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Published By Walter De Gruyter Gmbh

2365-659x, 2365-6581

2022 ◽  
Vol 0 (0) ◽  
Author(s):  
Abhijeet Singh ◽  
Pargat Singh ◽  
Mahendra Nath

Abstract Organic transformations using efficient, atom-economical, cost-effective and environmentally benign strategies for the construction of diversified molecules have attracted synthetic chemists worldwide in recent years. These processes often minimize the waste production and avoid the use of hazardous flammable organic solvents. Among various green protocols, the procedures using surfactant-based catalytic systems have received a considerable attention in organic synthesis. In this context, Bronsted acidic surfactants have emerged as efficient catalysts for various C–C, C–O, C–N and C–S bond forming reactions. Many of these reactions occur in water, as Bronsted acidic surfactants have a unique ability of creating hydrophobic pocket through micelle formation in aqueous medium and the substrate molecules react efficiently to afford the targeted products in good yields. In the past, Bronsted acidic surfactant combined catalysts successfully displayed their potential to accelerate the reaction rates of diverse organic transformations. This chapter presents a complete overview on Bronsted acidic surfactants catalyzed organic reactions to construct a variety of aromatic and heteroaromatic molecular frameworks.


2022 ◽  
Vol 0 (0) ◽  
Author(s):  
Prasanth Bhatt ◽  
Swamynathan Ganesan ◽  
Infant Santhose ◽  
Thirumurugan Durairaj

Abstract Phytoremediation is a process which effectively uses plants as a tool to remove, detoxify or immobilize contaminants. It has been an eco-friendly and cost-effective technique to clean contaminated environments. The contaminants from various sources have caused an irreversible damage to all the biotic factors in the biosphere. Bioremediation has become an indispensable strategy in reclaiming or rehabilitating the environment that was damaged by the contaminants. The process of bioremediation has been extensively used for the past few decades to neutralize toxic contaminants, but the results have not been satisfactory due to the lack of cost-effectiveness, production of byproducts that are toxic and requirement of large landscape. Phytoremediation helps in treating chemical pollutants on two broad categories namely, emerging organic pollutants (EOPs) and emerging inorganic pollutants (EIOPs) under in situ conditions. The EOPs are produced from pharmaceutical, chemical and synthetic polymer industries, which have potential to pollute water and soil environments. Similarly, EIOPs are generated during mining operations, transportations and industries involved in urban development. Among the EIOPs, it has been noticed that there is pollution due to heavy metals, radioactive waste production and electronic waste in urban centers. Moreover, in recent times phytoremediation has been recognized as a feasible method to treat biological contaminants. Since remediation of soil and water is very important to preserve natural habitats and ecosystems, it is necessary to devise new strategies in using plants as a tool for remediation. In this review, we focus on recent advancements in phytoremediation strategies that could be utilized to mitigate the adverse effects of emerging contaminants without affecting the environment.


2022 ◽  
Vol 0 (0) ◽  
Author(s):  
Sunil Kumar ◽  
Madhuri T. Patil ◽  
Deepak B. Salunke

Abstract Cancer weakens the immune system which fails to fight against the rapidly growing cells. Among the various types of cancers, prostate cancer (PCa) is causing greater number of deaths in men after lung cancer, demanding advancement to prevent, detect and treat PCa. Several small molecule heterocycles and few peptides are being used as oncological drugs targeting PCa. Heterocycles are playing crucial role in the development of novel cancer chemotherapeutics as well as immunotherapeutics. Indole skeleton, being a privileged structure has been extensively used for the discovery of novel anticancer agents and the application of indole derivatives against breast cancer is well documented. The present article highlights the usefulness of indole linked heterocyclic compounds as well as the fused indole derivatives against prostate cancer.


2022 ◽  
Vol 0 (0) ◽  
Author(s):  
Md Mosleh Uddin ◽  
Mark Mba Wright

Abstract Anaerobic digestion (AD) is a natural biochemical process that converts organic materials into combustible biogas. AD has been long practiced for agricultural and urban waste management; however, this process is getting more attention as an alternative energy source nowadays. Additionally, various biogas-derived value-added chemicals and transportation fuels are turning AD into a profitable biorefinery business model. Despite its numerous potentials, AD technologies still face challenges in conversion efficiency, process stability, product quality, and economic feasibility. Researchers have been devising various mechanisms to tackle these challenges. However, a widespread adoption of commercial-scale AD is yet to be visible. The development of AD technology requires a concerted effort of scientists from different backgrounds to ensure rapid expansion.


2022 ◽  
Vol 0 (0) ◽  
Author(s):  
Michael Barnard

Abstract People asserting that SMRs are the primary or only answer to energy generation either don’t know what they are talking about, are actively dissembling or are intentionally delaying climate action.


2022 ◽  
Vol 0 (0) ◽  
Author(s):  
Naresh Kumar ◽  
Nidhi Goel

Abstract Cancer, one of the key health problems globally, is a group of related diseases that share a number of characteristics primarily the uncontrolled growth and invasive to surrounding tissues. Chemotherapy is one of the ways for the treatment of cancer which uses one or more anticancer agents as per chemotherapy regimen. Limitations of most anticancer drugs due to a variety of reasons such as serious side effects, drug resistance, lack of sensitivity and efficacy etc. generate the necessity towards the designing of novel anticancer lead molecules. In this regard, the synthesis of biologically active heterocyclic molecules is an appealing research area. Among heterocyclic compounds, nitrogen containing heterocyclic molecules has fascinated tremendous consideration due to broad range of pharmaceutical activity. Imidazoles, extensively present in natural products as well as synthetic molecules, have two nitrogen atoms, and are five membered heterocyclic rings. Because of their countless physiological and pharmacological characteristics, medicinal chemists are enthused to design and synthesize new imidazole derivatives with improved pharmacodynamic and pharmacokinetic properties. The aim of this present chapter is to discuss the synthesis, chemistry, pharmacological activity, and scope of imidazole-based molecules in anticancer drug development. Finally, we have discussed the current challenges and future perspectives of imidazole-based derivatives in anticancer drug development.


2022 ◽  
Vol 0 (0) ◽  
Author(s):  
Susan Krumdieck

Abstract Consider a simple idea describing the time, space and relationship scales of survival. Engineering has been going along with the current paradigm that growth in wealth and material consumption can continue through innovation and technology development. The proposed survival continuum concept represents a new way to think about sustainability that has clear implications for influencing engineering projects in all fields. The argument for survival as the driver for adaptation is developed sequentially, building on theory, definition, examples and history. The key idea is that sustainability will be effectively addressed by a new engineering discipline furthering development of the field of safety engineering with longer time scale, broader space scale and more complex relationship scale. The implication is that the past 100-year development of safety engineering can be leveraged to fast-track the inclusion of sustainability risk management throughout the entire engineering profession. The conclusion is that a new, interdisciplinary field, Transition Engineering, is emerging as the way our society will achieve sustainability-safety through rapid reduction in fossil fuel use and reduction in detrimental social and environmental impacts of industrialization.


2022 ◽  
Vol 0 (0) ◽  
Author(s):  
Rajesh Kumar ◽  
Jyotirmoy Maity ◽  
Divya Mathur ◽  
Abhishek Verma ◽  
Neha Rana ◽  
...  

Abstract Modified nucleosides are the core precursors for the synthesis of artificial nucleic acids, and are important in the field of synthetic and medicinal chemistry. In order to synthesize various triazolo-compounds, copper and ruthenium catalysed azide–alkyne 1,3-dipolar cycloaddition reactions also known as click reaction have emerged as a facile and efficient tool due to its simplicity and convenient conditions. Introduction of a triazole ring in nucleosides enhances their therapeutic value and various photophysical properties. This review primarily focuses on the plethora of synthetic methodologies being employed to synthesize sugar modified triazolyl nucleosides, their therapeutic importance and various other applications.


2022 ◽  
Vol 0 (0) ◽  
Author(s):  
David Consiglio

Abstract For centuries, farmers have needed fertilizers rich in nitrogen to increase crop yields. This need led to one of the most unusual wars in history: a war over fossilized bird droppings. Twentieth century chemists solved the problem of mass-producing nitrogen fertilizer, but their solution required enormous amounts of energy. Twenty-first century chemists now face the challenge of producing nitrogen fertilizer without the need for energy provided by fossil fuels.


2022 ◽  
Vol 0 (0) ◽  
Author(s):  
Arvind Singh ◽  
Amartya Basu ◽  
Aditi Sharma ◽  
Anu Priya ◽  
Manmmet Kaur ◽  
...  

Abstract 2-Hydroxy-1,4-naphthaquinone, commonly known as lawsone, represents an extremely important biologically active naturally occurring compound. It can easily be isolated from Lawsonia inermis (henna) tree leaf extract. Last decade has seen tremendous applications of lawsone as a starting component for the preparation of various organic scaffolds. Many of these synthesized scaffolds showed a wide range of biological activities including potential activities towards several cancer cell lines. This review deals with diverse synthetic methods of lawsone derived scaffolds and their screening against different anti-cancer cell lines along with promising results.


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