Molecular biology and electrophysiology of neuronal nicotinic receptors of rat chromaffin cells

2003 ◽  
Vol 17 (11) ◽  
pp. 2313-2322 ◽  
Author(s):  
Silvia Di Angelantonio ◽  
Cosetta Matteoni ◽  
Elsa Fabbretti ◽  
Andrea Nistri
Keyword(s):  
Molecular Biology ◽  
Chromaffin Cells ◽  
Nicotinic Receptors ◽  
Neuronal Nicotinic Receptors

scholarly journals Differential Expression of α-Bungarotoxin-Sensitive Neuronal Nicotinic Receptors in Adrenergic Chromaffin Cells: A Role for Transcription Factor Egr-1

1997 ◽  
Vol 17 (17) ◽  
pp. 6554-6564 ◽  
Author(s):  
Manuel Criado ◽  
Eduardo Domı́nguez del Toro ◽  
Carmen Carrasco-Serrano ◽  
Frazer I. Smillie ◽  
José M. Juı́z ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Differential Expression ◽  
Chromaffin Cells ◽  
Nicotinic Receptors ◽  
Neuronal Nicotinic Receptors

scholarly journals The Ferrier Lecture 1998 The molecular biology of consciousness investigated with genetically modified mice

2006 ◽  
Vol 361 (1476) ◽  
pp. 2239-2259 ◽  
Author(s):  
Jean-Pierre Changeux
Keyword(s):  
Animal Model ◽  
Molecular Biology ◽  
Nicotinic Receptors ◽  
Genetically Modified ◽  
Building Blocks ◽  
Behavioural Flexibility ◽  
Global Integration ◽  
Neuronal Nicotinic Receptors ◽  
Minimal Form ◽  
Elementary Building

The question is raised of the relevance of experimental work with the mouse and some of its genetically modified individuals in the study of consciousness. Even if this species does not go far beyond the level of ‘minimal consciousness’, it may be a useful animal model to examine the elementary building blocks of consciousness using the methods of molecular biology jointly with investigations at the physiological and behavioural levels. These building blocks which are anticipated to be universally shared by higher organisms (from birds to humans) may include: (i) the access to multiple states of vigilance, like wakefulness, sleep, general anaesthesia, etc.; (ii) the capacity for global integration of several sensory and cognitive functions, together with behavioural flexibility resulting in what is referred to as exploratory behaviour, and possibly a minimal form of intentionality. In addition, the contribution of defined neuronal nicotinic receptors species to some of these processes is demonstrated and the data discussed within the framework of recent neurocomputational models for access to consciousness.

Recombinant extracellular domains of human neuronal nicotinic receptors: Preliminary studies on mutant forms for the improvement of solubility

2007 ◽  
Vol 39 (4-5) ◽  
pp. 259-263
Author(s):  
M. Zouridakis ◽  
P. Zisimopoulou ◽  
E. Eliopoulos ◽  
L. Jacobson ◽  
K. Poulas ◽  
...  
Keyword(s):  
Nicotinic Receptors ◽  
Neuronal Nicotinic Receptors ◽  
Extracellular Domains ◽  
Mutant Forms
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