scholarly journals Identification of Four Amino Acids in the Gastrin-releasing Peptide Receptor That Are Required for High Affinity Agonist Binding

1997 ◽  
Vol 272 (28) ◽  
pp. 17405-17409 ◽  
Author(s):  
Mark Akeson ◽  
Eduardo Sainz ◽  
Samuel A. Mantey ◽  
Robert T. Jensen ◽  
James F. Battey
Keyword(s):  
Amino Acids ◽  
Agonist Binding ◽  
Peptide Receptor ◽  
Gastrin Releasing Peptide ◽  
High Affinity

Identification of key amino acids in the gastrin-releasing peptide receptor (GRPR) responsible for high affinity binding of gastrin-releasing peptide (GRP)

2005 ◽  
Vol 69 (4) ◽  
pp. 579-593 ◽  
Author(s):  
Tomoo Nakagawa ◽  
Simon J. Hocart ◽  
Michael Schumann ◽  
Jose A. Tapia ◽  
Samuel A. Mantey ◽  
...  
Keyword(s):  
Amino Acids ◽  
Affinity Binding ◽  
High Affinity Binding ◽  
Peptide Receptor ◽  
Gastrin Releasing Peptide ◽  
High Affinity

scholarly journals Molecular Basis for Selectivity of High Affinity Peptide Antagonists for the Gastrin-releasing Peptide Receptor

2001 ◽  
Vol 276 (39) ◽  
pp. 36652-36663 ◽  
Author(s):  
Kenji Tokita ◽  
Tatsuro Katsuno ◽  
Simon J. Hocart ◽  
David H. Coy ◽  
Muriel Llinares ◽  
...  
Keyword(s):  
Molecular Basis ◽  
Peptide Receptor ◽  
Gastrin Releasing Peptide ◽  
High Affinity ◽  
Affinity Peptide

Molecular docking studies of tea (Thea sinensis Linn.) polyphenols inhibition pattern with Rat P-glycoprotein

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Babar Ali ◽  
Qazi Mohammad Sajid Jamal ◽  
Showkat R. Mir ◽  
Saiba Shams ◽  
Mohammad Amjad Kamal
Keyword(s):  
Amino Acids ◽  
Molecular Docking ◽  
Binding Energy ◽  
Oral Administration ◽  
Docking Studies ◽  
Vital Role ◽  
Glycoprotein P ◽  
High Affinity ◽  
P Glycoprotein ◽  
Inhibition Pattern

AbstractSince 3000 B.C., evergreen plant Thea sinensis (Theaceae) is used both as a social and medicinal beverage. Leaves of T. sinensis contain amino acids, vitamins, caffeine, polysaccharides and polyphenols. Most of the natural medicinal actions of tea are due to the availability and abundance of polyphenols mainly catechins. It has also been stated that some catechins were absorbed more rapidly than other compounds after the oral administration of tea and could increase the bio-enhancing activities of anticancer drugs by inhibiting P-glycoprotein (P-gp). The results of the molecular docking showed that polyphenols bind easily to the active P-gp site. All compounds exhibited fluctuating binding affinity ranged from −11.67 to −8.36 kcal/mol. Observed binding energy required for theaflavin to bind to P-gp was lowest (−11.67 kcal/mol). The obtained data that supports all the selected polyphenols inhibited P-gp and therefore may enhance the bioavailability of drugs. This study may play a vital role in finding hotspots in P-gp and eventually may be proved useful in designing compounds with high affinity and specificity to the protein.

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