Walmart store closures, especially in rural areas, seem to be continuing since the company is moving forward in serving its urban customers and investing heavily in its digital features and markets. If this scenario happens, then many townspeople in a rural area will lose their only Walmart store, which has been part of the town for decades. There are many studies on the impact of Walmart's entry and presence in towns. However, investigating the effects of Walmart when they leave small towns is still rare. For this reason, this study is focused on addressing the impact of Walmart store closures in small towns in Missouri. The purpose of this study is to identify factors affecting the residents' perception of and response toward the impact of Walmart's store closure in Rural Areas. Our conceptual framework is designed to assess household vulnerability and incorporate food insecurity factors to capture how vulnerability and resilience in rural communities change because of the closure of a Walmart store. This approach may help us better understand the linkages between community vulnerability and community resilience. Using a mixed-method design, we explored the residents' perceptions, opinions, and experiences regarding the closing of Walmart. Data from both the qualitative phase (observation, semi-structured interview, group discussion, and document analysis) and quantitative phase (community-based drop-off and pick-up surveys) of this study then mixed in the final analysis to provide a more detailed and complete description of the effect of Walmart store closures in rural Missouri. We found that people were overwhelmingly disappointed and angry when Walmart closed in their area in 2017. Most residents said they felt disappointed (46 percent) and angry (41 percent) about Walmart's decision. There was a change in households' attitudes and shopping habits after Walmart left these towns, including a significant decline (54.9 percent) in shopping frequency among residents who often shop at Walmart. Not having Wal sense of losing pride in being part of the town. When Caruthersville and Piedmont still had Walmart in town, it became the center of community for the surrounding towns and the entire county. The number of households that fall into vulnerability categories (very lowvulnerable, low-vulnerable, vulnerable, and very vulnerable) is calculated and obtained from Categorical Principal Component Analysis (CATPCA). The data showed that most households fell into a vulnerable (39.8 percent) and low-vulnerable situation (34.6 percent) after Walmart left and were able to cope with this stressor. Households in the neighboring towns (Patterson, Williamsville, and Greenville) that were 10-15 miles from Piedmont also had a high percentage of vulnerable groups (47.6 percent) and very vulnerable households (6.5 percent). Based on this study, the Walmart store's closure in Piedmont had a bigger impact on both the households within the host town and their neighboring towns. Our findings also confirmed that many residents in these areas rely on government assistance programs, especially SNAP (Supplemental Nutritional Assistance Program), the most extensive federal nutrition program in the U.S. About 43.7 percent of households in Caruthersville, 25.5 percent of households in Piedmont, and 24.4 percent of households in the neighboring town are SNAP recipients. These findings further prove that SNAP recipients and community food bank/pantry users were more sensitive to Walmart's store closure. While SNAP benefits provided valuable support to many households, the retail mobility -- increased proximity to small retailers and decreased proximity to many large ones (Walmart) -- would negatively affect townspeople. This study suggests that Policymakers and public health experts need to work closely to ensure healthier and more equitable food systems since small retailers may provide limited access to fresh and healthy foods. Future research can also evaluate the impact of existing small retailers - that authorized for SNAPof the rural community.