Liver and endocrine diseases in pregnancy

2020 ◽  
pp. 295-305
Author(s):  
Catherine Williamson
Keyword(s):  
Fatty Liver ◽  
Rare Diseases ◽  
Adverse Outcomes ◽  
Reproductive Age ◽  
Endocrine Glands ◽  
Autoimmune Hypothyroidism ◽  
Endocrine Diseases ◽  
Acute Fatty Liver ◽  
Specific Disorders ◽  
In Pregnancy

Liver and endocrine diseases are sufficiently common in pregnancy that the majority of obstetricians will manage them regularly. They range from common disorders such as autoimmune hypothyroidism to rare diseases such as acute fatty liver of pregnancy. The liver and endocrine glands play important roles in homeostasis and metabolism, and abnormalities in their functioning can result in adverse outcomes for pregnant women and their children. This chapter describes the presentation and management of pregnancy-specific disorders of the liver and endocrine glands, and also focuses on the commoner disorders of these organs that can occur in women of reproductive age, and therefore which may also have an impact on pregnancy.

scholarly journals Acute Fatty Liver of Pregnancy and its Differentiation from Other Liver Diseases in Pregnancy

2015 ◽  
Vol 75 (08) ◽  
pp. 844-847 ◽  
Author(s):  
J. Maier ◽  
E. Schalinski ◽  
C. Häberlein ◽  
U. Gottschalk ◽  
L. Hellmeyer
Keyword(s):  
Fatty Liver ◽  
Liver Diseases ◽  
Acute Fatty Liver ◽  
In Pregnancy

scholarly journals Fatal case of acute fatty liver of pregnancy

2020 ◽  
Vol 10 (1) ◽  
pp. 410
Author(s):  
Sarada Mamilla ◽  
Sandhya Rani ◽  
Gayathri . ◽  
Bhavana . ◽  
Ramya Bharghavi ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Fatty Liver ◽  
High Mortality ◽  
Disseminated Intravascular Coagulation ◽  
Fatal Case ◽  
Mortality And Morbidity ◽  
Intravascular Coagulation ◽  
Acute Fatty Liver ◽  
In Pregnancy

Acute fatty liver in pregnancy is a catstrophic condition with high mortality and morbidity. Delay in managing complications would result in fatality. We present a case of 22-year-old primi, who presented to us in labor with jaundice and later developed, disseminated intravascular coagulation, Vulval haematoma, reexploration, sepsis, ARDS and cardiac arrest and death.

P371 Case series of acute fatty liver in pregnancy and literature review

2009 ◽  
Vol 107 ◽  
pp. S520-S520
Author(s):  
A. Uku ◽  
G. Mohiyiddeen ◽  
M. Raghavan ◽  
J. Wynn ◽  
T. Onon
Keyword(s):  
Literature Review ◽  
Fatty Liver ◽  
Case Series ◽  
Acute Fatty Liver ◽  
In Pregnancy

Antepartum Complications of Pregnancy

2018 ◽  
Author(s):  
Gaea Moore
Keyword(s):  
Cardiac Arrest ◽  
Fatty Liver ◽  
Multidisciplinary Care ◽  
Multidisciplinary Care Team ◽  
Perimortem Cesarean Section ◽  
Acute Fatty Liver ◽  
Pregnant State ◽  
Antepartum Complications ◽  
In Pregnancy

Pregnancy presents unique considerations and challenges to the critical care provider, including the physiologic adaptations to the pregnant state, recruitment and collaboration with a multidisciplinary care team, determination of fetal status, preparing for and managing cardiac arrest in pregnancy, and evaluation and management of diseases unique to pregnancy (including preeclampsia and acute fatty liver of pregnancy). This review contains 48 references, and 4 tables. Key words: acute fatty liver of pregnancy, maternal cardiac arrest, perimortem cesarean section, preeclampsia, pregnancy

scholarly journals The association between acute fatty liver disease and nitric oxide during malaria in pregnancy

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Mamoru Niikura ◽  
Toshiyuki Fukutomi ◽  
Shoichiro Mineo ◽  
Jiro Mitobe ◽  
Fumie Kobayashi
Keyword(s):  
Nitric Oxide ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Infiltration ◽  
Malaria In Pregnancy ◽  
Pregnant Mice ◽  
Acute Fatty Liver ◽  
Ifn Γ ◽  
In Pregnancy

Abstract Background Liver disease is a common feature of malaria in pregnancy, but its pathogenesis remains unclear. Methods To understand the pathogenesis of liver disease during malaria in pregnancy, comparative proteomic analysis of the liver in a mouse model of malaria in pregnancy was performed. Results Decreased levels of mitochondrial and peroxisomal proteins were observed in the livers of pregnant mice infected with the lethal rodent malaria parasite Plasmodium berghei strain NK65. By contrast, increased levels of perilipin-2, amyloid A-1, and interferon (IFN)-γ signalling pathway-related proteins were observed in the livers of infected pregnant mice, suggesting that IFN-γ signalling may contribute to the development of liver disease during malaria in pregnancy. IFN-γ signalling is a potential trigger of inducible nitric oxide synthase (iNOS) expression. Liver disease associated with microvesicular fatty infiltration and elevated liver enzymes in pregnant wild-type mice infected with malaria parasites was improved by iNOS deficiency. Conclusions In this study, a causative role of iNOS in liver disease associated with microvesicular fatty infiltration during malaria in pregnancy was demonstrated. These findings provide important insight for understanding the role of iNOS-mediated metabolic responses and the pathogenesis of high-risk liver diseases in pregnancy, such as acute fatty liver.

scholarly journals Factors Determining the Intensive Care Need in Help Syndrome & AFLP in Pregnancy

2021 ◽  
Vol 6 (2) ◽  
pp. 1-5
Author(s):  
Aydin Atis Alev ◽  
Keyword(s):  
Intensive Care ◽  
Fatty Liver ◽  
Liver Enzyme ◽  
Elevated Liver Enzyme ◽  
Mortality And Morbidity ◽  
Factors Affecting ◽  
Acute Fatty Liver ◽  
In Pregnancy

To compare factors affecting mortality and morbidity in HELLP (Hemolysis, Elevated Liver Enzyme Levels, and Low Platelets) syndrome & AFLP (Acute fatty liver of pregnancy).

scholarly journals Death due to acute fatty liver in pregnancy

2014 ◽  
Vol 1 (2) ◽  
pp. 42
Author(s):  
M Vidanapathirana ◽  
HAM Hettiarachchi ◽  
KR Munasinghe
Keyword(s):  
Fatty Liver ◽  
Acute Fatty Liver ◽  
In Pregnancy

Acute Fatty Liver of Pregnancy From 18 Weeks’ Gestation

Hepatology ◽  
2020 ◽  
Vol 71 (6) ◽  
pp. 2167-2169 ◽  
Author(s):  
Mimi Wong ◽  
Frances Hills ◽  
Katrina Vogler ◽  
Ibrahim Zardawi ◽  
Nirjhar Nandi
Keyword(s):  
Fatty Liver ◽  
Acute Fatty Liver

scholarly journals High burden of anemia among pregnant women in Tanzania: a call to address its determinants

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Bruno F. Sunguya ◽  
Yue Ge ◽  
Linda Mlunde ◽  
Rose Mpembeni ◽  
Germana Leyna ◽  
...  
Keyword(s):  
Food Insecurity ◽  
Pregnant Women ◽  
Reproductive Age ◽  
Gis Mapping ◽  
Demographic And Health Surveys ◽  
Health Coverage ◽  
Nutritional Knowledge ◽  
Women Of Reproductive Age ◽  
Anemia In Pregnancy ◽  
In Pregnancy

Abstract Background Anemia in pregnancy is behind a significant burden of maternal mortality and poor birth outcomes globally. Efforts to address it need evidence on trends and its pertinent factors as they vary from one area to another. Methods We pooled data of 23,203 women of reproductive age whose hemoglobin levels were measured from two Tanzania Demographic and Health Surveys (TDHS). Of them, 2,194 women were pregnant. Analyses employed descriptive analyses to determine the burden of anemia, its characteristics, and severity; GIS mapping to determine the regional changes of anemia between 2005 and 2015; and logistic regression to determine the remaining determinants of anemia among pregnant women using Stata 15. Results The burden of anemia among pregnant women in Tanzania has remained unprecedently high, and varies between regions. There was no significant decline of anemia in general between the two periods after adjusting for individual, households, reproductive, and child characteristics [AOR = 0.964, 95% CI = 0.774–1.202, p = 0.747). Anemia is currently prevalent in 57% of pregnant women in Tanzania. The prevalence is more likely to be higher among women aged 15–19 years than those aged between 20–34 years. It is more likely to be prevalent among those within large families, with no formal education, food insecurity, lack of health insurance, had no antimalaria during pregnancy, and had low frequency of ANC attendance. On the other hand, delivery in a health facility may be potentially protective against anemia. Conclusions Anemia in pregnancy remained persistently high and prevalent among 57% of pregnant women in Tanzania. Efforts to address anemia are crucial and need to be focused in regions with increasing burden of anemia among pregnant women. It is imperative to address important risk factors such as food insecurity, strengthening universal health coverage, empowering women of reproductive age with education and especially nutritional knowledge and advocating for early antenatal booking, attendance, and facility delivery.

Sign in / Sign up

Export Citation Format

Share Document