scholarly journals Acute Fatty Liver of Pregnancy and its Differentiation from Other Liver Diseases in Pregnancy

2015 ◽  
Vol 75 (08) ◽  
pp. 844-847 ◽  
Author(s):  
J. Maier ◽  
E. Schalinski ◽  
C. Häberlein ◽  
U. Gottschalk ◽  
L. Hellmeyer
Keyword(s):  
Fatty Liver ◽  
Liver Diseases ◽  
Acute Fatty Liver ◽  
In Pregnancy

scholarly journals Fatal case of acute fatty liver of pregnancy

2020 ◽  
Vol 10 (1) ◽  
pp. 410
Author(s):  
Sarada Mamilla ◽  
Sandhya Rani ◽  
Gayathri . ◽  
Bhavana . ◽  
Ramya Bharghavi ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Fatty Liver ◽  
High Mortality ◽  
Disseminated Intravascular Coagulation ◽  
Fatal Case ◽  
Mortality And Morbidity ◽  
Intravascular Coagulation ◽  
Acute Fatty Liver ◽  
In Pregnancy

Acute fatty liver in pregnancy is a catstrophic condition with high mortality and morbidity. Delay in managing complications would result in fatality. We present a case of 22-year-old primi, who presented to us in labor with jaundice and later developed, disseminated intravascular coagulation, Vulval haematoma, reexploration, sepsis, ARDS and cardiac arrest and death.

P371 Case series of acute fatty liver in pregnancy and literature review

2009 ◽  
Vol 107 ◽  
pp. S520-S520
Author(s):  
A. Uku ◽  
G. Mohiyiddeen ◽  
M. Raghavan ◽  
J. Wynn ◽  
T. Onon
Keyword(s):  
Literature Review ◽  
Fatty Liver ◽  
Case Series ◽  
Acute Fatty Liver ◽  
In Pregnancy

scholarly journals Liver diseases unique to pregnancy

Medicina ◽  
2008 ◽  
Vol 44 (5) ◽  
pp. 337 ◽  
Author(s):  
Jūratė Kondrackienė ◽  
Limas Kupčinskas
Keyword(s):  
Fatty Liver ◽  
Liver Diseases ◽  
Hyperemesis Gravidarum ◽  
Correct Diagnosis ◽  
Late Pregnancy ◽  
First Trimester ◽  
Third Trimester ◽  
Liver Disorders ◽  
Elevated Liver Enzymes ◽  
Acute Fatty Liver

The aim of this review article is to improve knowledge of the liver disease in pregnancy. The article summarizes the results of own experience and the recent reviews of liver disorders unique to pregnancy. Abnormalities in liver tests occur in 3% of pregnancies with causes ranging from self-limiting to rapidly fatal. In Kaunas University of Medicine Hospital, a retrospective analysis disclosed a rate of 0.52% of liver diseases in 16252 pregnant women over a 5-year period. Several liver diseases occur only during pregnancy and are considered to be associated with the pregnant state. The liver disorders unique to pregnancy have characteristic clinical features and timing of onset. Hyperemesis gravidarum occurs in the first trimester, intrahepatic cholestasis of pregnancy in the second or third trimester, preeclampsia, HELLP (hemolysis, elevated liver enzymes, low platelet count) syndrome, and acute fatty liver of pregnancy usually in the third trimester. The disorders of late pregnancy – preeclampsia, HELLP syndrome, and acute fatty liver of pregnancy – may progress to severe liver dysfunction. The correct diagnosis is critical, as any delay can result in morbidity or mortality of both the mother and fetus. Early delivery and advances in supportive management are the only available option for improving the prognosis.

Liver and endocrine diseases in pregnancy

2020 ◽  
pp. 295-305
Author(s):  
Catherine Williamson
Keyword(s):  
Fatty Liver ◽  
Rare Diseases ◽  
Adverse Outcomes ◽  
Reproductive Age ◽  
Endocrine Glands ◽  
Autoimmune Hypothyroidism ◽  
Endocrine Diseases ◽  
Acute Fatty Liver ◽  
Specific Disorders ◽  
In Pregnancy

Liver and endocrine diseases are sufficiently common in pregnancy that the majority of obstetricians will manage them regularly. They range from common disorders such as autoimmune hypothyroidism to rare diseases such as acute fatty liver of pregnancy. The liver and endocrine glands play important roles in homeostasis and metabolism, and abnormalities in their functioning can result in adverse outcomes for pregnant women and their children. This chapter describes the presentation and management of pregnancy-specific disorders of the liver and endocrine glands, and also focuses on the commoner disorders of these organs that can occur in women of reproductive age, and therefore which may also have an impact on pregnancy.

Antepartum Complications of Pregnancy

2018 ◽  
Author(s):  
Gaea Moore
Keyword(s):  
Cardiac Arrest ◽  
Fatty Liver ◽  
Multidisciplinary Care ◽  
Multidisciplinary Care Team ◽  
Perimortem Cesarean Section ◽  
Acute Fatty Liver ◽  
Pregnant State ◽  
Antepartum Complications ◽  
In Pregnancy

Pregnancy presents unique considerations and challenges to the critical care provider, including the physiologic adaptations to the pregnant state, recruitment and collaboration with a multidisciplinary care team, determination of fetal status, preparing for and managing cardiac arrest in pregnancy, and evaluation and management of diseases unique to pregnancy (including preeclampsia and acute fatty liver of pregnancy). This review contains 48 references, and 4 tables. Key words: acute fatty liver of pregnancy, maternal cardiac arrest, perimortem cesarean section, preeclampsia, pregnancy

scholarly journals The association between acute fatty liver disease and nitric oxide during malaria in pregnancy

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Mamoru Niikura ◽  
Toshiyuki Fukutomi ◽  
Shoichiro Mineo ◽  
Jiro Mitobe ◽  
Fumie Kobayashi
Keyword(s):  
Nitric Oxide ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Infiltration ◽  
Malaria In Pregnancy ◽  
Pregnant Mice ◽  
Acute Fatty Liver ◽  
Ifn Γ ◽  
In Pregnancy

Abstract Background Liver disease is a common feature of malaria in pregnancy, but its pathogenesis remains unclear. Methods To understand the pathogenesis of liver disease during malaria in pregnancy, comparative proteomic analysis of the liver in a mouse model of malaria in pregnancy was performed. Results Decreased levels of mitochondrial and peroxisomal proteins were observed in the livers of pregnant mice infected with the lethal rodent malaria parasite Plasmodium berghei strain NK65. By contrast, increased levels of perilipin-2, amyloid A-1, and interferon (IFN)-γ signalling pathway-related proteins were observed in the livers of infected pregnant mice, suggesting that IFN-γ signalling may contribute to the development of liver disease during malaria in pregnancy. IFN-γ signalling is a potential trigger of inducible nitric oxide synthase (iNOS) expression. Liver disease associated with microvesicular fatty infiltration and elevated liver enzymes in pregnant wild-type mice infected with malaria parasites was improved by iNOS deficiency. Conclusions In this study, a causative role of iNOS in liver disease associated with microvesicular fatty infiltration during malaria in pregnancy was demonstrated. These findings provide important insight for understanding the role of iNOS-mediated metabolic responses and the pathogenesis of high-risk liver diseases in pregnancy, such as acute fatty liver.

scholarly journals Factors Determining the Intensive Care Need in Help Syndrome & AFLP in Pregnancy

2021 ◽  
Vol 6 (2) ◽  
pp. 1-5
Author(s):  
Aydin Atis Alev ◽  
Keyword(s):  
Intensive Care ◽  
Fatty Liver ◽  
Liver Enzyme ◽  
Elevated Liver Enzyme ◽  
Mortality And Morbidity ◽  
Factors Affecting ◽  
Acute Fatty Liver ◽  
In Pregnancy

To compare factors affecting mortality and morbidity in HELLP (Hemolysis, Elevated Liver Enzyme Levels, and Low Platelets) syndrome & AFLP (Acute fatty liver of pregnancy).

scholarly journals Pregnancy-related liver pathology: hyperemesis gravidarum, cholestatic hepatosis of pregnancy, preeclampsia/eclampsia, HELLP-syndrome, acute fatty liver of pregnancy

2021 ◽  
Vol 1 ◽  
pp. 7-16
Author(s):  
О.V. Golyanovskiy ◽  
N.E.  Geints ◽  
V.V.  Mekhedko ◽  
S.V.  Frolov
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Pregnant Women ◽  
Liver Dysfunction ◽  
Hellp Syndrome ◽  
Liver Diseases ◽  
Hyperemesis Gravidarum ◽  
Late Pregnancy ◽  
Risk Groups ◽  
Acute Fatty Liver

Liver disease associated with pregnancy affects up to 3% of women and is a common cause of dysfunction during pregnancy. Severe liver dysfunction is associated with high rates of maternal and infant morbidity and mortality.Therefore, it is important to know about liver diseases the woman suffered before pregnancy in order to adequately manage the pregnancy and reduce the number of complications during delivery. Research and recent advances in medicine tend to improve the consequences, but so far they have not shown significant reduction of the maternal and perinatal morbidity rates against the background of this pathology. Liver diseases that are characteristic for pregnancy can be classified into those of early pregnancy (hyperemesis gravidarum) and those of late pregnancy (preeclampsia/eclampsia, intrahepatic cholestasis of pregnant women; hemolysis, increased activity of liver enzymes) HELLP-syndrome, acute fatty liver disease of pregnant women - AFLP, liver rupture / infarction).The results of modern studies used in the practice of medical care for pregnant women with concomitant pathology have significantly improved the pregnancy and delivery outcomes, but the number of complications among the mother and the fetus is still high. In this article, we offer an overview of liver diseases complicated by pregnancy with a detailed presentation of their aetiology, pathogenesis, diagnosis, and treatment. The risk groups of pregnant women with the potential possibility of liver dysfunction development have also been identified.

scholarly journals Death due to acute fatty liver in pregnancy

2014 ◽  
Vol 1 (2) ◽  
pp. 42
Author(s):  
M Vidanapathirana ◽  
HAM Hettiarachchi ◽  
KR Munasinghe
Keyword(s):  
Fatty Liver ◽  
Acute Fatty Liver ◽  
In Pregnancy
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