scholarly journals CEACAM1-4S, a cell-cell adhesion molecule, mediates apoptosis and reverts mammary carcinoma cells to a normal morphogenic phenotype in a 3D culture

2003 ◽  
Vol 100 (2) ◽  
pp. 521-526 ◽  
Author(s):  
J. Kirshner ◽  
C.-J. Chen ◽  
P. Liu ◽  
J. Huang ◽  
J. E. Shively
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Mammary Carcinoma ◽  
Cell Adhesion Molecule ◽  
3D Culture ◽  
Carcinoma Cells ◽  
A Cell ◽  
Mammary Carcinoma Cells ◽  
Cell Cell

scholarly journals Toxicodendron vernicifluum Stokes extract inhibits solid tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0241805
Author(s):  
Hyun Sook Lee ◽  
Jae In Jung ◽  
Kyeong-Hee Kim ◽  
Sang Jae Park ◽  
Eun Ji Kim
Keyword(s):  
Cell Adhesion ◽  
Plasminogen Activator ◽  
Lung Metastasis ◽  
Adhesion Molecule ◽  
Mammary Carcinoma ◽  
Cell Adhesion Molecule ◽  
Carcinoma Cells ◽  
Mammary Carcinoma Cells ◽  
Murine Mammary Carcinoma ◽  
Toxicodendron Vernicifluum

Toxicodendron vernicifluum Stokes has long been used as a food supplement and traditional herbal medicine in East Asia. We applied a new extraction method to produce Toxicodendron vernicifluum Stokes extract (TVSE), that doesn’t contain urushiol (an allergenic toxin) but dose have higher levels of some flavonoids such as fustin and fisetin. This study was conducted to investigate the anticancer effects of TVSE in an in vivo system. Fifty BALB/c mice were acclimated for one week and then injected with 4T1 murine mammary carcinoma cells in mammary fat pads. After 7 days, the mice were randomly divided into 5 groups, and orally administered with 0, 50, 100, 200 or 400 mg of TVSE/kg body weight (BW)/day for 20 days. TVSE reduced tumor volume and weight dose-dependently. The expression of Ki67 was significantly reduced and the number of TUNEL-positive apoptotic cells was significantly increased in the TVSE-treated group over 100 mg/kg BW/day. While tumor nodules were not found in the liver, but only in lungs, the number of tumor nodules was reduced in a dose-dependent manner in the TVSE treated groups compared to the control group. In breast tumors, expression of platelet endothelial cell adhesion molecule (PECAM-1) and vascular endothelial growth factor (VEGF) was reduced by TVSE treatment. TVSE treatment significantly suppressed mRNA expression in tumors of matrix metalloproteinase (MMP)-2, tissue inhibitor of metalloproteinase (TIMP)-1, urokinase-type plasminogen activator (uPA), intercellular adhesion molecule (ICAM)-1, and vascular cell adhesion molecule (VCAM)-1 while increasing plasminogen activator inhibitor (PAI)-1. These results suggest that TVSE is potentially beneficial for the suppression of breast cancer growth and its-associated lung metastasis.

Mutations of PVRL1, encoding a cell-cell adhesion molecule/herpesvirus receptor, in cleft lip/palate-ectodermal dysplasia

10.1038/78119 ◽  
2000 ◽  
Vol 25 (4) ◽  
pp. 427-430 ◽  
Author(s):  
Koji Suzuki ◽  
Diane Hu ◽  
Tania Bustos ◽  
Joel Zlotogora ◽  
Antonio Richieri-Costa ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Cleft Lip ◽  
Ectodermal Dysplasia ◽  
Cleft Lip Palate ◽  
A Cell ◽  
Cell Cell

767: N-Cadherinis Playing a Roleas a Cell-Cell Adhesion Molecule Under Impairedfunction of E-Cadherin and Cadherin-6 in Renal Cell Carcinoma

2004 ◽  
Vol 171 (4S) ◽  
pp. 203-204
Author(s):  
Toru Shimazui ◽  
Jack A. Schalken ◽  
Koji Kawai ◽  
Egbert Oosterwijk ◽  
Hideyuki Akaza
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Adhesion ◽  
Cell Carcinoma ◽  
Adhesion Molecule ◽  
Renal Cell ◽  
Cell Adhesion Molecule ◽  
A Cell ◽  
E Cadherin ◽  
Cell Cell

622: Von Hippel-Lindau Inactivation Downregulates the Cell-Cell Adhesion Molecule E Cadherin in Renal Cancer Cells

2005 ◽  
Vol 173 (4S) ◽  
pp. 170-170
Author(s):  
Maxine G. Tran ◽  
Miguel A. Esteban ◽  
Peter D. Hill ◽  
Ashish Chandra ◽  
Tim S. O'Brien ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Cancer Cells ◽  
Renal Cancer ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Von Hippel Lindau ◽  
E Cadherin ◽  
Cell Cell
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