Development and validation of a simple classification system for in vivo diagnosis of colorectal polyps using the newly introduced Optical Enhancement (OE) technology

2016 ◽  
Vol 54 (08) ◽  
Author(s):  
H Neumann ◽  
H Albrecht ◽  
S Löffler ◽  
M Vieth ◽  
T Rath ◽  
...  
Keyword(s):  
Classification System ◽  
Colorectal Polyps ◽  
Simple Classification ◽  
In Vivo Diagnosis ◽  
Development And Validation

Validation of a Simple Classification System for Endoscopic Diagnosis of Small Colorectal Polyps Using Narrow-Band Imaging

2012 ◽  
Vol 143 (3) ◽  
pp. 599-607.e1 ◽  
Author(s):  
David G. Hewett ◽  
Tonya Kaltenbach ◽  
Yasushi Sano ◽  
Shinji Tanaka ◽  
Brian P. Saunders ◽  
...  
Keyword(s):  
Classification System ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Colorectal Polyps ◽  
Endoscopic Diagnosis ◽  
Simple Classification

scholarly journals Sa1965 DEVELOPMENT AND VALIDATION OF A NEW CLASSIFICATION FOR IN VIVO DIAGNOSIS OF DUODENAL EPITHELIAL TUMORS WITH CONFOCAL LASER ENDOMICROSCOPY

2018 ◽  
Vol 87 (6) ◽  
pp. AB268-AB269
Author(s):  
Tomomitsu Tahara ◽  
Noriyuki Horiguchi ◽  
Masaaki Okubo ◽  
Hyuga Yamada ◽  
Tomohiko Kawamura ◽  
...  
Keyword(s):  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
New Classification ◽  
Epithelial Tumors ◽  
In Vivo Diagnosis ◽  
Development And Validation

In Vivo Diagnosis of Colorectal Polyps by GI Endoscopists Using HD Narrow-Band Imaging

2014 ◽  
Vol 109 ◽  
pp. S619 ◽  
Author(s):  
Jason Rocha ◽  
Shuko Lee ◽  
Lawrence Siegel ◽  
Neha Mathur ◽  
Suneal Agarwal ◽  
...  
Keyword(s):  
Narrow Band ◽  
Narrow Band Imaging ◽  
Colorectal Polyps ◽  
In Vivo Diagnosis

scholarly journals Aptamer Applications in Emerging Viral Diseases

2021 ◽  
Vol 14 (7) ◽  
pp. 622
Author(s):  
Arne Krüger ◽  
Ana Paula de Jesus Santos ◽  
Vanessa de Sá ◽  
Henning Ulrich ◽  
Carsten Wrenger
Keyword(s):  
Virus Assembly ◽  
Viral Diseases ◽  
Tissue Penetration ◽  
Rna Molecules ◽  
Viral Particles ◽  
Pharmacokinetic Properties ◽  
Oligonucleotide Library ◽  
In Vivo Diagnosis ◽  
Emerging Viral Diseases

Aptamers are single-stranded DNA or RNA molecules which are submitted to a process denominated SELEX. SELEX uses reiterative screening of a random oligonucleotide library to identify high-affinity binders to a chosen target, which may be a peptide, protein, or entire cells or viral particles. Aptamers can rival antibodies in target recognition, and benefit from their non-proteic nature, ease of modification, increased stability, and pharmacokinetic properties. This turns them into ideal candidates for diagnostic as well as therapeutic applications. Here, we review the recent accomplishments in the development of aptamers targeting emerging viral diseases, with emphasis on recent findings of aptamers binding to coronaviruses. We focus on aptamer development for diagnosis, including biosensors, in addition to aptamer modifications for stabilization in body fluids and tissue penetration. Such aptamers are aimed at in vivo diagnosis and treatment, such as quantification of viral load and blocking host cell invasion, virus assembly, or replication, respectively. Although there are currently no in vivo applications of aptamers in combating viral diseases, such strategies are promising for therapy development in the future.

scholarly journals ICH Guideline for Biopharmaceutics Classification System-Based Biowaiver (M9): Toward Harmonization in Latin American Countries

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 363
Author(s):  
Claudia Miranda ◽  
Alexis Aceituno ◽  
Mirna Fernández ◽  
Gustavo Mendes ◽  
Yanina Rodríguez ◽  
...  
Keyword(s):  
Latin American ◽  
Classification System ◽  
Biopharmaceutics Classification System ◽  
In Vitro Dissolution ◽  
Ich Guidelines ◽  
Latin American Region ◽  
Regulatory Guidelines ◽  
Biopharmaceutics Classification

The biopharmaceutical classification system (BCS) is a very important tool to replace the traditional in vivo bioequivalence studies with in vitro dissolution assays during multisource product development. This paper compares the most recent harmonized guideline for biowaivers based on the biopharmaceutics classification system and the BCS regulatory guidelines in Latin America and analyzes the current BCS regulatory requirements and the perspective of the harmonization in the region to develop safe and effective multisource products. Differences and similarities between the official and publicly available BCS guidelines of several Latin American regulatory authorities and the new ICH harmonization guideline were identified and compared. Only Chile, Brazil, Colombia, and Argentina have a more comprehensive BCS guideline, which includes solubility, permeability, and dissolution requirements. Although their regulatory documents have many similarities with the ICH guidelines, there are still major differences in their interpretation and application. This situation is an obstacle to the successful development of safe and effective multisource products in the Latin American region, not only to improve their access to patients at a reasonable cost, but also to develop BCS biowaiver studies that fulfill the quality standards of regulators in developed and emerging markets.

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