EARLY DIAGNOSIS IS ASSOCIATED WITH IMPROVED CLINICAL OUTCOME IN BENIGN ESOPHAGEAL PERFORATIONS: AN INDIVIDUAL PATIENT DATA META-ANALYSIS

2019 ◽  
Author(s):  
B Vermeulen ◽  
B van der Leeden ◽  
C Rosman ◽  
P Siersema
Keyword(s):  
Early Diagnosis ◽  
Clinical Outcome ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Patient Data ◽  
Esophageal Perforations ◽  
Benign Esophageal Perforations

scholarly journals Serum Mesothelin for Diagnosing Malignant Pleural Mesothelioma: An Individual Patient Data Meta-Analysis

2012 ◽  
Vol 30 (13) ◽  
pp. 1541-1549 ◽  
Author(s):  
Kevin Hollevoet ◽  
Johannes B. Reitsma ◽  
Jenette Creaney ◽  
Bogdan D. Grigoriu ◽  
Bruce W. Robinson ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Diagnostic Accuracy ◽  
Malignant Pleural Mesothelioma ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Patient Data ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Pleural Mesothelioma ◽  
Histologic Subtype

Purpose Mesothelin is currently considered the best available serum biomarker of malignant pleural mesothelioma. To examine the diagnostic accuracy and use of serum mesothelin in early diagnosis, we performed an individual patient data (IPD) meta-analysis. Methods The literature search identified 16 diagnostic studies of serum mesothelin, measured with the Mesomark enzyme-linked immunosorbent assay. IPD of 4,491 individuals were collected, including several control groups and 1,026 patients with malignant pleural mesothelioma. Mesothelin levels were standardized for between-study differences and age, after which the diagnostic accuracy and the factors affecting it were examined with receiver operating characteristic (ROC) regression analysis. Results At a common diagnostic threshold of 2.00 nmol/L, the sensitivities and specificities of mesothelin in the different studies ranged widely from 19% to 68% and 88% to 100%, respectively. This heterogeneity can be explained by differences in study population, because type of control group, mesothelioma stage, and histologic subtype significantly affected the diagnostic accuracy. The use of mesothelin in early diagnosis was evaluated by differentiating 217 patients with stage I or II epithelioid and biphasic mesothelioma from 1,612 symptomatic or high-risk controls. The resulting area under the ROC curve was 0.77 (95% CI, 0.73 to 0.81). At 95% specificity, mesothelin displayed a sensitivity of 32% (95% CI, 26% to 40%). Conclusion In patients suspected of having mesothelioma, a positive blood test for mesothelin at a high-specificity threshold is a strong incentive to urge further diagnostic steps. However, the poor sensitivity of mesothelin clearly limits its added value to early diagnosis and emphasizes the need for further biomarker research.

Mortality in Adults with MDR-TB and HIV by ART and TB Drug Use: Individual Patient Data Meta-Analysis

2020 ◽  
Author(s):  
Gregory Bisson ◽  
Mayara Bastos ◽  
Jonathon R. Campbell ◽  
Didi Bang ◽  
James C. Brust ◽  
...  
Keyword(s):  
Drug Use ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Patient Data ◽  
Mdr Tb

Sentinel Lymph Node Procedure in Colon Cancer: A Systematic Review and Meta-Analysis of Individual Patient Data

2020 ◽  
Author(s):  
Marjolein Ankersmit ◽  
Martijn W. Heymans ◽  
Otto Hoekstra ◽  
Stijn L. Vlek ◽  
Linda J. Schoonmade ◽  
...  
Keyword(s):  
Systematic Review ◽  
Colon Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Patient Data ◽  
Sentinel Lymph Node Procedure
Sign in / Sign up

Export Citation Format

Share Document