  
Rennie Naidoo
Keyword(s):  
Analytical Framework ◽  
Dialectical Tensions ◽  
Dialectical Approach ◽  
Sustainable Future ◽  
The World ◽  
The Subject ◽  
The University

The purpose of this article is to stimulate debate about the developing paradoxes and dilemmas facing the university academic. This article argues that academics are increasingly being steeped in an inauthentic existence due, at least partly to, egocentrism and sociocentrism. A modest transdisciplinary- existential analytical framework is applied as an intellectual method to reflect on the prevailing monological perspectives stifling the role of academics, in working towards building a more sustainable future. Using concepts such as the subject, facticity and transcendence, the article investigates the dialectical tensions between some of these monological perspectives and proposes avenues to create new possibilities to progress the role of the academic. The article argues that the multilogical perspectives of transdisciplinary thinking and the empowering perspectives of existential thinking can provide academics with the necessary conceptual tools to transcend egocentrism and sociocentrism. While it is likely that new contradictions will emerge as a result of this synthesis, open-minded academics are urged to ignite their imaginative powers and take up the challenge of creating and acting on new possibilities. A transdisciplinary-existential dialectical approach can provide a richer understanding of present dilemmas in academia and the world, and suggest more satisfying paths to a sustainable future.

Higher Education, Social Welfare, and Corruption

2019 ◽  
pp. 54-78
Author(s):  
Marlene M. Mendoza-Macías
Keyword(s):  
Higher Education ◽  
Human Development ◽  
Wealth Distribution ◽  
Sustainable Human Development ◽  
The Social ◽  
The World ◽  
Primary Focus ◽  
The University ◽  
Social Management

The world is facing multiple changes and challenges; the environment shows inequalities, poverty, and corruption. Ecuador is not the exception. The man is declared the primary focus of the Ecuadorian Constitution to meet such changes. The objective of decreasing poverty, improving wealth distribution, and contributing to sustainable human development is unavoidable. In that context, the university has the pivotal role in generating interaction with society and its reality, to train professionals social and humanly responsible towards such facts, to promote the social management of knowledge from different action fields. The goal of this chapter is to specify the role of higher education institutions (HEIs) in a society where they take part, to draw up social responsibility of universities in Guayaquil and the challenges they face, as well as actions that contribute to the eradication of corruption and greater wellbeing of the society.

The Role of Emotions in Christian Thought and Behavior

2020 ◽  
pp. 131-166
Keyword(s):  
Emotional Reactions ◽  
The Third ◽  
The World ◽  
Christian Thought ◽  
And Behavior

In the scriptural analyses presented in earlier chapters, there were many references to the emotions of Jesus, his disciples, and other characters. It will be clear by the end of this chapter that emotions play an important role in Christian and un-Christian behavior. The first section explains what emotions are and why humans have them. The second section catalogs the emotions expressed by characters in the four Gospels. It is interesting to see how the emotions expressed by Jesus were different than those expressed by other characters and also what prompted emotional reactions in Jesus. The third section generalizes the role of emotions in Christian behavior beyond the cataloging of the second section. This chapter is crucial for understanding motivations to engage in certain kinds of Christian behaviors that will help solve major problems in the world.

appealed to the Queen on being besieged by the wild sense, especially in the concluding cantos, of leaving Irish (see Vi4.1n). In reading this ‘darke conceit’, an iron world to enter a golden one. But do these no one could have failed to recognize these allusions. ways lead to an end that triumphantly concludes the The second point is that Spenser’s fiction, when 1596 poem, or to an impasse of the poet’s imaginat-compared to historical fact, is far too economical ive powers? For some readers, Book VI relates to the with the truth: for example, England’s intervention earlier books as Shakespeare’s final romances relate in the Netherlands under Leicester is, as A.B. Gough to his earlier plays, a crowning and fulfilment, ‘a 1921:289 concludes, ‘entirely misrepresented’. It summing up and conclusion for the entire poem and would seem that historical events are treated from for Spenser’s poetic career’ (N. Frye 1963:70; cf. a perspective that is ‘far from univocally celebratory Tonkin 1972:11). For others, Spenser’s exclamation or optimistic’, as Gregory 2000:366 argues, or in of wonder on cataloguing the names of the waters what Sidney calls their ‘universal consideration’, i.e. that attend the marriage of the Thames and the what is imminent in them, namely, their apocalyptic Medway, ‘O what an endlesse worke haue I in hand, import, as Borris 1991:11–61 argues. The third | To count the seas abundant progeny’ (IV xii point, which is properly disturbing to many readers 1.1–2), indicates that the poem, like such sixteenth-in our most slaughterous age, especially since the century romances as Amadis of Gaul, could now go matter is still part of our imaginative experience as on for ever, at least until it used up all possible virtues Healy 1992:104–09 testifies, is that Talus’s slaughter and the poet’s life. As Nohrnberg 1976:656 aptly of Irena’s subjects is rendered too brutally real in notes, ‘we find ourselves experiencing not the allegorizing, and apparently justifying, Grey’s atrocit-romance of faith or chastity, but the romance of ies in subduing Irish rebels (see V xii 26–27n). Here romance itself ’. For still others, there is a decline: Spenser is a product of his age, as was the Speaker ‘the darkening of Spenser’s spirit’ is a motif in many of the House of Commons in 1580 in reporting studies of the book, agreeing with Lewis 1936:353 the massacre of Spanish soldiers at Smerwick: ‘The that ‘the poem begins with its loftiest and most Italians pulled out by the ears at Smirwick in solemn book and thence, after a gradual descent, Ireland, and cut to pieces by the notable Service of a sinks away into its loosest and most idyllic’; and with noble Captain and Valiant Souldiers’ (D’Ewes Neuse 1968:331 that ‘the dominant sense of Book 1682:286). As this historical matter relates to Book V, VI is one of disillusionment, of the disparity between it displays the slaughter that necessarily attends the the poet’s ideals and the reality he envisions’; or that triumph of justice, illustrating the truth of the common the return to pastoral signals the failure of chivalry in adage, summum ius, summa iniuria, even as Guyon’s Book V to achieve reform (see DeNeef 1982b). destruction of the Bower shows the triumph of tem-Certainly canto x provides the strong sense of an perance. This is justice; or, at best, what justice has ending. As I have suggested, ‘it is as difficult not to become, and what its executive power displayed in see the poet intruding himself into the poem, as it is that rottweiler, Talus, has become, in our worse than not to see Shakespeare in the role of Prospero with ‘stonie’ age as the world moves towards its ‘last the breaking of the pipe, the dissolving of the vision, ruinous decay’ (proem 2.2, 6.9). In doing so, Book and our awareness (but surely the poet’s too) that his V confirms the claim by Thrasymachus in Plato’s work is being rounded out’ (1961a:202). Republic: justice is the name given by those in power Defined as ‘doing gentle deedes with franke to keep their power. It is the one virtue in the poem delight’ (vii 1.2), courtesy is an encompassing virtue that cannot be exercised by itself but within the book in a poem that sets out to ‘sing of Knights and Ladies must be over-ruled by equity, circumvented by mercy, gentle deeds’ (I proem 1.5). As such, its flowering and, in the succeeding book, countered by courtesy. would fully ‘fashion a gentleman or noble person in vertuous and gentle discipline’ (Letter to Raleigh 8). Courtesy: Book VI

2014 ◽  
pp. 36-36
Keyword(s):  
Strong Sense ◽  
Executive Power ◽  
House Of Commons ◽  
Historical Events ◽  
The Third ◽  
The World ◽  
Historical Fact ◽  
The Common ◽  
The One

Knowledge from the Outside

2021 ◽  
pp. 40-79
Author(s):  
Hilary Kornblith
Keyword(s):  
The Third ◽  
Person Perspective ◽  
The World ◽  
Third Person ◽  
First Person Perspective ◽  
Third Person Perspective ◽  
The Third Person ◽  
Perceptual Systems ◽  
Obvious Source

Knowledge may be examined from the third-person perspective, as psychologists and sociologists do, or it may be examined from the first-person perspective, as each of us does when we reflect on what we ought to believe. This chapter takes the third-person perspective. One obvious source of knowledge is perception, and some general features of how our perceptual systems are able to pick up information about the world around us are highlighted. The role of the study of visual illusions in this research is an important focus of the chapter. Our ability to draw out the consequences of things we know by way of inference is another important source of knowledge, and some general features of how inference achieves its successes are discussed. Structural similarities between the ways in which perception works and the ways in which inference works are highlighted.

scholarly journals MicroRNAs and Apoptosis in Colorectal Cancer

2020 ◽  
Vol 21 (15) ◽  
pp. 5353 ◽  
Author(s):  
Hsiuying Wang
Keyword(s):  
Colorectal Cancer ◽  
Treatment Resistance ◽  
Therapeutic Resistance ◽  
Cancer Therapies ◽  
Malignant Cells ◽  
Apoptosis Induction ◽  
The Third ◽  
Anti Cancer ◽  
The World

Colorectal cancer (CRC) is the third leading cause of cancer death in the world, and its incidence is rising in developing countries. Treatment with 5-Fluorouracil (5-FU) is known to improve survival in CRC patients. Most anti-cancer therapies trigger apoptosis induction to eliminate malignant cells. However, de-regulated apoptotic signaling allows cancer cells to escape this signaling, leading to therapeutic resistance. Treatment resistance is a major challenge in the development of effective therapies. The microRNAs (miRNAs) play important roles in CRC treatment resistance and CRC progression and apoptosis. This review discusses the role of miRNAs in contributing to the promotion or inhibition of apoptosis in CRC and the role of miRNAs in modulating treatment resistance in CRC cells.

Developing Online Learning Portals in Low Bandwidth Communities

2011 ◽  
pp. 228-234
Author(s):  
Mae van der Merwe ◽  
Lorna Uden
Keyword(s):  
Relevant Information ◽  
Learning Processes ◽  
Web Based ◽  
Web Interfaces ◽  
Front End ◽  
Present Information ◽  
The World ◽  
The University ◽  
The Web

University portals are emerging all over the world. Portals have been perceived by many people as the technologies that are designed to enhance work and learning processes at university by making workflows simpler and information more readily available in a form in which it can be processed (Franklin, 2004). There are many benefits for having a portal in a university. First, the portal makes it easy for people to find university information targeted specifically at them. Instead of the user searching the Web for information, a person identifies himself or herself to the portal, and the portal brings all relevant information to that person. Secondly, the portal uses a single consistent Web-based front end to present information from a variety of back-end data sources. Although information about people is stored in many different databases at a university, the role of a portal is to put a consistent face to this information so that visitors do not have to deal with dozens of different Web interfaces to get their information. Usability is an important issue when designing the university portal. Principles from human computer interaction must be included in the design of portals.

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