Recovery of metabolites from natural deep eutectic solvent matrices by countercurrent separation

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
Y Liu ◽  
J Garzon ◽  
JB Friesen ◽  
DC Lankin ◽  
JB McAlpine ◽  
...  
Keyword(s):  
Deep Eutectic Solvent ◽  
Natural Deep Eutectic Solvent

scholarly journals Amino Acids as the Potential Co-Former for Co-Crystal Development: A Review

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3279
Author(s):  
Ilma Nugrahani ◽  
Maria Anabella Jessica
Keyword(s):  
Amino Acids ◽  
Physicochemical Properties ◽  
Deep Eutectic Solvent ◽  
Strong Interactions ◽  
Green Method ◽  
Pharmaceutical Ingredients ◽  
Gastrointestinal Fluid ◽  
Non Covalent Interactions ◽  
Natural Deep Eutectic Solvent ◽  
Covalent Interactions

Co-crystals are one of the most popular ways to modify the physicochemical properties of active pharmaceutical ingredients (API) without changing pharmacological activity through non-covalent interactions with one or more co-formers. A “green method” has recently prompted many researchers to develop solvent-free techniques or minimize solvents for arranging the eco-friendlier process of co-crystallization. Researchers have also been looking for less-risk co-formers that produce the desired API’s physicochemical properties. This review purposed to collect the report studies of amino acids as the safe co-former and explored their advantages. Structurally, amino acids are promising co-former candidates as they have functional groups that can form hydrogen bonds and increase stability through zwitterionic moieties, which support strong interactions. The co-crystals and deep eutectic solvent yielded from this natural compound have been proven to improve pharmaceutical performance. For example, l-glutamine could reduce the side effects of mesalamine through an acid-base stabilizing effect in the gastrointestinal fluid. In addition, some amino acids, especially l-proline, enhances API’s solubility and absorption in its natural deep eutectic solvent and co-crystals systems. Moreover, some ionic co-crystals of amino acids have also been designed to increase chiral resolution. Therefore, amino acids are safe potential co-formers, which are suitable for improving the physicochemical properties of API and prospective to be developed further in the dosage formula and solid-state syntheses.

Natural deep eutectic solvent (NADES): a strategy to improve the bioavailability of blueberry phenolic compounds in a ready-to-use extract

2021 ◽  
pp. 130370
Author(s):  
Dariane Trivisiol da Silva ◽  
Franciele Aline Smaniotto ◽  
Isabella Ferreira Costa ◽  
Julia Baranzelli ◽  
Aline Muller ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Deep Eutectic Solvent ◽  
Natural Deep Eutectic Solvent

scholarly journals Paving the Way to Food Grade Analytical Chemistry: Use of a Natural Deep Eutectic Solvent to Determine Total Hydroxytyrosol and Tyrosol in Extra Virgin Olive Oils

Foods ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 677
Author(s):  
Vito Michele Paradiso ◽  
Francesco Longobardi ◽  
Stefania Fortunato ◽  
Pasqua Rotondi ◽  
Maria Bellumori ◽  
...  
Keyword(s):  
Analytical Chemistry ◽  
Acid Hydrolysis ◽  
Virgin Olive Oil ◽  
Deep Eutectic Solvent ◽  
Spectrophotometric Analysis ◽  
Health Claim ◽  
Food Grade ◽  
Olive Oils ◽  
Natural Deep Eutectic Solvent ◽  
The Way

Extra virgin olive oil (EVOO) is well known for containing relevant amounts of healthy phenolic compounds. The European Food Safety Authority (EFSA) allowed a health claim for labelling olive oils containing a minimum amount of hydroxytyrosol (OHTyr) and its derivatives, including tyrosol (Tyr). Therefore, harmonized and standardized analytical protocols are required in support of an effective application of the health claim. Acid hydrolysis performed after extraction and before chromatographic analysis has been shown to be a feasible approach. Nevertheless, other fast, green, and easy methods could be useful for on-site screening and monitoring applications. In the present research, a natural deep eutectic solvent (NADES) composed of lactic acid and glucose was used to perform a liquid/liquid extraction on EVOO samples, followed by UV-spectrophotometric analysis. The spectral features of the extracts were related with the content of total OHTyr and Tyr, determined by the acid hydrolysis method. The second derivative of spectra allowed focusing on three single wavelengths (i.e., 299 nm, 290 nm, and 282 nm) significantly related with total OHTyr, total Tyr, and their sum, respectively. In particular, the sum of OHTyr and Tyr could be determined with a root mean square error of prediction of 29.5 mg kg−1, while the limits of quantitation and detection were respectively 11.8 and 4.9 mg kg−1. The proposed method, therefore, represents an easy screening tool, with the use of a green, food-derived solvent, and could be considered as an attempt to pave the way for food grade analytical chemistry.

Laser-engraved ammonia sensor integrating a natural deep eutectic solvent

2020 ◽  
Vol 157 ◽  
pp. 105067 ◽  
Author(s):  
Makenzie Reynolds ◽  
Lucas M. Duarte ◽  
Wendell K.T. Coltro ◽  
Maria Fernanda Silva ◽  
Federico J.V. Gomez ◽  
...  
Keyword(s):  
Deep Eutectic Solvent ◽  
Ammonia Sensor ◽  
Natural Deep Eutectic Solvent
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