Automated Monitoring of Platelet Aggregation in Multiple Samples of whole Blood

1975 ◽  
Author(s):  
N. Clarke ◽  
V. McCabe

Whole blood may be first agitated in a circular transparent rotor chamber, and then rotated continuously to produce plasma/red cell separation for monitoring. The rotor is driven by a low inertia, printed circuit d.c. motor (108 Watt) which is automatically controlled. The pattern of rotation is determined by a signal generator which provides various waveforms at adjustable frequencies and also at fixed speeds.By segmenting the rotor into multiple cuvettes (Vol = 0.4 ml) it is possible to monitor the platelet concentration, after agitation, as each cuvette spins through the stationary optical system. This consists of a light-emitting diode (peak: 900 nm), pulsed at 10 kHz in order to eliminate ambient light effects, and a photodetector with a built-in amplifier, fed to an amplifying circuit which eliminates other signals. An electronic circuit permits selection of the signal from each cuvette on a direct reading meter. Cuvette No. 1 is identified by a photocell-detector trigger.Platelet-free plasma is about zero O. D. in the infra red with respect to a water blank, and with attention to specific criteria such as optical geometry and light path, platelet concentration may be accurately determined.

Author(s):  
Jun-Xian Fu ◽  
Shukri Souri ◽  
James S. Harris

Abstract Temperature and humidity dependent reliability analysis was performed based on a case study involving an indicator printed-circuit board with surface-mounted multiple-die red, green and blue light-emitting diode chips. Reported intermittent failures were investigated and the root cause was attributed to a non-optimized reflow process that resulted in micro-cracks and delaminations within the molding resin of the chips.


2012 ◽  
Vol 58 (1) ◽  
pp. 112-120 ◽  
Author(s):  
Y.V. Alexeev ◽  
E.V. Likhacheva ◽  
D.V. Tereshkin ◽  
G.V. Ponomarev ◽  
E.M. Mazur

Accumulation of photosensibilisators - derivatives of E6 chlorines ("Radachlorine", "Photoditazine", "Zelevsky's balsam") in the mucous membrane and selection of most effective sources of emission have been investigated in 30 patients with rhinosinusitis and 10 with tonsillitis. As a source of emission we used light emitting diode (LED) matrix device "ACT" (wavelength approximately 405 nm (Sore band)) and a laser device LAHTA-"MILON"-ML500-SP (wavelength - 662 nm). Drug accumulation in the mucous membrane and changes of their concentrations after emission were evaluated by changes of fluorescence, measured with a LESA-01-BIOSPEC spectrometer. The percent of fluorescence decrease ranged from 50% to 92.7%. This suggests intensive disintegration of photosensibilisators, and consequently, high therapeutic activity of this method. Effectiveness of this method is also confirmed by clinical results.


1974 ◽  
Vol 20 (9) ◽  
pp. 1135-1137 ◽  
Author(s):  
R Fesler ◽  
Th Clerbaux

Abstract A small, easily-built photometer is described, in which a solid-state light-emitting diode is used as the light source and a phototransistor as the detector. The detector response is kept constant by modulating the diode intensity in proportion to the absorption characteristics of the sample being analyzed. Linearity and stability are good, even with turbid solutions (drift is <0.001 absorbance unit per hour). A typical application of this photometer is the continuous measurement of the percentage of oxyhemoglobin (0 to 100 %) in blood. For hemoglobin concentrations from 3 to 18 g/dl, the relation between oxyhemoglobin as estimated with this diode photometer and by a galvanic method (LEX-O2-CON) was: SO2LED = 0.993 SO2 % LEX + 0.69;r = 0.9975; n = 129; Syx = 1.59.


Author(s):  
Sang-Youl Lee ◽  
Eunduk Lee ◽  
Ji-Hyung Moon ◽  
Byoungjun Choi ◽  
Jeong-Tak Oh ◽  
...  

2013 ◽  
Vol 3 (2) ◽  
pp. 41
Author(s):  
Andrea Marisi ◽  
Revantino Revantino

Perkembangan teknologi di bidang Solid State Lighting selama dekade terakhir membuat diversifikasi penggunaan Light Emitting Diode untuk pelayanan pencahayaan umum. Balai Besar Bahan dan Barang Teknik sejak tahun 2011 telah melakukan penelitian dan pengembangan lampu LED berbasis Surface Mounting Device (SMD) 5050. Pada perancangan Printed Circuit Board (PCB) untuk memasangkan LED-smd tersebut, dilakukan analisis dimensi geometrik yang optimal sehingga dapat memancarkan cahaya ke segala arah dan memberikan persepsi kecerahan yang lebih baik. Untuk perancangan PCB tersebut, dipilih 2 (dua) model berbentuk silinder dengan memperhatikan rasio antara tinggi dan diameter alas. Dari pendekatan sumber titik dan perhitungan eksitansi luminus, diperoleh bahwa model dengan rasio ≈ 1 menghasilkan persepsi lebih cerah terhadap visual manusia.Kata kunci : dimensi geometrik, pendekatan sumber titik, eksitansi luminus, persepsi kecerahan


2018 ◽  
Vol 51 (7-8) ◽  
pp. 293-303 ◽  
Author(s):  
Chao-Ching Ho ◽  
You-Min Chen ◽  
Po-Chieh Li

Background: In this study, a machine vision–based method was developed for automated in-process light-emitting diode chip mounting lines with position uncertainty. In order to place the tiny light-emitting diode chips on the pattern of a printed circuit board, a highly accurate mounting process is achieved with online feedback of the visual assistance. Methods: The system consists of a charge-coupled device camera, a six-axis robot arm, and a delta robot. The lighting system is a critical point for the in-process machine vision problem. Hence, designing the optimal lighting solution is one of the most difficult parts of a machine vision system, and several lighting techniques and experiments are examined in this study. In order to commence the mounting process, the light-emitting diode chip targets inside the camera field were identified and used to guide the delta robot to the grabbing zone based on the calibrated homography transformation. Efforts have been focused on the field of machine vision–based feature extraction of the chip pins and the holes on the printed circuit board. The correspondence of each other is determined by the position of the chip pins and the printed circuit board circuit pattern. The image acquisition is achieved directly online in real time. The image analysis algorithm must be sufficiently fast to follow the production rate. In order to compensate for the uncertainty of the light-emitting diode chip mounting process, a visual feedback strategy in conjunction with an uncertainty compensation strategy is employed. Results: Finally, the light-emitting diode chip was automatically grabbed and accurately placed at the desired positions. Conclusion: On-line and off-line experiments were conducted to investigate the performance of the vision system with respect to detecting and mounting light-emitting diode chips.


2019 ◽  
Vol 97 (2) ◽  
pp. 490-496
Author(s):  
Scott L. Wallen ◽  
Jaspreet Dhau ◽  
Robert Green ◽  
Laura B. Wemple ◽  
Troy Kelly ◽  
...  

2020 ◽  
pp. 147715352097693
Author(s):  
T Aderneuer ◽  
O Stefani ◽  
O Fernández ◽  
C Cajochen ◽  
R Ferrini

The growing awareness of the biological effects of electric light on humans has stimulated ample research. New research has been devoted to lighting solutions that dynamically change their colour to mimic spectral changes of daylight. However, in some situations, the visual properties of light must be preserved, such as when working under standardised lighting conditions to do colour correction in post-production. We have investigated the possibility to tune circadian effects using white lights that are spectrally different but nonetheless appear as a similar white tone. Our simulation results, for example, sets of light-emitting diodes, indicate that it is possible to modulate circadian light effects from 0.20 to 0.41 circadian stimulus by combining light-emitting diodes to create neutral white (4000 K) light. However, the results also show that the solutions combining single-colour light-emitting diodes leading to similar range between maximum and minimum circadian stimulus (ΔCS > 0.20) have a CRI below 80. Combining narrowband light-emitting diodes with a broadband white light-emitting diode improves the colour-rendering quality, and we show how far circadian light effects can be tuned according to common theoretical models. The aim is to maintain the natural cycle of melatonin levels as much as possible with high light stimulus in the morning and low light stimulus in the evening. Therefore, we show what maximum and minimum circadian effects are possible with a given set of light-emitting diodes.


2007 ◽  
Vol 32 (5) ◽  
pp. 443-450 ◽  
Author(s):  
M. G. Brackett ◽  
W. W. Brackett ◽  
W. D. Browning ◽  
F. A. Rueggeberg

Clinical Relevance The selection of light curing unit (quartz-tungsten-halogen or blue light-emitting diode), composite classification and shade have an influence on the amount of residual yellow after photocuring and, in some combinations, the color difference may be visually detectable.


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