Effect of chlorpyrifos on some biochemical changes in Cyprinus carpio: the protective effect of ellagic acid

2021 ◽  
pp. 1-6
Author(s):  
Serpil Mişe Yonar ◽  
Muhammet Enis Yonar ◽  
Mevlüt Şener Ural ◽  
Ayşegül Pala
Keyword(s):  
Protective Effect ◽  
Cyprinus Carpio ◽  
Ellagic Acid ◽  
Biochemical Changes

Hematological and biochemical changes in Cyprinus carpio exposed to sub-lethal concentrations of pyriproxyfen

2017 ◽  
Vol 280 ◽  
pp. S176-S177
Author(s):  
Aşkın Barış Kaya ◽  
Derya Kocamaz ◽  
Elif Oruç
Keyword(s):  
Cyprinus Carpio ◽  
Biochemical Changes

scholarly journals Effect of trichlorfon on some haematological and biochemical changes in Cyprinus carpio: The ameliorative effect of lycopene

2020 ◽  
Vol 16 ◽  
pp. 100246 ◽  
Author(s):  
Serpil Mişe Yonar ◽  
M. Enis Yonar ◽  
Ayşegül Pala ◽  
Naim Sağlam ◽  
Fatih Sakin
Keyword(s):  
Cyprinus Carpio ◽  
Biochemical Changes ◽  
Ameliorative Effect

scholarly journals Ellagic Acid Reduces High Glucose-Induced Vascular Oxidative Stress Through ERK1/2/NOX4 Signaling Pathway

2017 ◽  
Vol 44 (3) ◽  
pp. 1174-1187 ◽  
Author(s):  
Artur Rozentsvit ◽  
Kevin Vinokur ◽  
Sherin Samuel ◽  
Ying Li ◽  
A. Martin Gerdes ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Dysfunction ◽  
Protective Effect ◽  
High Glucose ◽  
Ellagic Acid ◽  
Biological Activities ◽  
Radical Scavenging ◽  
Vascular Complications ◽  
Ros Production ◽  
Gene And Protein Expression

Background/Aims: Elevated production of reactive oxygen species (ROS) is linked to endothelial dysfunction and is one of the key contributors to the pathogenesis of diabetic vascular complications. Emerging evidence has indicated that ellagic acid (EA), a polyphenol found in fruits and nuts, possesses numerous biological activities including radical scavenging. However, whether EA exerts a vasculo-protective effect via antioxidant mechanisms in blood vessels exposed to diabetic conditions remains unknown. Accordingly, the goal of this current study was to determine whether EA decreases vascular ROS production and thus ameliorates endothelial dysfunction in the diabetic milieu. Methods: Intact rat aortas and human aortic endothelial cells (HAEC) were stimulated with 30mM high glucose (HG) with and without EA co-treatment. Endothelium-dependent vasodilation was measured using a wire myograph. Gene and protein expression of non-phagocytic nicotinamide adenine dinucleotide phosphate (NADPH) oxidases 4 (NOX4) were detected using RT-PCR and western blotting, respectively. Oxidative stress was determined by measuring ROS levels using dihydroethidium (DHE) staining. Results: Intact aortas exposed to HG condition displayed exacerbated ROS production and impairment of endothelium-dependent vasodilation, characterizing endothelial dysfunction. These effects were markedly reduced with EA treatment. HG enhanced ROS production in HAEC, paralleled by increased ERK1/2 activation and NOX4 expression. EA treatment blunted the increase of ROS generation, ERK1/2 activation and decreased NOX4. Conclusions: EA significantly decreases endothelial ROS levels and ameliorates the impairment of vascular relaxation induced by HG. Our results suggest that EA exerts a vasculo-protective effect under diabetic conditions via an antioxidant effect that involves inhibition of ERK1/2 and downregulation of NOX4.

Protective effect of ellagic acid on healing alveolar bone after tooth extraction in rat—A histological and immunohistochemical study

2014 ◽  
Vol 59 (9) ◽  
pp. 987-999 ◽  
Author(s):  
Mazen M. Jamil Al-Obaidi ◽  
Fouad Hussain Al-Bayaty ◽  
Rami Al Batran ◽  
Pouya Hassandarvish ◽  
Elham Rouhollahi
Keyword(s):  
Protective Effect ◽  
Ellagic Acid ◽  
Tooth Extraction ◽  
Alveolar Bone ◽  
Immunohistochemical Study
Sign in / Sign up

Export Citation Format

Share Document