scholarly journals Abca7Null Mice Retain Normal Macrophage Phosphatidylcholine and Cholesterol Efflux Activity despite Alterations in Adipose Mass and Serum Cholesterol Levels

2004 ◽  
Vol 280 (5) ◽  
pp. 3989-3995 ◽  
Author(s):  
Woojin Scott Kim ◽  
Michael L. Fitzgerald ◽  
Kihwa Kang ◽  
Kei-ichiro Okuhira ◽  
Susan A. Bell ◽  
...  
Keyword(s):  
Serum Cholesterol ◽  
Cholesterol Efflux ◽  
Cholesterol Levels ◽  
Adipose Mass ◽  
Normal Macrophage

Effects of Lipid Lowering by Pravastatin on Progression and Regression of Coronary Artery Disease in Symptomatic Men With Normal to Moderately Elevated Serum Cholesterol Levels

Circulation ◽  
1995 ◽  
Vol 91 (10) ◽  
pp. 2528-2540 ◽  
Author(s):  
J. Wouter Jukema ◽  
Albert V.G. Bruschke ◽  
Ad J. van Boven ◽  
Johan H.C. Reiber ◽  
Egbert T. Bal ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Serum Cholesterol ◽  
Elevated Serum ◽  
Lipid Lowering ◽  
Cholesterol Levels ◽  
Artery Disease ◽  
Elevated Serum Cholesterol

scholarly journals High serum cholesterol levels in persons with 'high-normal' TSH levels: should one extend the definition of subclinical hypothyroidism?

1998 ◽  
pp. 141-145 ◽  
Author(s):  
G Michalopoulou ◽  
M Alevizaki ◽  
G Piperingos ◽  
D Mitsibounas ◽  
E Mantzos ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Serum Cholesterol ◽  
Subclinical Hypothyroidism ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Serum ◽  
High Serum Cholesterol ◽  
Cholesterol Levels ◽  
Group D ◽  
Tsh Levels

OBJECTIVE: The association between established hypothyroidism and high cholesterol levels is well known. The aim of the present study was to investigate the effect of thyroxine (T4) administration on cholesterol levels in hypercholesterolemic subjects with TSH levels within the normal range ('high-normal' TSH compared with 'low-normal' TSH). DESIGN AND METHODS: We determined TSH levels in 110 consecutive patients referred for hypercholesterolemia (serum cholesterol >7.5 mmol/l). Those with 'high-normal' TSH (2.0-4.0 microU/ml) as well as those with 'low-normal' TSH (0.40-1.99 microU/ml) were randomly assigned to receive either 25 or 50 microg T4 daily for two months. Thus, groups A and B (low-normal TSH) received 25 and 50 microg T4 respectively and groups C and D (high-normal TSH) received 25 and 50 microg T4 respectively. Serum T4, tri-iodothyronine (T3), TSH, free thyroxine index, resin T3 uptake and thyroid autoantibodies (ThAab) as well as total cholesterol, high and low density lipoprotein cholesterol (HDL, LDL), and triglycerides were determined before and at the end of the two-month treatment period. RESULTS: TSH levels were reduced in all groups. The most striking effect was observed in group D (TSH levels before: 2.77+/-0.55, after: 1.41+/-0.85 microU/ml, P < 0.01). Subjects in groups C and D had a higher probability of having positive ThAabs. A significant reduction in total cholesterol (P < 0.01) and LDL (P < 0.01) was observed after treatment only in group D. In those subjects in group D who were ThAab negative, there was no significant effect of thyroxine on cholesterol levels. CONCLUSIONS: Subjects with high-normal TSH levels combined with ThAabs may, in fact, have subclinical hypothyroidism presenting with elevated cholesterol levels. It is possible that these patients might benefit from thyroxine administration.

scholarly journals A Novel Mutant, ApoA-I Nichinan (Glu235→0), Is Associated With Low HDL Cholesterol Levels and Decreased Cholesterol Efflux From Cells

1999 ◽  
Vol 19 (6) ◽  
pp. 1447-1455 ◽  
Author(s):  
Hua Han ◽  
Jun Sasaki ◽  
Akira Matsunaga ◽  
Hideki Hakamata ◽  
Wei Huang ◽  
...  
Keyword(s):  
Cholesterol Efflux ◽  
Hdl Cholesterol ◽  
Cholesterol Levels ◽  
Low Hdl

Longitudinal associations between serum cholesterol levels and suicidal ideation in an older Korean population

2014 ◽  
Vol 152-154 ◽  
pp. 517-521 ◽  
Author(s):  
Jae-Min Kim ◽  
Robert Stewart ◽  
Hee-Ju Kang ◽  
Bo-ok Jeong ◽  
Seon-Young Kim ◽  
...  
Keyword(s):  
Suicidal Ideation ◽  
Serum Cholesterol ◽  
Korean Population ◽  
Cholesterol Levels ◽  
Longitudinal Associations

Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels

10.1038/4027 ◽  
1998 ◽  
Vol 4 (12) ◽  
pp. 1434-1437 ◽  
Author(s):  
Matti K. Karvonen ◽  
Ullamari Pesonen ◽  
Markku Koulu ◽  
Leo Niskanen ◽  
Markku Laakso ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Serum Cholesterol ◽  
Signal Peptide ◽  
Ldl Cholesterol ◽  
High Serum ◽  
High Serum Cholesterol ◽  
Cholesterol Levels

Estrogen deficiency worsens steatohepatitis in mice fed high-fat and high-cholesterol diet

2011 ◽  
Vol 301 (6) ◽  
pp. G1031-G1043 ◽  
Author(s):  
Yoshihiro Kamada ◽  
Shinichi Kiso ◽  
Yuichi Yoshida ◽  
Norihiro Chatani ◽  
Takashi Kizu ◽  
...  
Keyword(s):  
Risk Factor ◽  
Liver Injury ◽  
Postmenopausal Women ◽  
Serum Cholesterol ◽  
Estrogen Deficiency ◽  
Macrophage Infiltration ◽  
High Cholesterol ◽  
High Fat ◽  
Gene Expressions ◽  
Cholesterol Levels

Recent studies indicate an accelerated progression of nonalcoholic steatohepatitis (NASH) in postmenopausal women. Hypercholesterolemia, an important risk factor for NASH progression, is often observed after menopause. This study examined the effects of estrogen on NASH in ovariectomized (OVX) mice fed a high-fat and high-cholesterol (HFHC) diet. To investigate the effects of estrogen deficiency, OVX mice and sham-operated (SO) mice were fed normal chow or HFHC diet for 6 wk. Next, to investigate the effects of exogenous estrogen replenishment, OVX mice fed with HFHC diet were treated with implanted hormone release pellets (containing 17β-estradiol or placebo vehicle) for 6 wk. OVX mice on the HFHC diet showed enhanced liver injury with increased liver macrophage infiltration and elevated serum cholesterol levels compared with SO-HFHC mice. Hepatocyte monocyte chemoattractant protein-1 (MCP1) protein expression in OVX-HFHC mice was also enhanced compared with SO-HFHC mice. In addition, hepatic inflammatory gene expressions, including monocytes chemokine (C-C motif) receptor 2 (CCR2), were significantly elevated in OVX-HFHC mice. Estrogen treatment improved serum cholesterol levels, liver injury, macrophage infiltration, and inflammatory gene expressions in OVX-HFHC mice. Moreover, the elevated expression of liver CCR2 and MCP1 were decreased by estrogen treatment in OVX-HFHC mice, whereas low-density lipoprotein dose dependently enhanced CCR2 expression in THP1 monocytes. Our study demonstrated that estrogen deficiency accelerated NASH progression in OVX mice fed HFHC diet and that this effect was improved by estrogen therapy. Hypercholesterolemia in postmenopausal women would be a potential risk factor for NASH progression.

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